23 Result(s)
within
**an-hong Tong
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
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Article
Open AccessNeuropeptide natalisin regulates reproductive behaviors in Spodoptera frugiperda
Natalisin (NTL) is a conserved neuropeptide, only present in insects, that has been reported to regulate their sexual activity. In this study, we investigated the involvement of NTL in the reproductive behavio...
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Article
Open AccessGlobal fungal-host interactome map** identifies host targets of candidalysin
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...
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Article
Open AccessMicrobiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts
The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive und...
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Open AccessNext-generation large-scale binary protein interaction network for Drosophila melanogaster
Generating reference maps of interactome networks illuminates genetic studies by providing a protein-centric approach to finding new components of existing pathways, complexes, and processes. We apply state-of...
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Open AccessEstablishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection
Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively modifies proteoglycans (PGs) of ...
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Open AccessA multicentre single arm phase 2 trial of neoadjuvant pyrotinib and letrozole plus dalpiciclib for triple-positive breast cancer
Current therapies for HER2-positive breast cancer have limited efficacy in patients with triple-positive breast cancer (TPBC). We conduct a multi-center single-arm phase 2 trial to test the efficacy and safety...
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Open AccessHigh-resolution silkworm pan-genome provides genetic insights into artificial selection and ecological adaptation
The silkworm Bombyx mori is an important economic insect for producing silk, the “queen of fabrics”. The currently available genomes limit the understanding of its genetic diversity and the discovery of valuable ...
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Open AccessShort term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China
With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...
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Article
Open AccessThe flavonoid corylin exhibits lifespan extension properties in mouse
In the long history of traditional Chinese medicine, single herbs and complex formulas have been suggested to increase lifespan. However, the identification of single molecules responsible for lifespan extensi...
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Open AccessGenomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes
The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...
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Article
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory disease called coronavirus disease 2019 (COVID-19), the spread of which has led to a pandemic. An effective preventive vaccine ...
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Open AccessThe Mouse Gut Microbial Biobank expands the coverage of cultured bacteria
Mice are widely used as experimental models for gut microbiome (GM) studies, yet the majority of mouse GM members remain uncharacterized. Here, we report the construction of a mouse gut microbial biobank (mGMB...
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Article
Open AccessAedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments
Zika virus (ZIKV) is a mosquito-borne flavivirus that predominantly circulates between humans and Aedes mosquitoes. Clinical studies have shown that Zika viruria in patients persists for an extended period, and r...
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Open AccessAuthor Correction: Evolution of the electrochemical interface in sodium ion batteries with ether electrolytes
The original version of this Article incorrectly omitted an affiliation of Kaikai Li: ‘Shenzhen Environmental Science and New Energy Technology Engineering Laboratory, Tsinghua-Berkeley Shenzhen Institute (TBS...
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Open AccessEvolution of the electrochemical interface in sodium ion batteries with ether electrolytes
Ether based electrolytes have surfaced as alternatives to conventional carbonates allowing for enhanced electrochemical performance of sodium-ion batteries; however, the primary source of the improvement remai...
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Article
Open AccessWater use efficiency in a primary subtropical evergreen forest in Southwest China
We calculated water use efficiency (WUE) using measures of gross primary production (GPP) and evapotranspiration (ET) from five years of continuous eddy covariance measurements (2009–2013) obtained over a prim...
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Article
Open AccessCorrection: Corrigendum: Soybean-derived Bowman-Birk Inhibitor (BBI) Inhibits HIV Replication in Macrophages
Scientific Reports 6: Article number: 34752; published online: 13 October 2016; updated: 23 December 2016
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Article
Open AccessSoybean-derived Bowman-Birk Inhibitor (BBI) Inhibits HIV Replication in Macrophages
The Bowman-Birk inhibitor (BBI), a soybean-derived protease inhibitor, is known to have anti-inflammatory effect in both in vitro and in vivo systems. Macrophages play a key role in inflammation and immune activa...
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Open AccessTIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis
Previous study showed that TIGAR (TP53-induced glycolysis and apoptosis regulator) protected ischemic brain injury via enhancing pentose phosphate pathway (PPP) flux and preserving mitochondria function. This ...
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Open AccessNitrogen hurdle of host alternation for a polyphagous aphid and the associated changes of endosymbionts
Low proportion of essential amino acids (EAAs) is one of the barriers for animals to use phloem as a diet. Endosymbionts with EAAs synthesis functions are considered crucial for ameliorating the lack of EAAs i...
