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Open AccessPLMSearch: Protein language model powers accurate and fast sequence search for remote homology
Homologous protein search is one of the most commonly used methods for protein annotation and analysis. Compared to structure search, detecting distant evolutionary relationships from sequences alone remains c...
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Open AccessEffective binning of metagenomic contigs using contrastive multi-view representation learning
Contig binning plays a crucial role in metagenomic data analysis by grou** contigs from the same or closely related genomes. However, existing binning methods face challenges in practical applications due to...
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Open AccessNuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1
Cytoskeleton is extensively recruited by flaviviruses for their infection. In this study, we uncovered an essential role of a nuclear membrane protein, SAD1/UNC84 domain protein 2 (SUN2) linking cytoskeleton a...
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Open AccessAltered levels of cytokine, T- and B-lymphocytes, and PD-1 expression rates in drug-naïve schizophrenia patients with acute phase
Many studies have investigated the changes of immune cells and proinflammatory cytokines in patients with acute schizophrenia, but few studies have investigated the functional phenotypes of immune cells and th...
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Publisher Correction: Crop switching can enhance environmental sustainability and farmer incomes in China
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Open AccessPrevalence and clinical correlates of abnormal lipid metabolism in first-episode and drug-naïve patients with major depressive disorder with abnormal glucose metabolism
Comorbid glucose metabolism abnormalities are very common in patients with major depressive disorder (MDD), and glucose metabolism and lipid metabolism are closely related. However, there are few researches on...
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Crop switching can enhance environmental sustainability and farmer incomes in China
Achieving food-system sustainability is a multidimensional challenge. In China, a doubling of crop production since 1990 has compromised other dimensions of sustainability1,2. Although the country is promoting va...
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Open AccessA deep learning-based model for screening and staging pneumoconiosis
This study aims to develop an artificial intelligence (AI)-based model to assist radiologists in pneumoconiosis screening and staging using chest radiographs. The model, based on chest radiographs, was develop...
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Article
Open AccessPolymerization mechanism of natural lacquer sap with special phase structure
Lacquer sap is a water-in-oil natural emulsion with high viscosity. In nature, it exudes from the phloem of lacquer tree to repair its wounds in the presence of O2. So far, it is unclear how rapid and smooth poly...
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Open AccessEradication of unresectable liver metastasis through induction of tumour specific energy depletion
Treatment of liver metastasis experiences slow progress owing to the severe side effects. In this study, we demonstrate a strategy capable of eliminating metastatic cancer cells in a selective manner. Nucleus-...
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Open AccessChemical shift extremum of 129Xe(aq) reveals details of hydrophobic solvation
The 129Xe chemical shift in an aqueous solution exhibits a non-monotonic temperature dependence, featuring a maximum at 311 K. This is in contrast to most liquids, where the monotonic decrease of the shift follow...
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Open AccessManipulating of Different-Polarized Reflected Waves with Graphene-based Plasmonic Metasurfaces in Terahertz Regime
A graphene-based plasmonic metasurface which can independently control different polarized electromagnetic waves with reasonably small losses in terahertz regime is proposed and demonstrated in this paper. Thi...
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Open AccessChoroidal Thickness in 3001 Chinese Children Aged 6 to 19 Years Using Swept-Source OCT
The purpose of the cross-sectional study is to describe the values and distribution of choroidal thickness and to explore its related factors, especially age, in Chinese children. A total of 3001 Chinese schoo...
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Open AccessExogenous melatonin reduces somatic cell count of milk in Holstein cows
High somatic cell counts in milk caused by mastitis significantly influence the quality of milk and result in substantial annual economic loss. This study evaluated the beneficial effects of melatonin (MT) on ...
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Open AccessMelatonin implantation improved the egg-laying rate and quality in hens past their peak egg-laying age
The egg-laying rates of hens approximately 470 days of age exhibited a positive correlation to blood melatonin levels. The hens with an egg-laying rate <30%, 30~90% and ≥90% had blood melatonin levels of 5.8 ±...
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Open AccessThe citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway
Excessive activation of the TLR4 signalling pathway is critical for inflammation-associated disorders, while negative regulators play key roles in restraining TLR4 from over-activation. Naringenin is a citrus ...
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Open AccessLightweight NiFe2O4 with controllable 3D network structure and enhanced microwave absorbing properties
3D network structure NiFe2O4 was successfully synthesized by a templated salt precipitation method using PMMA colloid crystal as templates. The morphology, phase composition and microwave absorbing properties of ...
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Open AccessInduction of P-glycoprotein expression and activity by Aconitum alkaloids: Implication for clinical drug–drug interactions
The Aconitum species, which mainly contain bioactive Aconitum alkaloids, are frequently administered concomitantly with other herbal medicines or chemical drugs in clinics. The potential risk of drug–drug interac...
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Open AccessCorneal Epithelium Thickness Profile in 614 Normal Chinese Children Aged 7–15 Years Old
The purpose of the study is to describe the values and distribution of corneal epithelium thickness (CET) in normal Chinese school-aged children, and to explore associated factors with CET. CET maps were measu...
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Open AccessNature of charge transport and p-electron ferromagnetism in nitrogen-doped ZrO2: An ab initio perspective
Zirconium dioxide provides an exceptional prototype material for studying the redistribution of the polaron holes and its magnetic coupling with their nearby anions owning to the difference oxygen binding beha...