44 Result(s)
within
**an-Hui Zhong
Life Sciences
English
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Article
Open AccessIncreased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...
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Open AccessThe m6A reader HNRNPC promotes glioma progression by enhancing the stability of IRAK1 mRNA through the MAPK pathway
Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells and plays an important role in the occurrence and dev...
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Repair of dysfunctional bone marrow endothelial cells alleviates aplastic anemia
Aplastic anemia (AA) is a life-threatening disease characterized by bone marrow (BM) failure and pancytopenia. As an important component of the BM microenvironment, endothelial cells (ECs) play a crucial role ...
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AIWW: a new nutrition-screening tool for the oncologic population
Malnutrition is a common comorbidity among patients with cancer. However, no nutrition-screening tool has been recognized in this population. A quick and easy screening tool for nutrition with high sensitivity...
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Seasonal flexibility of the gut structure and physiology in Eremias multiocellata
Although gut seasonal plasticity has been extensively reported, studies on physiological flexibility, such as water-salt transportation and motility in reptiles, are limited. Therefore, this study investigated...
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Countering beta-cypermethrin: partitioning roles of the insect gut and its bacteria
Insects and their gut bacteria can degrade insecticides separately, which is helpful for insecticide resistance development. However, there is little knowledge about insect and gut bacteria cooperation or thei...
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In situ electrochemical Raman spectroscopy and ab initio molecular dynamics study of interfacial water on a single-crystal surface
The dynamics and chemistry of interfacial water are essential components of electrocatalysis because the decomposition and formation of water molecules could dictate the protonation and deprotonation processes...
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Open AccessDifferential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques
SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries, however, the underlying mechanism, in particular immune responses in different organs, remains elusive. In th...
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Open AccessCytochemical and comparative transcriptome analyses elucidate the formation and ecological adaptation of three types of pollen coat in Zingiberaceae
The pollen ornate surface of flowering plants has long fascinated and puzzled evolutionary biologists for their variety. Each pollen grain is contained within a pollen wall consisting of intine and exine, over...
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Open AccessTCA cycle enhancement and uptake of monomeric substrates support growth of marine Roseobacter at low temperature
Members of the marine Roseobacter group are ubiquitous in global oceans, but their cold-adaptive strategies have barely been studied. Here, as represented by Loktanella salsilacus strains enriched in polar region...
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Open AccessSubsequent malaria enhances virus-specific T cell immunity in SIV-infected Chinese rhesus macaques
Coinfection with HIV and Plasmodium parasites is fairly common, but the sequence of infection with these two pathogens and their impact on disease progression are poorly understood.
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Alteromonas oceanisediminis sp. nov., isolated from deep-sea sediment
A Gram-stain-negative, aerobic and rod-shaped bacterium, designated strain SM 2104T, was isolated from a deep-sea sediment sample collected from the Southwest Indian Ocean. Strain SM 2104T grew at 10–37 °C (optim...
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Open AccessLipid nanoparticle-encapsulated mRNA antibody provides long-term protection against SARS-CoV-2 in mice and hamsters
Monoclonal antibodies represent important weapons in our arsenal to against the COVID-19 pandemic. However, this potential is severely limited by the time-consuming process of develo** effective antibodies a...
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Transcriptomic analyses reveal the effect of nitric oxide on the lateral root development and growth of mangrove plant Kandelia obovata
Kandelia obovata, a dominant mangrove species in China, produces complex buttress roots and prop roots in intertidal wetlands where high quantities of nitric oxide (NO) are produced by reducing sediments. NO, a ...
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GP73 is a glucogenic hormone contributing to SARS-CoV-2-induced hyperglycemia
Severe cases of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with elevated blood glucose levels and metabolic complications. However, the molecular mechanisms for ...
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Open AccessMesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways
Mesenchymal stem cell (MSC) therapy has become a promising treatment for liver fibrosis due to its predominant immunomodulatory performance in hepatic stellate cell inhibition and fibrosis resolution. However,...
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Open AccessHistone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1
TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still r...
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Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions
Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain tumor microenvironment in a reproducible and scalable system, we developed a rapid three-dimensional (3D) bioprinting me...
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Characterization of Pneumocystis jirovecii pneumonia at three tertiary comprehensive hospitals in southern China
Due to the increasing use of immunosuppressant therapy, Pneumocystis jirovecii pneumonia (PJP) has become an emerging concern in human immunodeficiency virus (HIV)-negative patients. In this study, we conducted a...
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Open AccessOne-step generation of composite soybean plants with transgenic roots by Agrobacterium rhizogenes-mediated transformation
Agrobacterium rhizogenes-mediated (ARM) transformation is a highly efficient technique for generating composite plants composed of transgenic roots and wild-type shoot, providing a powerful tool for studying root...
