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Open AccessCholestasis-induced phenotypic transformation of neutrophils contributes to immune escape of colorectal cancer liver metastasis
Cholestasis is a common yet severe complication that occurs during the advancement of liver metastasis. However, how cholestasis impacts the development, treatment, and tumor microenvironment (TME) of liver me...
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Article
Current Treatment Progress of Unilateral Cleft Lip Nasal Deformities
Secondary nasal deformity following unilateral cleft lip is a common facial congenital malformation. Due to its complex treatment, there is currently no unified treatment plan in clinical practice. Dysplasia o...
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High efficiency of boron do** and fast growth realized with a novel gas inlet structure in diamond microwave plasma chemical vapor deposition system
In this work, we have designed a novel gas inlet structure for efficient usage of growth and do** precursors. Our previous gas injection configuration is that the gas is mixed to one pipe first, then divided...
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Article
Open AccessLipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis
Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis, which sequester vulnerable unsaturated triglycerides into LDs to prevent further peroxidation. Here we identify the ...
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Article
High-speed growth of high-quality polycrystalline diamond films by MPCVD
High-quality diamond films have attracted extensive attentions due to their excellent optical and electrical properties. However, several issues, such as random orientation, stress accumulation, and slow growt...
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Open AccessCorrection: Long-term follow-up after discharge witnesses a slow decline of insulin autoantibodies in patients with insulin autoimmune syndrome complicated with grave’s disease: a report of two cases
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Design of a quantum-spin sensor with sub-micron resolution and enhanced optical read-out ability by the nitrogen-vacancy centers in diamond
To solve the inefficiency of optical out-coupling of the nitrogen-vacancy (NV) luminescence in bulk diamond, we propose a quantum-spin sensor based on the NV centers in diamond. The sensor is able to map out t...
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Open AccessThe Description and Prediction of Incidence, Prevalence, Mortality, Disability-Adjusted Life Years Cases, and Corresponding Age-Standardized Rates for Global Diabetes
Diabetes is a life-long disease that poses a serious threat to safety and health. We aimed to assess the disease burden attributable to diabetes globally and by different subgroups, and to predict future disea...
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Open AccessLong-term follow-up after discharge witnesses a slow decline of insulin autoantibodies in patients with insulin autoimmune syndrome complicated with Grave’s disease: a report of two cases
Insulin autoimmune syndrome (IAS) is a rare cause of hypoglycemia characterized by high levels of blood insulin autoantibodies. It has been documented that drugs containing sulfhydryl groups may result in IAS....
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Article
Open AccessAn avalanche-and-surge robust ultrawide-bandgap heterojunction for power electronics
Avalanche and surge robustness involve fundamental carrier dynamics under high electric field and current density. They are also prerequisites of any power device to survive common overvoltage and overcurrent ...
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Article
Trap-mediated bipolar charge transport in NiO/Ga2O3 p+-n heterojunction power diodes
The construction of p-NiO/n-Ga2O3 heterojunction becomes a popular alternative to overcome the technological bottleneck of p-type Ga2O3 for develo** bipolar power devices for practical applications, whereas the...
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Article
Open AccessInkjet Printed Quantum Dots Color Conversion Layers for Full-Color Micro-LED Displays
With the ever-growing demands for larger size and high resolution displays, Micro-light-emitting diode (Micro-LED) display with quantum dots (QDs) film as color conversion layers (CCLs) has become one of the m...
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Open AccessElectroacupuncture improves cognitive impairment in diabetic cognitive dysfunction rats by regulating the mitochondrial autophagy pathway
Diabetes-associated cognitive dysfunction has become a major public health concern. However, the mechanisms driving this disease are elusive. Herein, we explored how electroacupuncture improves learning and me...
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Open AccessA comparative study of interfacial thermal conductance between metal and semiconductor
To understand and control thermal conductance of interface between metal and semiconductor has now become a crucial task for the thermal design and management of nano-electronic and micro-electronic devices. T...
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Surface Bioactive Modification of Alumina Ceramic by Mineralization in Modified SBF
In the present study, it is found that the prepared alumina ceramics has better mineralization ability in a newly revised simulated body fluid. With the extension of mineralization time, the amount of hydroxya...
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In vitro biomineralization behaviors and mechanism as well as cell responses of calcium silicate ceramics
Calcium silicate ceramics have excellent bioactivity and biomineralization performance. In this work, we investigated the effect of different mineralization environments of one time and five times simulated bo...
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Band alignment and polarization engineering in κ-Ga2O3/GaN ferroelectric heterojunction
Ferroelectric-semiconductor heterostructures offer an alternative strategy to manipulate polarization towards advanced devices with engineered functionality and improved performance. In this work, we report on...
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Article
Open AccessDorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma glucose levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activato...
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Open AccessPathological underestimation and biomarkers concordance rates in breast cancer patients diagnosed with ductal carcinoma in situ at preoperative biopsy
Ductal carcinoma in situ (DCIS) often upgrade to invasive breast cancer at surgery. The current study aimed to identify factors associated with pathological underestimation and evaluate concordance rates of bi...
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Synthesis, characterization and cell response of silicon/gallium co-substituted tricalcium phosphate bioceramics
The aim of this study was to fabricate silicon/gallium co-substituted tricalcium phosphate bioceramics having the ability to promote osteoblast activities as well as hinder osteoclast activities. The silicon/g...