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Article
Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells
Cuproptosis is characterized by the aggregation of lipoylated enzymes of the tricarboxylic acid cycle and subsequent loss of iron-sulfur cluster proteins as a unique copper-dependent form of regulated cell dea...
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Article
A data-driven approach for predicting the fatigue life and failure mode of self-piercing rivet joints
In lightweight automotive vehicles, the application of self-piercing rivet (SPR) joints is becoming increasingly widespread. Considering the importance of automotive service performance, the fatigue performanc...
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Article
Correction: Nomogram based on pretreatment hepatic and renal function indicators for survival prediction of locally advanced esophageal squamous cell carcinoma with treatment of neoadjuvant chemoradiotherapy plus surgery
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Article
Open AccessReal-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes
Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. I...
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Article
Effects of Humic Acid-Copper Interactions on Growth, Nutrient Absorption, and Photosynthetic Performance of Citrus sinensis Seedlings in Sand Culture
In China, high copper (Cu) and low organic matter often occur in some citrus orchard soils. However, the underlying mechanisms by which humic acid (HA) stimulates growth and mitigates Cu toxicity of citrus see...
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Article
Open AccessIdentification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations
Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mut...
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Article
Light-induced stepped thermal relaxation in a Hofmann-type metal-organic framework
Spin-crossover (SCO) materials with light-induced multistability have potential applications in multi-addressable opto-magnetic memory devices and multiple switches. Here, we reported a three-dimensional Hofma...
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Article
Mitogen-Activated Protein Kinases Mediate Adventitial Fibroblast Activation and Neointima Formation via GATA4/Cyclin D1 Axis
Activation of mitogen-activated protein kinases (MAPKs) by pathological stimuli participates in cardiovascular diseases. Dysfunction of adventitial fibroblast has emerged as a critical regulator in vascular re...
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Article
Open AccessEvaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
Human liver-derived metabolically competent HepaRG cells have been successfully employed in both two-dimensional (2D) and 3D spheroid formats for performing the comet assay and micronucleus (MN) assay. In the ...
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Article
Open AccessMulti-risk factors joint prediction model for risk prediction of retinopathy of prematurity
Retinopathy of prematurity (ROP) is a retinal vascular proliferative disease common in low birth weight and premature infants and is one of the main causes of blindness in children.
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Article
Achieving high carrier mobility and low lattice thermal conductivity in GeTe-based alloys by cationic/anionic co-do**
The IV–VI compound GeTe is considered as a promising alternative to the toxic PbTe for high-efficiency mid-temperature thermoelectric applications. However, pristine GeTe suffers from a high concentration of G...
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Article
Open AccessABO and Rhesus blood groups and multiple health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies
Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associa...
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Article
Open AccessOctyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor,...
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Article
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer
The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for the treatment of prostate cancer. Herein, we report the identification, optimization, and evaluat...
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Article
Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii
Carbapenem-resistant Acinetobacter baumannii infections have limited treatment options. Synthesis, transport and placement of lipopolysaccharide or lipooligosaccharide (LOS) in the outer membrane of Gram-negative...
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Article
Open AccessA survey of model compression strategies for object detection
Deep neural networks (DNNs) have achieved great success in many object detection tasks. However, such DNNS-based large object detection models are generally computationally expensive and memory intensive. It i...
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Article
Substrate-free ultra-thin epidermal bioelectrodes with enhanced conformality and breathability for long-term physiological monitoring
The development of durable and reliable bioelectrodes for high-quality bioelectrical signals acquisition has become a crucial technology in the field of human physiological condition monitoring and human-machi...
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Article
Open AccessRetinoic acid mitigates the NSC319726-induced spermatogenesis dysfunction through cuproptosis-independent mechanisms
Copper ionophore NSC319726 has attracted researchers' attention in treating diseases, particularly cancers. However, its potential effects on male reproduction during medication are unclear. This study aimed t...
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Article
Open AccessCurrent challenges and therapeutic advances of CAR-T cell therapy for solid tumors
The application of chimeric antigen receptor (CAR) T cells in the management of hematological malignancies has emerged as a noteworthy therapeutic breakthrough. Nevertheless, the utilization and effectiveness...
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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
