33 Result(s)
within
**anfang Liu
Biomedicine
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Article
Open AccessProteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection
Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances, there is considerable variation in clinical outcomes for patients with non...
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Article
Open AccessRefined risk stratification helps guiding transplantation choice in adult BCR::ABL1-positive acute lymphoblastic leukemia
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Open AccessReal-world advantage and challenge of post-autologous stem cell transplantation MRD negativity in high-risk patients with double-hit multiple myeloma
Autologous stem-cell transplantation (ASCT) remains a beneficial approach for patients with newly diagnosed multiple myeloma (NDMM) in the age of novel therapeutic agents. Nevertheless, limited real-world data...
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Article
Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats
Rhubarb anthraquinones contain five main components, that is, rhein, emodin, aloe-emodin, chrysophanol, and physcion, which demonstrate good therapeutic effects on nonalcoholic fatty liver disease (NAFLD). How...
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Article
Phillygenin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis: Suppression of Inflammation and Wnt/β-Catenin Signaling Pathway
Liver fibrosis (LF) is caused by the chronic wound healing response to liver injury from various origins. Among the causes, inflammatory response is the central trigger of LF. Phillygenin (PHI) is a lignan de...
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Article
Kielin/chordin-like protein deficiency causes cardiac aging in male mice
Previous studies have demonstrated that bone morphogenetic proteins (BMPs) play important roles in cardiovascular diseases, including atherosclerosis, artery calcification, myocardial remodeling, pulmonary art...
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Article
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway
Necroptosis is a crucial programmed cell death that is tightly associated with myocardial ischemia/reperfusion injury (MI/RI). Liraglutide is an effective option for the treatment of type 2 diabetes and has re...
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Open AccessDownregulation of SMIM3 inhibits growth of leukemia via PI3K-AKT signaling pathway and correlates with prognosis of adult acute myeloid leukemia with normal karyotype
Acute myeloid leukemia (AML) patients with normal karyotype (NK-AML) have significant variabilities in outcomes. The European Leukemia Net stratification system and some prognostic models have been used to eva...
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Claudin-1/4 as directly target gene of HIF-1α can feedback regulating HIF-1α by PI3K-AKT-mTOR and impact the proliferation of esophageal squamous cell though Rho GTPase and p-JNK pathway
Immunohistochemical microarray comprising 80 patients with esophageal squamous cell carcinoma (ESCC) and discovered that the expression of CLDN1 and CLDN4 were significantly higher in cancer tissues compared to p...
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Article
Open AccessThe emerging landscape of exosomal CircRNAs in solid cancers and hematological malignancies
Circular RNAs (circRNAs) are a type of recently discovered noncoding RNA. They exert their biological functions by competitively binding to microRNAs (miRNAs) as miRNA sponges, promoting gene transcription and...
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Article
The selective contributions of right cerebellar lobules to reading
The engagement of the cerebellum during reading tasks is not unprecedented. However, it is still unclear which regions in the cerebellum are specifically involved in reading and how the cerebellum processes di...
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Article
Open AccessRisk factors affect accurate prognosis in ASXL1-mutated acute myeloid leukemia
The epigenetic regulator additional sex combs-like 1 (ASXL1) is an adverse prognostic factor in acute myeloid leukemia (AML). However, the mutational spectrum and prognostic factors of ASXL1-mutated (ASXL1+) AML ...
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Article
Open AccessApplication of the CRISPR/Cas9-based gene editing technique in basic research, diagnosis, and therapy of cancer
The 2020 Nobel Prize in Chemistry was awarded to Emmanuelle Charpentier and Jennifer Doudna for the development of the Clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease9 (CRI...
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Article
Reduced listener–speaker neural coupling underlies speech understanding difficulty in older adults
An increasing number of studies have highlighted the importance of listener–speaker neural coupling in successful verbal communication. Whether the brain-to-brain coupling changes with healthy aging and the po...
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Open AccessSilencing long non-coding RNA XIST suppresses drug resistance in acute myeloid leukemia through down-regulation of MYC by elevating microRNA-29a expression
Long non-coding RNAs (lncRNAs) are biomarkers participating in multiple disease development including acute myeloid leukemia (AML). Here, we investigated molecular mechanism of X Inactive-Specific Transcript (...
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Publisher Correction: K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8+ T cell activation
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Mutation of a histidine-rich calcium-binding-protein gene in wheat confers resistance to Fusarium head blight
Head or ear blight, mainly caused by Fusarium species, can devastate almost all staple cereal crops (particularly wheat), resulting in great economic loss and imposing health threats on both human beings and live...
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Tumor-educated B cells selectively promote breast cancer lymph node metastasis by HSPA4-targeting IgG
Primary tumors may create the premetastatic niche in secondary organs for subsequent metastasis. Humoral immunity contributes to the progression of certain cancers, but the roles of B cells and their derived a...
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Polysaccharide of Ganoderma and Its Bioactivities
Ganoderma, named lingzhi in China, has been used for centuries as drug and nutraceutical to treat diseases. Based on our research and other literatures, the chapter summarizes the progress of preparation, structu...
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Article
Discovery of novel antagonists on β2-adrenoceptor from natural products using a label-free cell phenotypic assay
Label-free cell phenotypic assays were performed to establish a β2-adrenoceptor (β2-AR) target model in A431 cells and a β1-AR target model in transfected HEK293-β1 cells, using known β2-AR and β1-AR agonists and...
