21 Result(s)

Article

PLMSearch: Protein language model powers accurate and fast sequence search for remote homology

Homologous protein search is one of the most commonly used methods for protein annotation and analysis. Compared to structure search, detecting distant evolutionary relationships from sequences alone remains c...

Wei Liu, Ziye Wang, Ronghui You, Chenghan **e, Hong Wei, Yi **ong… in Nature Communications (2024)

Article

Effective binning of metagenomic contigs using contrastive multi-view representation learning

Contig binning plays a crucial role in metagenomic data analysis by grou** contigs from the same or closely related genomes. However, existing binning methods face challenges in practical applications due to...

Ziye Wang, Ronghui You, Haitao Han, Wei Liu, Fengzhu Sun… in Nature Communications (2024)

Article

Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1

Cytoskeleton is extensively recruited by flaviviruses for their infection. In this study, we uncovered an essential role of a nuclear membrane protein, SAD1/UNC84 domain protein 2 (SUN2) linking cytoskeleton a...

Yanxia Huang, Qinyu Peng, Xu Tian, Cancan Chen, Xuanfeng Zhu… in Nature Communications (2024)

Article

Altered levels of cytokine, T- and B-lymphocytes, and PD-1 expression rates in drug-naïve schizophrenia patients with acute phase

Many studies have investigated the changes of immune cells and proinflammatory cytokines in patients with acute schizophrenia, but few studies have investigated the functional phenotypes of immune cells and th...

Yali Zheng, Qi Zhang, **anqin Zhou, Linjuan Yao, Quanfeng Zhu… in Scientific Reports (2023)

Article

Publisher Correction: Crop switching can enhance environmental sustainability and farmer incomes in China

Wei **e, Anfeng Zhu, Tariq Ali, Zhengtao Zhang, **aoguang Chen, Feng Wu… in Nature (2023)

Article

Prevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naïve patients with major depressive disorder with abnormal glucose metabolism

Comorbid glucose metabolism abnormalities are very common in patients with major depressive disorder (MDD), and glucose metabolism and lipid metabolism are closely related. However, there are few researches on...

Quanfeng Zhu, Guojun Jiang, **aoE Lang, Zhengchuang Fu, Peng Zhang… in Scientific Reports (2023)

Article

Crop switching can enhance environmental sustainability and farmer incomes in China

Achieving food-system sustainability is a multidimensional challenge. In China, a doubling of crop production since 1990 has compromised other dimensions of sustainability^1,2. Although the country is promoting va...

Wei **e, Anfeng Zhu, Tariq Ali, Zhengtao Zhang, **aoguang Chen, Feng Wu… in Nature (2023)

Article

A deep learning-based model for screening and staging pneumoconiosis

This study aims to develop an artificial intelligence (AI)-based model to assist radiologists in pneumoconiosis screening and staging using chest radiographs. The model, based on chest radiographs, was develop...

Liuzhuo Zhang, Ruichen Rong, Qiwei Li, Donghan M. Yang, Bo Yao… in Scientific Reports (2021)

Article

Polymerization mechanism of natural lacquer sap with special phase structure

Lacquer sap is a water-in-oil natural emulsion with high viscosity. In nature, it exudes from the phloem of lacquer tree to repair its wounds in the presence of O₂. So far, it is unclear how rapid and smooth poly...

Jianhong Yang, Nan Chen, Jianfeng Zhu, Jun Cai, Jian** Deng… in Scientific Reports (2020)

Article

Eradication of unresectable liver metastasis through induction of tumour specific energy depletion

Treatment of liver metastasis experiences slow progress owing to the severe side effects. In this study, we demonstrate a strategy capable of eliminating metastatic cancer cells in a selective manner. Nucleus-...

Da Huo, Jianfeng Zhu, Guojun Chen, Qian Chen, Chao Zhang… in Nature Communications (2019)

Article

Chemical shift extremum of ¹²⁹Xe(aq) reveals details of hydrophobic solvation

The ¹²⁹Xe chemical shift in an aqueous solution exhibits a non-monotonic temperature dependence, featuring a maximum at 311 K. This is in contrast to most liquids, where the monotonic decrease of the shift follow...

Petri Peuravaara, Jouni Karjalainen, Jianfeng Zhu, Jiří Mareš… in Scientific Reports (2018)

Article

Manipulating of Different-Polarized Reflected Waves with Graphene-based Plasmonic Metasurfaces in Terahertz Regime

A graphene-based plasmonic metasurface which can independently control different polarized electromagnetic waves with reasonably small losses in terahertz regime is proposed and demonstrated in this paper. Thi...

Li Deng, Yongle Wu, Chen Zhang, Weijun Hong, Biao Peng, Jianfeng Zhu… in Scientific Reports (2017)

Article

Choroidal Thickness in 3001 Chinese Children Aged 6 to 19 Years Using Swept-Source OCT

The purpose of the cross-sectional study is to describe the values and distribution of choroidal thickness and to explore its related factors, especially age, in Chinese children. A total of 3001 Chinese schoo...

Shuyu **ong, **angui He, Junjie Deng, Minzhi Lv, Jiali **, Sifei Sun… in Scientific Reports (2017)

Article

Exogenous melatonin reduces somatic cell count of milk in Holstein cows

High somatic cell counts in milk caused by mastitis significantly influence the quality of milk and result in substantial annual economic loss. This study evaluated the beneficial effects of melatonin (MT) on ...

Minghui Yang, Jianmin Shi, Jianhua Tian, **gli Tao, Menglong Chai… in Scientific Reports (2017)

Article

Melatonin implantation improved the egg-laying rate and quality in hens past their peak egg-laying age

The egg-laying rates of hens approximately 470 days of age exhibited a positive correlation to blood melatonin levels. The hens with an egg-laying rate <30%, 30~90% and ≥90% had blood melatonin levels of 5.8 ±...

Yaxiong Jia, Minghui Yang, Kuanfeng Zhu, Liang Wang, Yukun Song… in Scientific Reports (2016)

Article

The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway

Excessive activation of the TLR4 signalling pathway is critical for inflammation-associated disorders, while negative regulators play key roles in restraining TLR4 from over-activation. Naringenin is a citrus ...

**n Liu, Ning Wang, Shijun Fan, **nchuan Zheng, Yongjun Yang… in Scientific Reports (2016)

Article

Lightweight NiFe₂O₄ with controllable 3D network structure and enhanced microwave absorbing properties

3D network structure NiFe₂O₄ was successfully synthesized by a templated salt precipitation method using PMMA colloid crystal as templates. The morphology, phase composition and microwave absorbing properties of ...

Fen Wang, **ng Wang, Jianfeng Zhu, Haibo Yang, **ngang Kong, **ao Liu in Scientific Reports (2016)

Article

Induction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug–drug interactions

The Aconitum species, which mainly contain bioactive Aconitum alkaloids, are frequently administered concomitantly with other herbal medicines or chemical drugs in clinics. The potential risk of drug–drug interac...

**jun Wu, Na Lin, Fangyuan Li, Guiyu Zhang, Shugui He, Yuanfeng Zhu… in Scientific Reports (2016)

Article

Corneal Epithelium Thickness Profile in 614 Normal Chinese Children Aged 7–15 Years Old

The purpose of the study is to describe the values and distribution of corneal epithelium thickness (CET) in normal Chinese school-aged children, and to explore associated factors with CET. CET maps were measu...

Yingyan Ma, **angui He, **aofeng Zhu, Lina Lu, Jianfeng Zhu… in Scientific Reports (2016)

Article

Nature of charge transport and p-electron ferromagnetism in nitrogen-doped ZrO₂: An ab initio perspective

Zirconium dioxide provides an exceptional prototype material for studying the redistribution of the polaron holes and its magnetic coupling with their nearby anions owning to the difference oxygen binding beha...

Huanfeng Zhu, **g Li, Kun Chen, **nyu Yi, Shuai Cheng, Fuxi Gan in Scientific Reports (2015)