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Article
Selenium in the treatment of mild-to-moderate Graves’ orbitopathy: a 5-year prospective controlled cohort study
Graves’ orbitopathy (GO) is the main extrathyroidal manifestation of Graves’ disease. However, limited studies have investigated the actual efficacy of selenium in GO therapy. This longitudinal study explored ...
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Article
Open AccessCARM30: China annual rapeseed maps at 30 m spatial resolution from 2000 to 2022 using multi-source data
Rapeseed is a critical cash crop globally, and understanding its distribution can assist in refined agricultural management, ensuring a sustainable vegetable oil supply, and informing government decisions. Chi...
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Article
Open AccessPhoto-induced intramolecular dearomative [5 + 4] cycloaddition of arenes for the construction of highly strained medium-sized-rings
Medium-sized-ring compounds have been recognized as challenging synthetic targets in organic chemistry. Especially, the difficulty of synthesis will be augmented if an E-olefin moiety is embedded. Recently, photo...
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Article
Open AccessSynthesis of 2D layered transition metal (Ni, Co) hydroxides via edge-on condensation
Layered transition metal hydroxides (LTMHs) with transition metal centers sandwiched between layers of coordinating hydroxide anions have attracted considerable interest for their potential in develo** clean...
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Article
Open AccessDual-level clustering ensemble algorithm with three consensus strategies
Clustering ensemble (CE), renowned for its robust and potent consensus capability, has garnered significant attention from scholars in recent years and has achieved numerous noteworthy breakthroughs. Neverthel...
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Article
Open AccessCobalt(III)-catalyzed asymmetric ring-opening of 7-oxabenzonorbornadienes via indole C–H functionalization
Asymmetric ring-opening of 7-oxabenzonorbornadienes is achieved via Co-catalyzed indole C–H functionalization. The utilization of chiral Co-catalyst consisting of a binaphthyl-derived trisubstituted cyclopenta...
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Article
Open AccessPhase-engineered cathode for super-stable potassium storage
The crystal phase structure of cathode material plays an important role in the cell performance. During cycling, the cathode material experiences immense stress due to phase transformation, resulting in capaci...
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Article
Effects of TSH suppressive therapy on bone mineral density (BMD) and bone turnover markers (BTMs) in patients with differentiated thyroid cancer in Northeast China: a prospective controlled cohort study
This study aimed to evaluate the effects of thyroid-stimulating hormone (TSH) suppressive therapy on bone mineral density (BMD) and bone turnover markers (BTMs) in differentiated thyroid cancer (DTC) patients ...
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Open AccessAn all-Africa dataset of energy model “supply regions” for solar photovoltaic and wind power
With solar and wind power generation reaching unprecedented growth rates globally, much research effort has recently gone into a comprehensive map** of the worldwide potential of these variable renewable ele...
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Article
Open AccessA steep switching WSe2 impact ionization field-effect transistor
The Fermi-Dirac distribution of carriers and the drift-diffusion mode of transport represent two fundamental barriers towards the reduction of the subthreshold slope (SS) and the optimization of the energy con...
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Article
Open AccessDietary exposure of radionuclides and heavy metals in adult residents in a high background natural radiation area using duplicate diet method
Intake of radionuclides and heavy metals through food consumption is one of the important pathways for long-term health considerations. In this paper, the dietary exposure to radionuclides (210Pb, 210Po, 226Ra, 2...
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Article
Open AccessInelastic phonon transport across atomically sharp metal/semiconductor interfaces
Understanding thermal transport across metal/semiconductor interfaces is crucial for the heat dissipation of electronics. The dominant heat carriers in non-metals, phonons, are thought to transport elastically...
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Article
Open AccessTranscription-independent regulation of STING activation and innate immune responses by IRF8 in monocytes
Sensing of cytosolic DNA of microbial or cellular/mitochondrial origin by cGAS initiates innate immune responses via the adaptor protein STING. It remains unresolved how the activity of STING is balanced betwe...
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Article
Open AccessIntrinsically fluorescent polyureas toward conformation-assisted metamorphosis, discoloration and intracellular drug delivery
Peptidomimetic polymers have attracted increasing interest because of the advantages of facile synthesis, high molecular tunability, resistance to degradation, and low immunogenicity. However, the presence of ...
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Article
Open AccessTargeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation
Sclerostin negatively regulates bone formation by antagonizing Wnt signalling. An antibody targeting sclerostin for the treatment of postmenopausal osteoporosis was approved by the U.S. Food and Drug Administr...
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Open AccessGlobal stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila
System-wide metabolic homeostasis is crucial for maintaining physiological functions of living organisms. Stable-isotope tracing metabolomics allows to unravel metabolic activity quantitatively by measuring th...
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Article
Open AccessMap** the wildland-urban interface in California using remote sensing data
Due to the mixed distribution of buildings and vegetation, wildland-urban interface (WUI) areas are characterized by complex fuel distributions and geographical environments. The behavior of wildfires occurrin...
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Article
Effects of Temperature and Confining Stress on the Hydraulic Fracturing Behavior of Granite: An Experimental and Numerical Study
Hydraulic fracturing technology has been widely applied to the exploitation of hot dry rock (HDR), and the understanding of hydraulic fracturing behavior of rocks is of great significance for improving the per...
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Article
Genome-edited powdery mildew resistance in wheat without growth penalties
Disruption of susceptibility (S) genes in crops is an attractive breeding strategy for conferring disease resistance1,2. However, S genes are implicated in many essential biological functions and deletion of thes...
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Open AccessTargeting miR-126 in inv(16) acute myeloid leukemia inhibits leukemia development and leukemia stem cell maintenance
Acute myeloid leukemia (AML) harboring inv(16)(p13q22) expresses high levels of miR-126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 expression through aberrant miR-126 transcription and...