102 Result(s)

Article

Systemic delivery of oncolytic herpes virus using CAR-T cells enhances targeting of antitumor immuno-virotherapy

Recent studies have indicated that combining oncolytic viruses with CAR-T cells in therapy has shown superior anti-tumor effects, representing a promising approach. Nonetheless, the localized delivery method o...

Zongliang Zhang, Nian Yang, Long Xu, Huaqing Lu… in Cancer Immunology, Immunotherapy (2024)

Article

Establishment of orthotopic osteosarcoma animal models in immunocompetent rats through muti-rounds of in-vivo selection

Immunodeficient murine models are usually used as the preclinical models of osteosarcoma. Such models do not effectively simulate the process of tumorigenesis and metastasis. Establishing a suitable animal mod...

Mengyu Yao, Zehua Lei, Feng Peng, Donghui Wang, Mei Li, Guoqing Zhong… in BMC Cancer (2024)

Article

Beneficial effects of maintaining liver function during hepatic arterial infusion chemotherapy combined with tyrosine kinase and programmed cell death protein-1 inhibitors on the outcomes of patients with unresectable hepatocellular carcinoma

Combination therapy is the primary treatment for unresectable hepatocellular carcinoma (u-HCC). The hepatic functional reserve is also critical in the treatment of HCC. In this study, u-HCC was treated with co...

Yongqiang **ao, Wei Deng, Laihui Luo, Guoqing Zhu, ** **e, Yu Liu… in BMC Cancer (2024)

Article

Construction of a prognostic model for hepatocellular carcinoma patients receiving transarterial chemoembolization treatment based on the Tumor Burden Score

Patients with hepatocellular carcinoma (HCC) who undergo transarterial chemoembolization (TACE) may have varied outcomes based on their liver function and tumor burden diversity. This study aims to assess the ...

Jiawei Lin, Jie Li, Yifan Kong, Junhui Yang, Yunjie Zhang, Guoqing Zhu… in BMC Cancer (2024)

Article

Cytokine-based models for efficient differentiation between infection and cytokine release syndrome in patients with hematological malignancies

Although the efficacy of chimeric antigen receptor (CAR)-T cell therapy has been widely demonstrated, its clinical application is hampered by the complexity and fatality of its side effe...

Linqin Wang, Yuqi Lv, Linghui Zhou, Shenghao Wu… in Experimental Hematology & Oncology (2024)

Article

TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression

As a novel necrosis manner, ferroptosis has been increasingly reported to play a role in tumor progression and treatment, however, the specific mechanisms underlying its development in prostate cancer remain u...

Yu Zhang, Zhenlin Huang, Keqiang Li… in Journal of Experimental & Clinical Cancer … (2024)

Article

A compendium of genetic regulatory effects across pig tissues

The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms...

**yan Teng, Yahui Gao, Hongwei Yin, Zhonghao Bai, Shuli Liu… in Nature Genetics (2024)

Article

Pangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet

Broomcorn millet (Panicum miliaceum L.) is an orphan crop with the potential to improve cereal production and quality, and ensure food security. Here we present the genetic variations, population structure and di...

**feng Chen, Yang Liu, Minxuan Liu, Wenlei Guo, Yongqiang Wang… in Nature Genetics (2023)

Article

Development of a thyroid cancer prognostic model based on the mitophagy-associated differentially expressed genes

The prevalence of thyroid cancer (ThyC), a frequent malignant tumor of the endocrine system, has been rapidly increasing over time. The mitophagy pathway is reported to play a critical role in ThyC onset and p...

Wencong Sun, **nhui Wang, Guoqing Li, Chao Ding, Yichen Wang, Zijie Su… in Discover Oncology (2023)

Article

CircGNB1 facilitates the malignant phenotype of GSCs by regulating miR-515-5p/miR-582-3p-XPR1 axis

Glioma is the most common and aggressive primary malignant brain tumor. Circular RNAs (circRNAs) and RNA-binding proteins (RBPs) have been verified to mediate diverse biological behaviors in various human canc...

**peng Hu, Guoqing Zhang, Yongfeng Wang, Kai Xu, Lian Chen… in Cancer Cell International (2023)

Article

Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia

Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery, likely due to the widespread seizure network. Previous studies have primarily focused on the disrupt...

Yang Zheng, Cenglin Xu, **yi Sun, Wenjie Ming… in Signal Transduction and Targeted Therapy (2023)

Article

Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses

Liyan Sui, Letian Li, Yinghua Zhao… in Signal Transduction and Targeted Therapy (2023)

Article

Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

Mesenchymal stem cells (MSCs) are multipotent stromal cells that can be obtained from various human tissues and organs. They can differentiate into a wide range of cell types, including osteoblasts, adipocytes...

Zhengjun Lin, Yanlin Wu, Yiting Xu, Guoqing Li, Zhihong Li, Tang Liu in Molecular Cancer (2022)

Article

Associations of IFT20 and GM130 protein expressions with clinicopathological features and survival of patients with lung adenocarcinoma

Lung cancer is the leading cause of malignancy-related mortality and lung adenocarcinoma accounts for about 40% of lung malignancies. The aim of this study was to investigate the associations of intraflagellar...

Lianfeng Li, Yaobing Chen, Wei Liao, Qimei Yu, Hui Lin, Yuqin Shi, Ling Zhang… in BMC Cancer (2022)