6 Result(s)
within
**Jie Yin
Cancer Research
Cell Biology
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Article
Open AccessLactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metastases. A better understanding how primary CoM disseminate to form metastases is urgently...
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Article
Open AccessSIRT4 is an independent prognostic factor in bladder cancer and inhibits bladder cancer growth by suppressing autophagy
Nucleosome-localized sirtuin 4 (SIRT4) was found to function as an oncogene and tumor suppressor gene in different tumors. However, the clinical significance of SIRT4 in bladder urothelial carcinoma (BLCA) has...
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Article
Open AccessDual effects of targeting S100A11 on suppressing cellular metastatic properties and sensitizing drug response in gastric cancer
S100A11 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. The dysregulated expression of the S100A11 gene has been implicated in tumour metastasis. However, the role of ...
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Article
Open AccessAlternative approaches to target Myc for cancer treatment
The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively. Myc protein orchestrates diverse physi...
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Article
Open AccessTargeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways
The immune system initiates robust immune responses to defend against invading pathogens or tumor cells and protect the body from damage, thus acting as a fortress of the body. However, excessive responses cau...
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Article
Open AccessCell-cycle synchronization reverses Taxol resistance of human ovarian cancer cell lines
Taxol is a powerful chemotherapy agent leading to mitotic arrest and cell death; however, its clinical efficacy has been hampered due to the development of drug resistance. Taxol specifically targets the cell ...
