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Bufalin alleviates acute kidney injury by regulating NLRP3 inflammasome-mediated pyroptosis

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  1. Article

    Open Access

    Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways

    The immune system initiates robust immune responses to defend against invading pathogens or tumor cells and protect the body from damage, thus acting as a fortress of the body. However, excessive responses cau...

    Jiaxin Liu, Yicheng Cheng, Ming Zheng… in Signal Transduction and Targeted Therapy (2021)

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  2. Article

    Open Access

    Alternative approaches to target Myc for cancer treatment

    The Myc proto-oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encodes the transcription factor c-Myc (hereafter Myc), N-Myc, and L-Myc, respectively. Myc protein orchestrates diverse physi...

    Chen Wang, Jiawei Zhang, Jie Yin, Yichao Gan… in Signal Transduction and Targeted Therapy (2021)

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  3. Article

    Open Access

    Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts

    Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metastases. A better understanding how primary CoM disseminate to form metastases is urgently...

    Jie Yin, Gabriel Forn-Cuní, Akshaya Mahalakshmi Surendran… in Angiogenesis (2024)

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