17 Result(s)
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Open AccessSpatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex
Single cell approaches have increased our knowledge about the cell type composition of the non-human primate (NHP), but a detailed characterization of area-specific regulatory features remains outstanding. We ...
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Open AccessMicroglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice
Microglia are important immune cells in the central nervous system (CNS) that undergo turnover throughout the lifespan. If microglial debris is not removed in a timely manner, accumulated debris may influence ...
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Open AccessStructural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2
Arrestins recognize different receptor phosphorylation patterns and convert this information to selective arrestin functions to expand the functional diversity of the G protein-coupled receptor (GPCR) superfam...
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Open AccessStructural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
Sterol O-acyltransferase 1 (SOAT1) is an endoplasmic reticulum (ER) resident, multi-transmembrane enzyme that belongs to the membrane-bound O-acyltransferase (MBOAT) family. It catalyzes the esterification of cho...
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Open AccessNKG2A is a NK cell exhaustion checkpoint for HCV persistence
Exhaustion of cytotoxic effector natural killer (NK) and CD8+ T cells have important functions in the establishment of persistent viral infections, but how exhaustion is induced during chronic hepatitis C virus (...
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Open AccessFluorescent Fe Embedded Magnetic Nanodiamonds Made by Ion Implantation
We demonstrate fluorescent Fe embedded magnetic nanodiamonds by ion implantation and two-step annealing. The diamond characteristics with a highly ordered core and a graphite surface layer are maintained after...
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Open AccessFe Doped Magnetic Nanodiamonds Made by Ion Implantation as Contrast Agent for MRI
We report in this paper a new MRI contrast agent based on magnetic nanodiamonds fabricated by Fe ion implantation. The Fe atoms that are implanted into the nanodiamonds are not in direct contact with the outsi...
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Open AccessPlatelet distribution width correlates with prognosis of non-small cell lung cancer
Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim ...
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Open AccessHigh-efficiency broadband second harmonic generation in single hexagonal GaAs nanowire
In this paper, we investigate second harmonic generation in a single hexagonal GaAs nanowire. An excellent frequency converter based on this nanowire excited using a femtosecond laser is demonstrated to operat...
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Open AccessYields and Nutritional of Greenhouse Tomato in Response to Different Soil Aeration Volume at two depths of Subsurface drip irrigation
This study investigated the effects of 4 aeration levels (varied by injection of air to the soil through subsurface irrigation lines) at two subsurface irrigation line depths (15 and 40 cm) on plant growth, yi...
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Open AccesstRNA-Derived Small Non-Coding RNAs in Response to Ischemia Inhibit Angiogenesis
Ischemic injuries will lead to necrotic tissue damage and post-ischemia angiogenesis plays critical roles in blood flow restoration and tissue recovery. Recently, several types of small RNAs have been reported...
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Open AccessCorrection: Corrigendum: Magmatic record of India-Asia collision
New geochronological and geochemical data on magmatic activity from the India-Asia collision zone enables recognition of a distinct magmatic flare-up event that we ascribe to slab breakoff. This tie-point in t...
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Article
Open AccessMultiple regulation pathways and pivotal biological functions of STAT3 in cancer
STAT3 is both a transcription activator and an oncogene that is tightly regulated under normal physiological conditions. However, abundant evidence indicates that STAT3 is persistently activated in several can...
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Open AccessMagmatic record of India-Asia collision
New geochronological and geochemical data on magmatic activity from the India-Asia collision zone enables recognition of a distinct magmatic flare-up event that we ascribe to slab breakoff. This tie-point in t...
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Open AccessLipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers
Schisandrin B (SchB) is one of the most abundant bioactive dibenzocyclooctadiene derivatives found in the fruit of Schisandra chinensis. Here, we investigated the potential therapeutic effects of SchB on non-alco...
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Open AccessIsotopic evidence for continental ice sheet in mid-latitude region in the supergreenhouse Early Cretaceous
Cretaceous represents one of the hottest greenhouse periods in the Earth's history, but some recent studies suggest that small ice caps might be present in non-polar regions during certain periods in the Early...
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Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
