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Article
MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer’s Disease
Alzheimer’s disease (AD) represents the most widespread neurodegenerative disorder, distinguished by a gradual onset and slow progression, presenting a substantial challenge to global public health. The mitoch...
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Article
A novel dual-signal output strategy for POCT of CEA based on a smartphone electrochemical aptasensing platform
A smartphone-based electrochemical aptasensing platform was developed for the point-of-care testing (POCT) of carcinoembryonic antigen (CEA) based on the ferrocene (Fc) and PdPt@PCN-224 dual-signal labeled st...
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Article
Existence and Stability of Fuzzy Slightly Altruistic Equilibrium for a Class of Generalized Multiobjective Fuzzy Games
We mainly study the existence, structural stability and robustness of fuzzy slightly altruistic equilibria for a class of generalized multiobjective fuzzy games which are expressed as
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Article
Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview
Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic ...
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Article
Open AccessClinical significance and prospective mechanism of increased CDKN2A expression in small cell lung cancer
Although it has been shown that cyclin dependent kinase inhibitor 2A (CDKN2A) plays a significant role in a number of malignancies, its clinicopathological value and function in small cell lung cancer (SCLC) i...
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Article
Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
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Article
Bio-mediated geotechnology and its application in geoengineering: mechanism, approach, and performance
Bio-mediated geotechnology refers to the technology that utilizes various types of microbial processes to improve the hydro-mechanical behavior of soil and rock, aiming for the prevention and mitigation of geo...
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Article
Open AccessBiosynthetic production of anticoagulant heparin polysaccharides through metabolic and sulfotransferases engineering strategies
Heparin is an important anticoagulant drug, and microbial heparin biosynthesis is a potential alternative to animal-derived heparin production. However, effectively using heparin synthesis enzymes faces challe...
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Article
Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis
Colorectal cancer (CRC) is a prevalent form of gastrointestinal malignancy with challenges in chemotherapy resistance and side effects. Effective and low toxic drugs for CRC treatment are urgently needed. Ferr...
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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
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Article
Open AccessHidden diversity and potential ecological function of phosphorus acquisition genes in widespread terrestrial bacteriophages
Phosphorus (P) limitation of ecosystem processes is widespread in terrestrial habitats. While a few auxiliary metabolic genes (AMGs) in bacteriophages from aquatic habitats are reported to have the potential t...
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Article
Open AccessAn improved technology for monitoring groundwater flow velocity and direction in fractured rock system based on colloidal particles motion
The colloidal borescope, using colloidal particle motion, is used to monitor the flow velocities and directions of groundwater. It integrates advanced techniques such as microscopy, high-speed photography, and...
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Article
The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders
Despite its crucial role in the regulation of vital metabolic and neurological functions, the genetic architecture of the hypothalamus remains unknown. Here we conducted multivariate genome-wide association st...
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Open AccessIdentification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic regulators of cardiac development, pro...
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Article
Open AccessAssembly and characterization of the complete mitochondrial genome of Descurainia sophia: a medical plant producing glucosinolate
As a commonly used traditional Chinese medicine, Descurainia sophia has various reported pharmacological activities such as prevention of chronic diseases, cardiovascular protection, neuroprotection, anticancer, ...
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Article
Open AccessADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition
Hyalectan cleavage may play an important role in extracellular matrix remodeling. However, the proteolytic enzyme responsible for hyalectan degradation for fetal membrane rupture at parturition remains unknown...
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Article
Design of an active-source seismic detection system based on illumination analysis and migration imaging experiments: considering the Zhuxi mining area as an example
The purpose of this paper is to discuss the feasibility of utilizing the non-explosive source green seismic exploration technology to detect mineral resources in the deep of complex mountainous areas of wester...
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Article
Entomopathogenic fungal-derived metabolites alter innate immunity and gut microbiota in the migratory locust
There are complex temporal and spatial interactions between insects and microbes. Previously, the function of microbial virulence factors has been identified and characterized. However, the roles of disease-re...
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Article
Open AccessThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia
In recent years, the development of adjunctive therapeutic hyperthermia for cancer therapy has received considerable attention. However, the mechanisms underlying hyperthermia resistance are still poorly under...
