337 Result(s)
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Article
Open AccessAsymmetric total synthesis of polycyclic xanthenes and discovery of a WalK activator active against MRSA
The development of new antibiotics continues to pose challenges, particularly considering the growing threat of multidrug-resistant Staphylococcus aureus. Structurally diverse natural products provide a promising...
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Open AccessGlutamate acts on acid-sensing ion channels to worsen ischaemic brain injury
Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-d-aspartate receptor)-dependent cell death pathways in stroke1,2, but unsuccessful clinical trials with NMDAR antagonists impli...
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Open AccessLeukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis
Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells in the bone marrow. MM patients with aggressive progression have poor survival, emphasizing the urg...
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Open AccessImpact of chronic kidney disease and end-stage renal disease on the mid-term adverse outcomes in diabetic patients with cardiovascular diseases
The evidence for the impact of renal dysfunction in patients with diabetes mellitus (DM) and first cardiovascular diseases on mid-term adverse outcomes remain scarce. This study included the data of patients w...
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Open AccessNOTCH3 as a prognostic biomarker and its correlation with immune infiltration in gastrointestinal cancers
NOTCH receptor 3 (NOTCH3) is known to regulate the transcription of oncogenes or tumor suppressor genes, thereby playing a crucial role in tumor development, invasion, maintenance, and chemotherapy resistance....
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Open AccessThe impact of ZTE-based MR attenuation correction compared to CT-AC in 18F-FBPA PET before boron neutron capture therapy
Tumor-to-normal ratio (T/N) measurement of 18F-FBPA is crucial for patient eligibility to receive boron neutron capture therapy. This study aims to compare the difference in standard uptake value ratios on brain ...
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Open AccessThe role of CO2 in the genesis of Dabie-type porphyry molybdenum deposits
Porphyry-type molybdenum deposits, many of which are in China, supply most of the World’s molybdenum. Of particular importance are the molybdenum deposits located in the Qinling-Dabie region that are responsib...
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Open AccessA whole-slide foundation model for digital pathology from real-world data
Digital pathology poses unique computational challenges, as a standard gigapixel slide may comprise tens of thousands of image tiles1–3. Prior models have often resorted to subsampling a small portion of tiles fo...
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Open AccessRobotic versus laparoscopic distal gastrectomy for resectable gastric cancer: a randomized phase 2 trial
Robotic surgery may be an alternative to laparoscopic surgery for gastric cancer (GC). However, randomized controlled trials (RCTs) reporting the differences in survival between these two approaches are curren...
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Open AccessA bi-directional segmentation method for prostate ultrasound images under semantic constraints
Due to the lack of sufficient labeled data for the prostate and the extensive and complex semantic information in ultrasound images, accurately and quickly segmenting the prostate in transrectal ultrasound (TR...
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Open AccessZero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy
Computational super-resolution methods, including conventional analytical algorithms and deep learning models, have substantially improved optical microscopy. Among them, supervised deep neural networks have d...
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Open AccessMechanism and deterioration pattern of sandstone surrounding rock voiding at bottom of heavy-haul railway tunnel
This study combines laboratory experiments and discrete element simulation methods to analyze the mechanism and deterioration patterns of sandstone surrounding rock voiding the bottom of a heavy-haul railway t...
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Open AccessIdentification and validation of N-acetylputrescine in combination with non-canonical clinical features as a Parkinson’s disease biomarker panel
Parkinson’s disease is a progressive neurodegenerative disorder in which loss of dopaminergic neurons in the substantia nigra results in a clinically heterogeneous group with variable motor and non-motor sympt...
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Open AccessLarge-language models facilitate discovery of the molecular signatures regulating sleep and activity
Sleep, locomotor and social activities are essential animal behaviors, but their reciprocal relationships and underlying mechanisms remain poorly understood. Here, we elicit information from a cutting-edge lar...
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Creation of memory–memory entanglement in a metropolitan quantum network
Towards realizing the future quantum internet1,2, a pivotal milestone entails the transition from two-node proof-of-principle experiments conducted in laboratories to comprehensive multi-node set-ups on large sca...
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Open AccessFine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...
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Open AccessStress-induced ordering evolution of 1D segmented heteronanostructures and their chemical post-transformations
Investigations of one-dimensional segmented heteronanostructures (1D-SHs) have recently attracted much attention due to their potentials for applications resulting from their structure and synergistic effects ...
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Open AccessAn improved technology for monitoring groundwater flow velocity and direction in fractured rock system based on colloidal particles motion
The colloidal borescope, using colloidal particle motion, is used to monitor the flow velocities and directions of groundwater. It integrates advanced techniques such as microscopy, high-speed photography, and...
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Open AccessMitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype
Bacterial genotoxins damage host cells by targeting their chromosomal DNA. In the present study, we demonstrate that a genotoxin of Salmonella Typhi, typhoid toxin, triggers the senescence-associated secretory ph...
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Open AccessWhite and gray matter integrity evaluated by MRI-DTI can serve as noninvasive and reliable indicators of structural and functional alterations in chronic neurotrauma
We aimed to evaluate whether white and gray matter microstructure changes observed with magnetic resonance imaging (MRI)-based diffusion tensor imaging (DTI) can be used to reflect the progression of chronic b...
