-
Article
Open AccessNeuropeptide natalisin regulates reproductive behaviors in Spodoptera frugiperda
Natalisin (NTL) is a conserved neuropeptide, only present in insects, that has been reported to regulate their sexual activity. In this study, we investigated the involvement of NTL in the reproductive behavio...
-
Article
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and its prevalence is increasing. Currently, no effective therapies for PD exist. Marine-derived natural compounds are considered i...
-
Article
Revolutionizing indoor air quality monitoring through IoT innovations: a comprehensive systematic review and bibliometric analysis
Indoor air quality (IAQ) in the built environment is significantly influenced by particulate matter, volatile organic compounds, and air temperature. Recently, the Internet of Things (IoT) has been integrated ...
-
Article
Application of unmanned aerial vehicle tilt photography technology in geological hazard investigation in China
A major threat is posed to both human society and the environment by geological hazards, necessitating the need for accurate and comprehensive investigation and application in this field. Traditional geologica...
-
Article
Author Correction: CB2 receptor activation inhibits the phagocytic function of microglia through activating ERK/AKT-Nurr1 signal pathways
-
Article
Open AccessCanagliflozin alleviates pulmonary hypertension by activating PPARγ and inhibiting its S225 phosphorylation
Pulmonary hypertension (PH) is a progressive fatal disease with no cure. Canagliflozin (CANA), a novel medication for diabetes, has been found to have remarkable cardiovascular benefits. However, few studies h...
-
Article
Open AccessCorrection: Predictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data
-
Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
-
Article
Time-resolved ultra-small-angle X-ray scattering beamline (BL10U1) at SSRF
The construction of a new beamline, BL10U1, was completed at the Shanghai synchrotron radiation facility in 2020. This multipurpose beamline was designed to provide X-ray scattering techniques such as ultra-sm...
-
Article
Open AccessPredictive models of recurrent implantation failure in patients receiving ART treatment based on clinical features and routine laboratory data
The objective was to construct a model for predicting the probability of recurrent implantation failure (RIF) after assisted reproductive technology (ART) treatment based on the clinical characteristics and ro...
-
Article
Open AccessGlobal fungal-host interactome map** identifies host targets of candidalysin
Candidalysin, a cytolytic peptide toxin secreted by the human fungal pathogen Candida albicans, is critical for fungal pathogenesis. Yet, its intracellular targets have not been extensively mapped. Here, we perfo...
-
Article
Open AccessGut microbiota-derived LCA mediates the protective effect of PEDV infection in piglets
The gut microbiota is a critical factor in the regulation of host health, but the relationship between the differential resistance of hosts to pathogens and the interaction of gut microbes is not yet clear. He...
-
Article
Open AccessGut microbiome for predicting immune checkpoint blockade-associated adverse events
The impact of the gut microbiome on the initiation and intensity of immune-related adverse events (irAEs) prompted by immune checkpoint inhibitors (ICIs) is widely acknowledged. Nevertheless, there is inconsis...
-
Chapter and Conference Paper
Research and Application of Seismic Acquisition in Complex Surface Areas of Southwest Sichuan
The southeast Sichuan Basin is rich in natural gas reserves, with 11 sets of conventional gas and unconventional gas reservoirs. However, the improvement of seismic data quality in this area is restricted by m...
-
Article
Open AccessGenetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis
It remains controversial whether the long-term use of statins or newer nonstatin drugs has a positive effect on human longevity. Therefore, this study aimed to investigate the genetic associations between diff...
-
Article
BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical models
OX40 is a costimulatory receptor that is expressed primarily on activated CD4+, CD8+, and regulatory T cells. The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activ...
-
Article
Huoxin Pill Reduces Myocardial Ischemia Reperfusion Injury in Rats via TLR4/NFκB/NLRP3 Signaling Pathway
To explore the protective effect of Huoxin Pill (HXP) on acute myocardial ischemia-reperfusion (MIRI) injury in rats.
-
Article
Open AccessEMNPD: a comprehensive endophytic microorganism natural products database for prompt the discovery of new bioactive substances
The discovery and utilization of natural products derived from endophytic microorganisms have garnered significant attention in pharmaceutical research. While remarkable progress has been made in this field ea...
-
Article
Open AccessMicrobiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts
The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive und...
-
Article
Synthetic Features and Mechanism for the Preparation of Vinyl Chloride-co-Butyl Acrylate-co-Vinyl Acetate Terpolymer via Precipitation Polymerization
Without any type of surfactant or dispersing agent, precipitation polymerization has great superiorities in both polymer synthesis and applications. In the present work, the polymerization of vinyl chloride (V...
