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Open AccessTargeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways
The immune system initiates robust immune responses to defend against invading pathogens or tumor cells and protect the body from damage, thus acting as a fortress of the body. However, excessive responses cau...
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Open AccessAlternative approaches to target Myc for cancer treatment
The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively. Myc protein orchestrates diverse physi...
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Open AccessRNF141 interacts with KRAS to promote colorectal cancer progression
RING finger proteins (RNFs) play a critical role in cancer initiation and progression. RNF141 is a member of RNFs family; however, its clinical significance, roles, and mechanism in colorectal cancer (CRC) rem...