164 Result(s)

Article

Mesenteric lymph nodes: a critical site for the up-regulatory effect of hUC-MSCs on Treg cells by producing TGF-β1 in colitis treatment

Mesenchymal stem cells (MSCs) demonstrate a wide range of therapeutic capabilities in the treatment of inflammatory bowel disease (IBD). The intraperitoneal injection of MSCs has exhibited superior therapeutic...

Qixiang Zhang, Zhu Zeng, Ning Wei, Yueyan Su, **g Wang… in Stem Cell Research & Therapy (2024)

Article

Effects of Staphylococcus aureus on stem cells and potential targeted treatment of inflammatory disorders

Due to the advanced studies on stem cells in developmental biology, the roles of stem cells in the body and their phenotypes in related diseases have not been covered clearly. Meanwhile, with the intensive res...

Zi-xian Liu, Guan-qiao Liu, Ze-xin Lin, Ying-qi Chen… in Stem Cell Research & Therapy (2024)

Article

Improved therapeutic consistency and efficacy of CD317⁺ MSCs through stabilizing TSG6 by PTX3

Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expan...

Shaoquan Shi, Si Chen, Bowei Liang, Yumeng Li, Qi Ma… in Stem Cell Research & Therapy (2024)

Article

Grafted human-induced pluripotent stem cells-derived oligodendrocyte progenitor cells combined with human umbilical vein endothelial cells contribute to functional recovery following spinal cord injury

Spinal cord injury (SCI) is a devastating disease that causes extensive damage to oligodendrocytes and neurons leading to demyelination and axonal degeneration. In this study, we co-transplanted cell grafts co...

Qian Li, Sumei Liu, Tianqi Zheng, Mo Li, Boling Qi… in Stem Cell Research & Therapy (2024)

Article

CD317⁺ MSCs expanded with chemically defined media have enhanced immunological anti-inflammatory activities

Although both preclinical and clinical studies have shown the great application potential of MSCs (mesenchymal stem/stromal cells) in treating many kinds of diseases, therapeutic inconsistency resulting from c...

Jun Song, Qi Ma, Yumeng Li, **anqi Wang, Si Chen… in Stem Cell Research & Therapy (2024)

Article

Plasma proteomics-based biomarkers for predicting response to mesenchymal stem cell therapy in severe COVID-19

The objective of this study was to identify potential biomarkers for predicting response to MSC therapy by pre-MSC treatment plasma proteomic profile in severe COVID-19 in order to optimize treatment choice.

Tian-Tian Li, Wei-Qi Yao, Hai-Bo Dong, Ze-Rui Wang… in Stem Cell Research & Therapy (2023)

Article

sFgl2 gene-modified MSCs regulate the differentiation of CD4⁺ T cells in the treatment of autoimmune hepatitis

Autoimmune hepatitis (AIH) is a T-cell-mediated autoimmune liver disease that can lead to liver injury and has a poor long-term prognosis. Mesenchymal stromal cells (MSCs) have immunosuppressive effects and ca...

Wenbin Ji, Weiwei Wang, Peiyuan Li, Yanhong Liu… in Stem Cell Research & Therapy (2023)

Article

Correction: An integrated characterization of contractile, electrophysiological and structural cardiotoxicity of Sophora tonkinensis Gapnep. in human pluripotent stem cell-derived cardiomyocytes

Ruiying Wang, Min Wang, Shan Wang, Ke Yang, ** Zhou… in Stem Cell Research & Therapy (2023)

Article

Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis

Natural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral blood and cord blood, stem cell-derived NK cells offer an 'off-the-sh...

Wei Wen, **ang Chen, **n-Yi Shen, Hua-Yu Li, Feng Zhang… in Stem Cell Research & Therapy (2023)

Article

Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response

T helper 2 (Th2) cells are thought to play critical roles in allergic conjunctivitis (AC). They release inflammatory cytokines to promote an allergic response in AC. Due to individual heterogeneity and long-te...

Dongli Li, Qingjian Ou, Qi Shen, Michael Mingze Lu… in Stem Cell Research & Therapy (2023)

Article

HSP90, as a functional target antigen of a mAb 11C9, promotes stemness and tumor progression in hepatocellular carcinoma

Identification of promising targeted antigens that exhibited cancer-specific expression is a crucial step in the development of novel antibody-targeted therapies. We here aimed to investigate the anti-tumor ac...

Hui-Qi Liu, Li-**n Sun, Long Yu, Jun Liu, Li-Chao Sun… in Stem Cell Research & Therapy (2023)

Article

Nano-seq analysis reveals different functional tendency between exosomes and microvesicles derived from hUMSC

Extracellular vesicles (EVs) from human umbilical cord mesenchymal stem cells (hUMSCs) are widely considered to be the best mediators for cell-free therapy. An understanding of their composition, especially RN...

Dong Yu, Yue Mei, Ling Wang, Yunpeng Zhao, **ngfei Fan… in Stem Cell Research & Therapy (2023)

Article

The characteristics and medical applications of antler stem cells

Antlers are the only fully regenerable mammalian appendages whose annual renewal is initiated by antler stem cells (ASCs), defined as a specialized type of mesenchymal stem cells (MSCs) with embryonic stem cel...

Qi Liu, Jiannan Li, **ghui Chang, Yu Guo, Dacheng Wen in Stem Cell Research & Therapy (2023)

Article

Dendritic cells mediated by small extracellular vesicles derived from MSCs attenuated the ILC2 activity via PGE2 in patients with allergic rhinitis

Mesenchymal stromal cells-derived small extracellular vesicles (MSC-sEVs) have recently attracted considerable attention because of their therapeutic potential in various immune diseases. We previously reporte...

**ao-Qing Liu, Ya-Qi Peng, Long-**n Huang, Chan-Gu Li… in Stem Cell Research & Therapy (2023)