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Article
Open AccessSearch for central exclusive production of top quark pairs in proton-proton collisions at \( \sqrt{s} \) = 13 TeV with tagged protons
A search for the central exclusive production of top quark-antiquark pairs ( t t ...
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Article
Open AccessGastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) a...
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Article
Open AccessDEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis
The alveolar epithelial type II cell (AT2) and its senescence play a pivotal role in alveolar damage and pulmonary fibrosis. Cell circadian rhythm is strongly associated with cell senescence. Differentiated em...
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Article
Enhanced transport of K-nZVI by bentonite suspensions in porous media
Due to high reactivity and relatively low cost, nano zero-valent iron (nZVI) has become an alternative material for in-situ remediation of contaminated sites. However, factors such as short transport distance ...
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Article
Open AccessOptimization of seeding density of OP9 cells to improve hematopoietic differentiation efficiency
OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hematopoietic stem/progenitor cells (HSPCs). However, the whole co-culture procedure usuall...
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Article
Open AccessBlood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer’s disease diagnosis and differential diagnosis
Accurate differential diagnosis among various dementias is crucial for effective treatment of Alzheimer’s disease (AD). The study began with searching for novel blood-based neuronal extracellular vesicles (EVs...
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Article
A discharging internal resistance dynamic model of lithium-ion batteries based on multiple influencing factors
Direct current internal resistance (DCR) is a key indicator for assessing the health status of batteries, and it is of significant importance in practical applications for power estimation and battery thermal ...
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Article
The identification method for rock strength and joint while drilling based on cutting energy density
Rock strength and joint parameters are the basic parameters reflecting engineering rock quality. The traditional rock strength testing method requires taking cores from the surrounding rock on site and transpo...
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Article
Clarity on the blazing trail: clearing the way for amyloid-removing therapies for Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with a complex pathogenesis. Senile plaques composed of the amyloid-β (Aβ) peptide in the brain are the core hallmarks of AD and a promising...
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Article
Morphological and phylogenetic analyses reveal a new species of Anthracophyllum (Omphalotaceae, Agaricales) in Zhejiang Province, China
During the investigations of macrofungi resources in Zhejiang Province, China, an interesting wood rot fungus was collected. Based on morphological and molecular phylogenetic studies, it is described as a new ...
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Article
Fundamentals and catalytic applications of single-atom alloys
Single-atom alloys that consist of a catalytically active metal atomically dispersed in a less-catalytic metal host have recently attracted significant concern from worldwide researchers. The unique geometric ...
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Article
Open AccessComprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities
Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...
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Article
CFD analysis of a CiADS fuel assembly during the steam generator tube rupture accident based on the LBEsteamEulerFoam
Steam generator tube rupture (SGTR) accident is an important scenario needed to be considered in the safety analysis of lead-based fast reactors. When the steam generator tube breaks close to the main pump, wa...
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Article
Open AccessMeasurement of the top quark mass using a profile likelihood approach with the lepton + jets final states in proton–proton collisions at \(\sqrt{s}=13\,\text {Te}\hspace{-.08em}\text {V} \)
The mass of the top quark is measured in 36.3 \(\,\text {fb}^{-1}\) ...
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Article
The Aging Biomarker Consortium represents a new era for aging research in China
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Open AccessMesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges
Skin wounds are characterized by injury to the skin due to trauma, tearing, cuts, or contusions. As such injuries are common to all human groups, they may at times represent a serious socioeconomic burden. Cur...
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Article
Open AccessSearch for high-mass exclusive γγ → WW and γγ → ZZ production in proton-proton collisions at \( \sqrt{s} \) = 13 TeV
A search is performed for exclusive high-mass γγ → WW and γγ → ZZ production in proton-proton collisions using intact forward protons reconstructed in near-beam detectors, with both weak bosons decaying into boos...
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Article
ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer
Cisplatin (CDDP)-based chemotherapy is a first-line, drug regimen for muscle-invasive bladder cancer (BC) and metastatic bladder cancer. Clinically, resistance to CDDP restricts the clinical benefit of some bl...
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Article
Biomarkers of aging
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...
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Article
Open AccessSubty**-based platform guides precision medicine for heavily pretreated metastatic triple-negative breast cancer: The FUTURE phase II umbrella clinical trial
Triple-negative breast cancer (TNBC) is a heterogeneous disease and lacks effective treatment. Our previous study classified TNBCs into four subtypes with putative therapeutic targets. Here, we report the fina...
