75 Result(s)
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Alzheimer Neurofibrillary Degeneration: A Feasible and Key Target for Therapeutics
Independent of the etiology, i.e. whether genetic or non-genetic, Alzheimer disease (AD) is characterized histopathologically by the intraneuronal accumulation of paired helical filaments (PHF), forming neurof...
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Effect of xiaoke granule on blood sugar and blood rheological property in experimental diabetic animals
To study the pharmacological effect of **aoke Granule on blood sugar and blood rheological property in the diabetic animals.
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Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration
The major component of Alzheimer's disease (AD) neurofibrillary tangles (NFTs) is abnormally hyperphosphorylated tau aggregated as paired helical filaments (PHFs). Cell division cycle (cdc) 2 kinase is one of...
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Protective effect of ecdysterone on PC12 cells cytotoxicity induced by Beta-amyloid25–35
Objective: To examine the protective effect of ecdysterone (ECR) against beta-amyloid peptide fragment25–35 (Aß25–35)-induced PC12 cells cytotoxicity, and to further explore its mechanism.Methods: Experimental PC...
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Open AccessThe role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
The gene encoding the minibrain kinase/dual-specificity tyrosine phosphorylated and regulated kinase 1A (DYRK1A) is located in the Down syndrome (DS) critical region of chromosome 21. The third copy of DYRK1A is ...
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Mechanisms of tau-induced neurodegeneration
Alzheimer disease (AD) and related tauopathies are histopathologically characterized by a specific type of slow and progressive neurodegeneration, which involves the abnormal hyperphosphorylation of the microt...
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Targeting Tau Protein in Alzheimer’s Disease
Alzheimer’s disease (AD) is characterized histopathologically by numerous neurons with neurofibrillary tangles and neuritic (senile) amyloid-β (Aβ) plaques, and clinically by progressive dementia. Although Aβ ...
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Effects of Bushen Tongmai Recipe (补肾通脉方) on protein kinase Bα expression in polycystic ovary rats with insulin resistance
To observe the effects of Bushen Tongmai Recipe (补肾通脉方, BSTMR) on mRNA and protein expressions of protein kinase B alpha (PKB α) in hepatic, adipose, muscular, and ovarian tissues of polycystic ovary (PCO) rat...
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Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer
Adjuvant chemotherapy for stage II colon cancer remains controversial but may be considered for patients with high-risk features. Recent studies have shown that elevated neutrophil to lymphocyte ratio (NLR) is...
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The effect of COX-2 inhibitor on capecitabine-induced hand–foot syndrome in patients with stage II/III colorectal cancer: a phase II randomized prospective study
Hand–foot syndrome (HFS) is a common adverse event that can be induced by capecitabine. It is hypothesized that capecitabine (Hoffmann-La Roche Inc.) based chemotherapy can cause overexpression of COX-2 in tum...
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Excess nicotinamide inhibits methylation-mediated degradation of catecholamines in normotensives and hypertensives
Nicotinamide and catecholamines are both degraded by S-adenosylmethionine-dependent methylation. Whether excess nicotinamide affects the degradation of catecholamines is unknown. The aim of this study was to inve...
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Open AccessAmbulatory ECG-based T-wave alternans and heart rate turbulence can predict cardiac mortality in patients with myocardial infarction with or without diabetes mellitus
Many patients who survive a myocardial infarction (MI) remain at risk of sudden cardiac death despite revascularization and optimal medical treatment. We used the modified moving average (MMA) method to assess...
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A life dedicated to Alzheimer’s disease research: in memory of Inge Grundke-Iqbal (1937–2012)
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Open AccessThe role of high mobility group box chromosomal protein 1 expression in the differential diagnosis of hepatic actinomycosis: a case report
Primary hepatic actinomycosis is a rare disease, but is important in the differential diagnosis of hepatoma in endemic areas. As high mobility group box chromosomal protein 1 plays an important role in the pat...
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Status and trends of diabetes in Chinese children: analysis of data from 14 medical centers
Childhood diabetes has become a growing concern. We conducted a study to evaluate the status and trend of diabetes from 14 medical centers in China. Pre-diabetic status among obese children was also noted.
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Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey
The aim of this study is to investigate the remission rate of rheumatoid arthritis (RA) in China and identify its potential determinants. A multi-center cross-sectional study was conducted from July 2009 to Ja...
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Condylar and occlusal changes after high condylectomy and orthodontic treatment for condylar hyperplasia
Condylar hyperplasia (CH) of human temporomandibular joint (TMJ) often occurs unilaterally, and causes occlusal disturbance and facial asymmetry. The purpose of this study was to compare the effects of high co...
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Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice
Sporadic Alzheimer’s disease (AD) is a multifactorial metabolic brain disorder characterized by progressive neurodegeneration. Decreased brain energy and glucose metabolism occurs before the appearance of AD s...
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Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies
Intraneuronal accumulation of abnormally hyperphosphorylated tau in the brain is a histopathological hallmark of Alzheimer’s disease and a family of related neurodegenerative disorders collectively called tauo...
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Strain/strain rate imaging of impaired left atrial function in patients with metabolic syndrome
Left ventricular (LV) dysfunction has been demonstrated in patients with metabolic syndrome (MetS). However, alterations in left atrial (LA) function in MetS are unknown. We aimed to use strain/strain rate (SR...
