446 Result(s)
within
**an-feng Li
Life Sciences
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Article
Open AccessProbiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model
Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake and milk production, which can lead to higher mortality rates in newborn piglets. The probiotic Lactobacillus...
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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
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Adaptation of a prey population to increasing predation risks
To test the hypotheses that multigenerational predation risk favors clones with longer postero-lateral spines and a larger body, and that fitness consequences of selection depend on both tested fitness variabl...
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Open AccessNicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis
Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain unce...
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Coordinated action of a gut–liver pathway drives alcohol detoxification and consumption
Alcohol use disorder (AUD) affects millions of people worldwide, causing extensive morbidity and mortality with limited pharmacological treatments. The liver is considered as the principal site for the detoxif...
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Open AccessAMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
The shift of carbon utilization from primarily glucose to other nutrients is a fundamental metabolic adaptation to cope with decreased blood glucose levels and the consequent decline in glucose oxidation. AMP-...
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Open AccessA dual-function selection system enables positive selection of multigene CRISPR mutants and negative selection of Cas9-free progeny in Arabidopsis
The CRISPR/Cas9 technology revolutionizes targeted gene knockout in diverse organisms including plants. However, screening edited alleles, particularly those with multiplex editing, from herbicide- or antibiot...
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Identifying modifiable factors and their joint effect on brain health: an exposome-wide association study
Considerable uncertainty remains regarding the associations of multiple factors with brain health. We aimed to conduct an exposome-wide association study on neurodegenerative disease and neuropsychiatry disord...
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Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
While numerous genomic loci have been identified for neuropsychiatric conditions, the contribution of protein-coding variants has yet to be determined. Here we conducted a large-scale whole-exome-sequencing st...
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Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism
Age-related changes in testicular function can impact health and well-being. The mechanisms underlying age-related testicular dysfunction, such as late-onset hypogonadism (LOH), remain incompletely understood....
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Metagenomic analysis of individual mosquito viromes reveals the geographical patterns and drivers of viral diversity
Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a ...
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Characterization of Bacillus amyloliquefaciens PM415 as a potential bio-preserving probiotic
Animal feed is vulnerable to fungal infections, and the use of bio-preserving probiotics has received increasing attention. In contrast to Lactobacillus and Bifidobacteria spp., fewer Bacillus spp. have been reco...
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High dimensional proteomic map** of bone marrow immune characteristics in immune thrombocytopenia
To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia (ITP), this study mapped the immune cell heterogeneity in the bone marrow of ITP at the sing...
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Open AccessGenomic evidence for human-mediated introgressive hybridization and selection in the developed breed
The pig (Sus Scrofa) is one of the oldest domesticated livestock species that has undergone extensive improvement through modern breeding. European breeds have advantages in lean meat development and highly-produ...
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Socioeconomic status, lifestyle and risk of incident dementia: a prospective cohort study of 276730 participants
Healthy lifestyle might alleviate the socioeconomic inequities in health, but the extent of the joint and interactive effects of these two factors on dementia are unclear. This study aimed to detect the joint ...
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Open AccessReductive soil disinfestation by mixing carbon nanotubes and mushroom residues to mitigate the continuous crop** obstacles for Lilium Brownii
Reductive soil disinfestation can effectively alleviate continuous crop** obstacles. The effects of mixing mushroom residues and carbon nanotubes on the structure and function of soil microbial communities a...
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Open AccessCurriculum vitae of CUG binding protein 1 (CELF1) in homeostasis and diseases: a systematic review
RNA-binding proteins (RBPs) are kinds of proteins with either singular or multiple RNA-binding domains (RBDs), and they can assembly into ribonucleic acid–protein complexes, which mediate transportation, editi...
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Open AccessRGA1 regulates grain size, rice quality and seed germination in the small and round grain mutant srg5
Generating elite rice varieties with high yield and superior quality is the main goal of rice breeding programs. Key agronomic traits, including grain size and seed germination characteristics, affect the fina...
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Solibacillus ferritrahens sp. nov., a novel siderophore-producing bacterium isolated from Wumeng Mountain National Nature Reserve in Yunnan Province
A gram-stain-positive, aerobic, rod-shaped bacterial strain capable of producing siderophores, named YIM B08730T, was isolated from a soil sample collected from Wumeng Mountain National Nature Reserve, Zhaotong C...
