31 Result(s)
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**Jie Yin
Biomedicine, general
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Article
Open AccessLactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts
Conjunctival melanoma (CoM) is a rare but potentially lethal cancer of the eye, with limited therapeutic option for metastases. A better understanding how primary CoM disseminate to form metastases is urgently...
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Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons
The blood–brain barrier (BBB) restricts the systemic delivery of messenger RNAs (mRNAs) into diseased neurons. Although leucocyte-derived extracellular vesicles (EVs) can cross the BBB at inflammatory sites, i...
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Article
Open AccessEnsemble methods of rank-based trees for single sample classification with gene expression profiles
Building Single Sample Predictors (SSPs) from gene expression profiles presents challenges, notably due to the lack of calibration across diverse gene expression measurement technologies. However, recent resea...
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Article
Open AccessThe mechanism of ferroptosis and its related diseases
Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative s...
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Article
Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells
Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism, contributing to cellular heterogeneity and disease. Diverse mutations are associated with diverse clinical phenotypes, suggesti...
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Open AccessCDC50A might be a novel biomarker of epithelial ovarian cancer-initiating cells
The aim of this work was to screen and validate biomarkers of ovarian cancer-initiating cells to detect the mechanisms of recurrence of epithelial ovarian cancer (EOC).
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Article
Erratum to: In situ construction of thiol-silver interface for selectively electrocatalytic CO2 reduction
One funding number in the Acknowledgements section was unfortunately mistakenly used. This error did not affect any of the conclusions from the published paper.
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Article
Research and application advances in rehabilitation assessment of stroke
Stroke has a high incidence and disability rate, and rehabilitation is an effective means to reduce the disability rate of patients. To systematize rehabilitation assessment, which is the foundation for rehabi...
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Open AccessNext-day manufacture of a novel anti-CD19 CAR-T therapy for B-cell acute lymphoblastic leukemia: first-in-human clinical study
To improve clinical outcomes and shorten the vein-to-vein time of chimeric antigen receptor T (CAR-T) cells, we developed the FasT CAR-T (F-CAR-T) next-day manufacturing platform. We report the preclinical and...
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Article
Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations
The combination of single-cell transcriptomics with mitochondrial DNA variant detection can be used to establish lineage relationships in primary human cells, but current methods are not scalable to interrogat...
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Article
Open AccessNovel CD19 chimeric antigen receptor T cells manufactured next-day for acute lymphoblastic leukemia
Chimeric antigen receptor-engineered T (CAR-T) cells have shown promising efficacy in patients with relapsed/refractory B cell acute lymphoblastic leukemia (R/R B-ALL). However, challenges remain including lon...
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Article
Atomic-level correlation between the electrochemical performance of an oxygen-evolving catalyst and the effects of CeO2 functionalization
Herein, we prepared a bimetallic layered double hydroxide (FeCo LDH) featuring a dandelion-like structure. Anchoring of CeO2 onto FeCo LDH produced interfaces between the functionalizing CeO2 and the parent LDH. ...
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Article
In situ construction of thiol-silver interface for selectively electrocatalytic CO2 reduction
Electrochemical CO2 reduction (ECR) is one of the most effective methods to obtain carbonaceous chemicals and reduce greenhouse gases passingly under the ambient condition. However, efficient electrocatalysts fea...
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Article
Ru(bpy)32+-sensitized {001} facets LiCoO2 nanosheets catalyzed CO2 reduction reaction with 100% carbonaceous products
Photosensitized heterogeneous CO2 reduction (PHCR) has emerged as a promising means to convert CO2 into valuable chemicals, however, challenged by the relatively low carbonaceous product selectivity caused by the...
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Article
Inter-facet composition modulation of III-nitride nanowires over pyramid textured Si substrates by stationary molecular beam epitaxy
InGaN nanowires (NWs) are grown on pyramid textured Si substrates by stationary plasma-assisted molecular beam epitaxy (PA-MBE). The incidence angles of the highly directional source beams vary for different p...
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Article
Open AccessProtocol for expanded indications of endoscopic submucosal dissection for early gastric cancer in China: a multicenter, ambispective, observational, open-cohort study
The main treatment methods for early gastric cancer (EGC) include endoscopic submucosal dissection (ESD) and radical gastrectomy. However, appropriate treatment for patients who exceed the absolute indications...
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Article
Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia
Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the molecular mechanisms that underlie abnormal eye develo...
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Article
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex diseases and disorders1. They are heritable2,3 and etiologically related4,5 behaviors that have been resistant to gene ...
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Article
Open AccessThe role of the apoptosis-related protein BCL-B in the regulation of mitophagy in hepatic stellate cells during the regression of liver fibrosis
The clearance of activated hepatic stellate cells (HSCs) by apoptosis is critical for the reversibility of hepatic fibrosis. Mitochondrial homeostasis is regulated by mitophagy, which is an efficient way of cl...
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Article
Remarkably enhanced water splitting activity of nickel foam due to simple immersion in a ferric nitrate solution
The development of a facile method to construct a high-performance electrode is of paramount importance to the application of alkaline water electrolysis. Here, we report that the activity of nickel foam (NF) ...
