542 Result(s)
within
Life Sciences
Proteomics
**an Qi
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Article
CRISPR-array-mediated imaging of non-repetitive and multiplex genomic loci in living cells
Dynamic imaging of genomic loci is key for understanding gene regulation, but methods for imaging genomes, in particular non-repetitive DNAs, are limited. We developed CRISPRdelight, a DNA-labeling system base...
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Article
Open AccessGenome-wide association study for cashmere traits in Inner Mongolia cashmere goat population reveals new candidate genes and haplotypes
The cashmere goat industry is one of the main pillars of animal husbandry in Inner Mongolia Autonomous Region, and plays an irreplaceable role in local economic development. With the change in feeding methods ...
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Article
Open AccessMetabolic differences in MSTN and FGF5 dual-gene edited sheep muscle cells during myogenesis
Dynamic metabolic reprogramming occurs at different stages of myogenesis and contributes to the fate determination of skeletal muscle satellite cells (MuSCs). Accumulating evidence suggests that mutations in m...
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Article
Open AccessMulti-omic analysis reveals the effects of interspecific hybridization on the synthesis of seed reserve polymers in a Triticum turgidum ssp. durum × Aegilops sharonensis amphidiploid
Wheat grain endosperm is mainly composed of proteins and starch. The contents and the overall composition of seed storage proteins (SSP) markedly affect the processing quality of wheat flour. Polyploidization ...
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Open AccessGenome-wide characterization and metabolite profiling of Cyathus olla: insights into the biosynthesis of medicinal compounds
Cyathus olla, belonging to the genus Cyathus within the order Agaricales, is renowned for its bird's nest-like fruiting bodies and has been utilized in folk medicine. However, its genome remains poorly understood...
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Article
Open AccessA comprehensive analysis of the WRKY family in soybean and functional analysis of GmWRKY164-GmGSL7c in resistance to soybean mosaic virus
Soybean mosaic disease caused by soybean mosaic virus (SMV) is one of the most devastating and widespread diseases in soybean producing areas worldwide. The WRKY transcription factors (TFs) are widely involved in...
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Article
Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
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Open AccessWhole-genome sequencing reveals genomic diversity and selection signatures in **a’nan cattle
The crossbreeding of specialized beef cattle breeds with Chinese indigenous cattle is a common method of genetic improvement. **a’nan cattle, a crossbreed of Charolais and Nanyang cattle, is China’s first spec...
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Article
Open AccessSingle-nucleus analysis reveals microenvironment-specific neuron and glial cell enrichment in Alzheimer’s disease
Alzheimer’s disease (AD) is a complicated neurodegenerative disease. Neuron-glial cell interactions are an important but not fully understood process in the progression of AD. We used bioinformatic methods to ...
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Open AccessGenome-wide analysis of filamentous temperature-sensitive H protease (ftsH) gene family in soybean
The filamentous temperature-sensitive H protease (ftsH) gene family belongs to the ATP-dependent zinc metalloproteins, and ftsH genes play critical roles in plant chloroplast development and photosynthesis.
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Open AccessGenome-wide identification and analysis of the cotton ALDH gene family
Aldehyde dehydrogenases (ALDHs) are a family of enzymes that catalyze the oxidation of aldehyde molecules into the corresponding carboxylic acid, regulate the balance of aldehydes and protect plants from the p...
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Open AccessGenome-wide association analysis explores the genetic loci of amino acid content in duck’s breast muscle
Amino acids are the basic components of protein and an important index to evaluate meat quality. With the rapid development of genomics, candidate regions and genes affecting amino acid content in livestock an...
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Article
Open AccessComprehensive identification of maize ZmE2F transcription factors and the positive role of ZmE2F6 in response to drought stress
The early 2 factor (E2F) family is characterized as a kind of transcription factor that plays an important role in cell division, DNA damage repair, and cell size regulation. However, its stress response has n...
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Open AccessIntegrated mRNA and miRNA analysis reveals the regulatory network of oxidative stress and inflammation in Coilia nasus brains during air exposure and salinity mitigation
Air exposure is an inevitable source of stress that leads to significant mortality in Coilia nasus. Our previous research demonstrated that adding 10‰ NaCl to aquatic water could enhance survival rates, albeit th...
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Open AccessThe suppression of HSPA8 attenuates NLRP3 ubiquitination through SKP2 to promote pyroptosis in sepsis-induced lung injury
Acute lung injury (ALI) is strongly associated with hospitalization and mortality in patients with sepsis. Recent evidence suggests that pyroptosis mediated by NLRP3(NOD-, LRR- and pyrin domain-containing 3) i...
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Open AccessscCompressSA: dual-channel self-attention based deep autoencoder model for single-cell clustering by compressing gene–gene interactions
Single-cell clustering has played an important role in exploring the molecular mechanisms about cell differentiation and human diseases. Due to highly-stochastic transcriptomics data, accurate detection of cel...
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Open AccessIntegrative analysis of the metabolome and transcriptome provides insights into the mechanisms of lignan biosynthesis in Herpetospermum pedunculosum (Cucurbitaceae)
Herpetospermum pedunculosum (Ser.) C. B. Clarke is a traditional Chinese herbal medicine that heavily relies on the lignans found in its dried ripe seeds (Herpetospermum caudigerum), which have antioxidant and h...
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Open AccessGenome-wide identification, characterization and expression of C2H2 zinc finger gene family in Opisthopappus species under salt stress
The C2H2 zinc finger protein family plays important roles in plants. However, precisely how C2H2s function in Opisthopappus (Opisthopappus taihangensis and Opisthopappus longilobus) remains unclear.
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Open AccessMitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by overexpression or dysregulation of the MYC oncogene this pro...
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Open AccessGenome-wide analysis and expression profiling of the HD-ZIP gene family in kiwifruit
The homeodomain-leucine zipper (HD-Zip) gene family plays a pivotal role in plant development and stress responses. Nevertheless, a comprehensive characterization of the HD-Zip gene family in kiwifruit has bee...
