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Open AccessAuthor Correction: On the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation
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Open AccessEnvironment-induced heritable variations are common in Arabidopsis thaliana
Parental or ancestral environments can induce heritable phenotypic changes, but whether such environment-induced heritable changes are a common phenomenon remains unexplored. Here, we subject 14 genotypes of Arab...
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Open AccessOn the mechanism of wogonin against acute monocytic leukemia using network pharmacology and experimental validation
Wogonin is a natural flavone compound from the plant Scutellaria baicalensis, which has a variety of pharmacological activities such as anti-cancer, anti-virus, anti-inflammatory, and immune regulation. Howeve...
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Open AccessUltrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections
Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor b...
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Open AccessUnraveling the genetic architecture of congenital vertebral malformation with reference to the develo** spine
Congenital vertebral malformation, affecting 0.13–0.50 per 1000 live births, has an immense locus heterogeneity and complex genetic architecture. In this study, we analyze exome/genome sequencing data from 873...
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Open AccessMagnaporthe oryzae effector MoSPAB1 directly activates rice Bsr-d1 expression to facilitate pathogenesis
Fungal pathogens typically use secreted effector proteins to suppress host immune activators to facilitate invasion. However, there is rarely evidence supporting the idea that fungal secretory proteins contrib...
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Latent human herpesvirus 6 is reactivated in CAR T cells
Cell therapies have yielded durable clinical benefits for patients with cancer, but the risks associated with the development of therapies from manipulated human cells are understudied. For example, we lack a ...
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Open AccessLarge eddy simulation on wind-induced interference effects of staggered chamfered square cylinders
Chamfered corners in buildings are the main means to reduce the control effect of wind load on the structure, and the interference effect of chamfered buildings cannot be ignored. At present, only the mutual i...
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Open AccessExperimental study on the axial tensile properties of polypropylene fiber reinforced concrete
In order to study the axial tensile properties of polypropylene fiber reinforced concrete, an axial tensile test device for concrete is developed in this paper. The device is composed of three parts: rigid fra...
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Open AccessA prophylactic TXA administration effectively reduces the risk of intraoperative bleeding during open management of pelvic and acetabular fractures
This study aimed to evaluate the efficacy of perioperative intravenous TXA in reducing blood loss in pelvic and acetabular fracture patients managed surgically. The study included 306 consecutive patients, div...
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Open AccessAngle-programmed tendril-like trajectories enable a multifunctional gripper with ultradelicacy, ultrastrength, and ultraprecision
Achieving multicapability in a single soft gripper for handling ultrasoft, ultrathin, and ultraheavy objects is challenging due to the tradeoff between compliance, strength, and precision. Here, combining expe...
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Open AccessReply to: The G protein preference of orexin receptors is currently an unresolved issue
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Open AccessElectrosynthesis of chlorine from seawater-like solution through single-atom catalysts
The chlor-alkali process plays an essential and irreplaceable role in the modern chemical industry due to the wide-ranging applications of chlorine gas. However, the large overpotential and low selectivity of ...
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Open AccessUnderstanding the sulphur-oxygen exchange process of metal sulphides prior to oxygen evolution reaction
Dynamic reconstruction of metal sulphides during electrocatalytic oxygen evolution reaction (OER) has hampered the acquisition of legible evidence for comprehensively understanding the phase-transition mechani...
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Open AccessThe built-in electric field across FeN/Fe3N interface for efficient electrochemical reduction of CO2 to CO
Nanostructured metal-nitrides have attracted tremendous interest as a new generation of catalysts for electroreduction of CO2, but these structures have limited activity and stability in the reduction condition. ...
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Open AccessAuthor Correction: Deciphering the atomic-scale structural origin for large dynamic electromechanical response in lead-free Bi0.5Na0.5TiO3-based relaxor ferroelectrics
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Co-opting signalling molecules enables logic-gated control of CAR T cells
Although chimeric antigen receptor (CAR) T cells have altered the treatment landscape for B cell malignancies, the risk of on-target, off-tumour toxicity has hampered their development for solid tumours becaus...
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Open AccessDiagnostic accuracy of metagenomic next-generation sequencing in diagnosing infectious diseases: a meta-analysis
Many common pathogens are difficult or impossible to detect using conventional microbiological tests. However, the rapid and untargeted nature of metagenomic next-generation sequencing (mNGS) appears to be a p...
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Open AccessPhoto-induced stress relaxation in reconfigurable disulfide-crosslinked supramolecular films visualized by dynamic wrinkling
Stress relaxation in reconfigurable supramolecular polymer networks is strongly related to intermolecular behavior. However, the relationship between molecular motion and macroscopic mechanics is usually vague...
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Open AccessGenetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1–4. These substances are used across the...