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Article
Open AccessAsymmetric total synthesis of polycyclic xanthenes and discovery of a WalK activator active against MRSA
The development of new antibiotics continues to pose challenges, particularly considering the growing threat of multidrug-resistant Staphylococcus aureus. Structurally diverse natural products provide a promising...
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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
PVP/PAN-derived porous carbon fiber for zinc-ion hybrid supercapacitors
Porous carbon fibers are promising cathodes for zinc-ion hybrid supercapacitors (ZHSs) owing to their abundant active sites, great conductivity, and stable physical and chemical properties. However, designing ...
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Article
Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
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Article
Open AccessMeasurement of t-channel production of single top quarks and antiquarks in pp collisions at 13 TeV using the full ATLAS Run 2 data sample
The production of single top quarks and top antiquarks via the t-channel exchange of a virtual W boson is measured in proton-proton collisions at a centre-of-mass energy of 13 TeV at the LHC using 140 fb−1 of ATL...
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Article
Open AccessElectron and photon efficiencies in LHC Run 2 with the ATLAS experiment
Precision measurements of electron reconstruction, identification, and isolation efficiencies and photon identification efficiencies are presented. They use the full Run 2 data sample collected by the ATLAS ex...
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Article
Open AccessSearch for electroweak production of supersymmetric particles in final states with two τ-leptons in \( \sqrt{s} \) = 13 TeV pp collisions with the ATLAS detector
Three searches for the direct production of τ-sleptons or charginos and neutralinos in final states with at least two hadronically decaying τ-leptons are presented. For chargino and neutralino production, decays ...
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Article
Open AccessMeasurement of the total and differential cross-sections of \( t\overline{t}W \) production in pp collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
Measurements of inclusive and differential production cross-sections of a top-quark-top-antiquark pair in association with a W boson ( ...
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Article
Open AccessTest of CP-invariance of the Higgs boson in vector-boson fusion production and in its decay into four leptons
A search for CP violation in the decay kinematics and vector-boson fusion production of the Higgs boson is performed in the H → ZZ* → 4ℓ (ℓ = e, μ) decay channel. The results are based on proton-proton collision ...
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Article
Open AccessPositive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma
Metabolic reprogramming and epigenetic alterations contribute to the aggressiveness of pancreatic ductal adenocarcinoma (PDAC). Lactate-dependent histone modification is a new type of histone mark, which links...
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Article
Molecular hybridization method for obtaining paeonol-based fibrate derivatives with potent lipid-lowering and hepatoprotective activity
Molecular hybridization method was applied to design and synthesize a series of target compounds paeonol-based fibrate derivatives. The target compound was screened using a Triton WR-1339 induced hyperlipidemi...
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Article
Open AccessOn the role of asymmetric molecular geometry in high-performance organic solar cells
Although asymmetric molecular design has been widely demonstrated effective for organic photovoltaics (OPVs), the correlation between asymmetric molecular geometry and their optoelectronic properties is still ...
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Article
Open AccessLoss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing
Protein arginine methyltransferase 9 (PRMT9) is a recently identified member of the PRMT family, yet its biological function remains largely unknown. Here, by characterizing an intellectual disability associat...
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Article
Altered neurovascular coupling in the children with attention-deficit/hyperactivity disorder: a comprehensive fMRI analysis
The coupling between resting-state cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) signals reflects the mechanism of neurovascular coupling (NVC), which have not been illustrated in atte...
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Article
Quality assessment of friction-stir-welded aluminum alloy welds via three-dimensional force signals
An online detection technology must be developed for realizing the real-time control of friction stir welding. In this study, the three-dimensional force exerted on a material during friction stir welding was ...
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Article
Prospective observational study on biomarkers of response in pancreatic ductal adenocarcinoma
Adjuvant chemotherapy benefits patients with resected pancreatic ductal adenocarcinoma (PDAC), but the compromised physical state of post-operative patients can hinder compliance. Biomarkers that identify cand...
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Article
Open AccessSearch for a CP-odd Higgs boson decaying into a heavy CP-even Higgs boson and a Z boson in the \( {\ell}^{+}{\ell}^{-}t\overline{t} \) and \( \nu \overline{\nu}b\overline{b} \) final states using 140 fb−1 of data collected with the ATLAS detector
A search for a heavy CP-odd Higgs boson, A, decaying into a Z boson and a heavy CP-even Higgs boson, H, is presented. It uses the full LHC Run 2 dataset of pp collisions at
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Article
Open AccessSearch for pair production of squarks or gluinos decaying via sleptons or weak bosons in final states with two same-sign or three leptons with the ATLAS detector
A search for pair production of squarks or gluinos decaying via sleptons or weak bosons is reported. The search targets a final state with exactly two leptons with same-sign electric charge or at least three l...
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Article
Open AccessSearch for non-resonant Higgs boson pair production in the \( 2b+2\ell +{E}_{\textrm{T}}^{\textrm{miss}} \) final state in pp collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector
A search for non-resonant Higgs boson pair (HH) production is presented, in which one of the Higgs bosons decays to a b-quark pair ( ...
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Article
Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids
A strong correlation between gut microbes and host health has been observed in numerous gut metagenomic cohort studies. However, the underlying mechanisms governing host–microbe interactions in the gut remain ...
