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Article
Open AccessTargeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium. This phenomenon is known as myocardi...
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Article
Open AccessDeciphering the Belle II data on \( B\to K\nu \overline{\nu} \) decay in the (dark) SMEFT with minimal flavour violation
Recently, the Belle II collaboration announced the first measurement of the branching ratio B ...
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Article
Open AccessThe single-cell opioid responses in the context of HIV (SCORCH) consortium
Substance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of th...
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Article
Open AccessDe novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation
The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovar...
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Article
Open AccessStructural variant landscapes reveal convergent signatures of evolution in sheep and goats
Sheep and goats have undergone domestication and improvement to produce similar phenotypes, which have been greatly impacted by structural variants (SVs). Here, we report a high-quality chromosome-level refere...
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Article
Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity
The CRISPR system is an adaptive immune system found in prokaryotes that defends host cells against the invasion of foreign DNA1. As part of the ongoing struggle between phages and the bacterial immune system, th...
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Article
Stigma of mental illness among health professions and non-health professions students in China
It is still unclear about the differences of stigma of mental illness and its influencing factors between health profession (HP) and non-health profession (NHP) students in China. This study aimed to explore t...
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Article
Open AccessZero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy
Computational super-resolution methods, including conventional analytical algorithms and deep learning models, have substantially improved optical microscopy. Among them, supervised deep neural networks have d...
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Article
Open AccessSearch for electroweak production of supersymmetric particles in final states with two τ-leptons in \( \sqrt{s} \) = 13 TeV pp collisions with the ATLAS detector
Three searches for the direct production of τ-sleptons or charginos and neutralinos in final states with at least two hadronically decaying τ-leptons are presented. For chargino and neutralino production, decays ...
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Article
Open AccessATLAS Run 2 searches for electroweak production of supersymmetric particles interpreted within the pMSSM
A summary of the constraints from searches performed by the ATLAS collaboration for the electroweak production of charginos and neutralinos is presented. Results from eight separate ATLAS searches are consider...
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Article
Open AccessTumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling
Whether stem-cell-like cancer cells avert ferroptosis to mediate therapy resistance remains unclear. In this study, using a soft fibrin gel culture system, we found that tumor-repopulating cells (TRCs) with st...
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Article
Open AccessDisruption of maternal vascular remodeling by a fetal endoretrovirus-derived gene in preeclampsia
Preeclampsia, one of the most lethal pregnancy-related diseases, is associated with the disruption of uterine spiral artery remodeling during placentation. However, the early molecular events leading to preecl...
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Article
A backfill material without cementitious material: Carbonation curing magnesium slag based full solid waste backfill material
In view of the two major problems of the rapid growth of global CO2 emissions and the high cost of mine backfill materials (cement). In this study, a new method of mixing coal gangue (CG), magnesium slag (MS) and...
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Article
Mechanism of a dual-phase Ti-Nb alloy exhibiting near-linear elastic deformation
In this work, the underlying mechanism responsible for the near-linear elastic deformation behavior of a dual-phase Ti-Nb alloy consisting of β and α″ phase with large recoverable strain was systematically elu...
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Article
Open AccessStudy on failure characteristics and evaluation index of aquifer shale based on energy evolution
The presence of abundant clay components and microporous structure in shale results in its high hydrophilicity, making a water-rich environment inevitable in petroleum exploration projects. Therefore, it is cr...
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Article
Open AccessStructural bases of inhibitory mechanism of CaV1.2 channel inhibitors
The voltage-gated calcium channel CaV1.2 is essential for cardiac and vessel smooth muscle contractility and brain function. Accumulating evidence demonstrates that malfunctions of CaV1.2 are involved in brain an...
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Article
Open AccessEffect of early peri-operative arterial lactate concentration level ratios on post-hepatectomy liver failure
Post-hepatectomy liver failure (PHLF) is a serious complication after hepatectomy and a major cause of death. The current criteria for PHLF diagnosis (ISGLS consensus) require laboratory data of elevated INR l...
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Article
Open AccessA von-Neumann-like photonic processor and its application in studying quantum signature of chaos
Photonic quantum computation plays an important role and offers unique advantages. Two decades after the milestone work of Knill-Laflamme-Milburn, various architectures of photonic processors have been propose...
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Article
Enantioselective sulfur(VI) fluoride exchange reaction of iminosulfur oxydifluorides
Linkage chemistry and functional molecules derived from the stereogenic sulfur(VI) centre have important applications in organic synthesis, bioconjugation, drug discovery, agrochemicals and polymeric materials...
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Article
Computational markers of risky decision-making predict for relapse to alcohol
Relapse remains the major challenge in treatment of alcohol use disorder (AUD). Aberrant decision-making has been found as important cognitive mechanism underlying relapse, but factors associated with relapse ...
