-
Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
-
Article
Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction
Peri-operative hemorrhagic shock and resuscitation (HSR), a severe traumatic stress, is closely associated with post-operative anxiety, depression, and cognitive dysfunction, subsequently causing a serious bur...
-
Article
Regeneration of photovoltaic industry silicon waste toward high-performance lithium-ion battery anode
The diamond-wire sawing silicon waste (DWSSW) from the photovoltaic industry has been widely considered as a low-cost raw material for lithium-ion battery silicon-based electrode, but the effect mechanism of i...
-
Article
Is ALPPS still appropriate for large or locally advanced hepatocellular carcinoma in an era of targeted agents and immunotherapy?
Therapeutic options for large or locally advanced hepatocellular carcinoma (HCC) have limited efficacy. This study investigated the efficacy and safety of drug-eluting beads trans-arterial chemo-embolization (...
-
Article
Open AccessSpatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...
-
Article
Application of deep learning methods combined with physical background in wide field of view imaging atmospheric Cherenkov telescopes
The High Altitude Detection of Astronomical Radiation (HADAR) experiment, which was constructed in Tibet, China, combines the wide-angle advantages of traditional EAS array detectors with the high-sensitivity ...
-
Article
Open AccessThe effect of white grub (Maladera Verticalis) larvae feeding on rhizosphere microbial characterization of aerobic rice (Oryza sativa L.) in Puer City, Yunnan Province, China
Rhizosphere microorganisms are vital in plants’ growth and development and these beneficial microbes are recruited to the root-zone soil when experiencing various environmental stresses. However, the effect of...
-
Article
A long non-coding RNA functions as a competitive endogenous RNA to modulate TaNAC018 by acting as a decoy for tae-miR6206
Increasing evidence indicates a strong correlation between the deposition of cuticular waxes and drought tolerance. However, the precise regulatory mechanism remains elusive. Here, we conducted a comprehensive...
-
Article
GRIN2A mutation is a novel indicator of stratifying beneficiaries of immune checkpoint inhibitors in multiple cancers
Glutamate-NMDAR receptors (GRINs) have been reported to influence cancer immunogenicity; however, the relationship between GRIN alterations and the response to immune checkpoint inhibitors (ICIs) has not been ...
-
Article
Open AccessEngineering Escherichia coli for high-yielding 2,5-Dimethylpyrazine synthesis from L-Threonine by reconstructing metabolic pathways and enhancing cofactors regeneration
2,5-Dimethylpyrazine (2,5-DMP) is important pharmaceutical raw material and food flavoring agent. Recently, engineering microbes to produce 2,5-DMP has become an attractive alternative to chemical synthesis ap...
-
Article
Mechanism of moxibustion in treating chronic inflammatory visceral pain: regulation of the p38 MAPK/ELK1 signaling pathway in the spinal cord
To investigate the central mechanism of moxibustion in treating chronic inflammatory visceral pain (CIVP) and its analgesic effect from the perspective of the p38 mitogen-activated protein kinase (MAPK)/Ets-li...
-
Article
The identification method for rock strength and joint while drilling based on cutting energy density
Rock strength and joint parameters are the basic parameters reflecting engineering rock quality. The traditional rock strength testing method requires taking cores from the surrounding rock on site and transpo...
-
Article
Highly Improved Creep Resistance in Polypropylene Through Thermally Reduced Graphene Oxide and Its Creep Lifetime Prediction
Polypropylene (PP) exhibits suboptimal creep resistance due to the presence of methyl groups on its main chain, leading to irregular chain segment distribution, diminished inter-chain interaction, and crystall...
-
Article
Creep property and microstructural evolution of DD11 alloy under high temperature and low stress
In this paper, the interrupted and ruptured creep tests were carried out in a novel second generation single crystal superalloy named DD11 at 1100 °C/130 MPa. The alloy exhibited typical creep curve including ...
-
Article
Functional characterization of genes related to triterpene and flavonoid biosynthesis in Cyclocarya paliurus
The oxidosqualene cyclases (OSCs) generating triterpenoid skeletons in Cyclocarya paliurus were identified for the first time, and two uridine diphosphate (UDP)-glycosyltransferases (UGTs) catalyzing the glycosyl...
-
Article
Open AccessAntimicrobial resistance crisis: could artificial intelligence be the solution?
Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be dev...
-
Article
Open AccessDefining the biogeographical map and potential bacterial translocation of microbiome in human ‘surface organs’
The microbiome in a specific human organ has been well-studied, but few reports have investigated the multi-organ microbiome as a whole. Here, we aim to analyse the intra-individual inter-organ and intra-organ...
-
Chapter and Conference Paper
Analyzing Influence of Epidemic Policy Adjustment on Public Concerns and Emotional Feedback Using the ABSA Approach
Based on the aspect-based sentiment analysis (ABSA), this paper proposed a topic clustering extension method that integrated LDA topic information and BERT context information, constructed the topics and their...
-
Chapter and Conference Paper
Cementing Practice of Easy-Leaking Formations Under Complex Geological Conditions
Jizhong buried-hill reservoir and Menggulin conglomerate heavy oil reservoir in Huabei Oilfield contain abundant residual oil and gas resources. In order to use the reserves as much as possible, CO2 injection gra...
-
Article
NνDEx-100 conceptual design report
Observing nuclear neutrinoless double beta (0 \(\nu \beta \beta\) ν ...
