16 Result(s)
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**anfang Liu
Cell Biology
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Article
Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling
Immune response plays a crucial role in post-myocardial infarction (MI) myocardial remodeling. Neogenin (Neo1), a multifunctional transmembrane receptor, plays a critical role in the immune response; however, ...
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Autologous hematopoietic stem cell transplantation activity for lymphoma and multiple myeloma in China
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Article
The selective contributions of right cerebellar lobules to reading
The engagement of the cerebellum during reading tasks is not unprecedented. However, it is still unclear which regions in the cerebellum are specifically involved in reading and how the cerebellum processes di...
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Open AccessRisk factors affect accurate prognosis in ASXL1-mutated acute myeloid leukemia
The epigenetic regulator additional sex combs-like 1 (ASXL1) is an adverse prognostic factor in acute myeloid leukemia (AML). However, the mutational spectrum and prognostic factors of ASXL1-mutated (ASXL1+) AML ...
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Open AccessAfatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells
Afatinib, a second-generation tyrosine kinase inhibitor (TKI), exerts its antitumor effects in head and neck squamous cell carcinoma (HNSCC) by inducing intrinsic apoptosis through suppression of mTORC1. Howev...
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Reduced listener–speaker neural coupling underlies speech understanding difficulty in older adults
An increasing number of studies have highlighted the importance of listener–speaker neural coupling in successful verbal communication. Whether the brain-to-brain coupling changes with healthy aging and the po...
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miR-4319 inhibited retinoblastoma cells proliferation, migration, invasion and EMT progress via suppressing CD147 mediated MMPs expression
Tumor migration is the critical step that lead to the migration in retinoblastoma (RB), in which microRNAs (miRNAs) play important roles. This study aimed to investigate the role of microRNA-4319 (miR-4319) in...
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Open AccessBranched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells
Ferroptosis, a form of iron-dependent cell death driven by cellular metabolism and iron-dependent lipid peroxidation, has been implicated as a tumor-suppressor function for cancer therapy. Recent advance revea...
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Open AccessLncRNA SNHG11 facilitates tumor metastasis by interacting with and stabilizing HIF-1α
Epigenetic alteration is one of the hallmarks of colorectal cancer (CRC). Many driver genes are regulated by DNA methylation in CRC. However, the role of DNA methylation regulating lncRNAs remain elusive. Here...
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Open AccessDedifferentiation process driven by radiotherapy-induced HMGB1/TLR2/YAP/HIF-1α signaling enhances pancreatic cancer stemness
Differentiated cancer cells reacquiring stem cell traits following radiotherapy may enrich cancer stem cells and accelerate tumor recurrence and metastasis. We are interested in the mechanistic role of dying c...
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Open AccessGenome-wide in vivo screen identifies host molecule in promoting cancer metastasis
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Article
Ginsenoside Rd Improves Learning and Memory Ability in APP Transgenic Mice
Alzheimer’s disease (AD) is a complicated neurodegenerative disease which causes memory loss and dementia. Many researchers have revealed the vital roles of β-amyloid proteins (Aβ) in the proceeds of AD. Aβ de...
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Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells
Epigenetic abnormalities are associated with non-small cell lung cancer (NSCLC) initiation and progression. Epigenetic drugs are being studied and in clinical trials. However, the molecular mechanism underlyin...
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Electrical Stimulation Induces Calcium-Dependent Neurite Outgrowth and Immediate Early Genes Expressions of Dorsal Root Ganglion Neurons
It has been reported that electrical stimulation (ES) can promote nerve regeneration. One of the key factors leading to the promotion is calcium, which plays a vital role in the regulation on electrical activi...
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Open AccessRole of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells
The initiation and progression of various solid tumors, including pancreatic carcinoma, are driven by a population of cells with stem cell properties, namely cancer stem cells (CSCs). Like their normal counter...
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Ginsennoside Rd Attenuates Cognitive Dysfunction in a Rat Model of Alzheimer’s Disease
Alzheimer’s disease is a neurodegenerative disease characterized by the production of β-amyloid proteins and hyperphosphorylation of tau protein. Inflammation and apoptotic severity were highly correlated with...
