48 Result(s)

Article

An atlas of epithelial cell states and plasticity in lung adenocarcinoma

Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies¹. Here we studied 246,102 single epithelial cells from 16 early-stage LU...

Guangchun Han, Ansam Sinjab, Zahraa Rahal, Anne M. Lynch… in Nature (2024)

Article

Topological electronic structure and spin texture of quasi-one-dimensional higher-order topological insulator Bi₄Br₄

The notion of topological insulators (TIs), characterized by an insulating bulk and conducting topological surface states, can be extended to higher-order topological insulators (HOTIs) hosting gapless modes l...

Wenxuan Zhao, Ming Yang, Runzhe Xu, **an Du, Yidian Li, Kaiyi Zhai… in Nature Communications (2023)

Article

IRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice

Cardiac fibrosis is a common feature of chronic heart failure. Iroquois homeobox (IRX) family of transcription factors plays important roles in heart development; however, the role of IRX2 in cardiac fibrosis ...

Zhen-Guo Ma, Yu-Pei Yuan, Di Fan, **n Zhang, Teng Teng, Peng Song… in Nature Communications (2023)

Article

Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H₂O₂ → ‧OH for tumoral therapy. Unfortunately, H₂O₂ is often taken from the limited endogenous supply of H₂O₂ in can...

Liu-Chun Wang, Pei-Yu Chiou, Ya-** Hsu, Chin-Lai Lee… in Nature Communications (2023)

Article

Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma

Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-bas...

Miao Yan, Qing Chen, Tianyi Liu, **aofeng Li, Peng Pei, Lei Zhou… in Nature Communications (2023)

Article

Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S

Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in gene regulation^1–4. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation on lysine 36 (H3K36me3) and deacety...

Haipeng Guan, Pei Wang, Pei Zhang, Chun Ruan, Yutian Ou, Bo Peng, **angdong Zheng… in Nature (2023)

Article

Engineering antiviral immune-like systems for autonomous virus detection and inhibition in mice

The ongoing COVID-19 pandemic has demonstrated that viral diseases represent an enormous public health and economic threat to mankind and that individuals with compromised immune systems are at greater risk of...

Yidan Wang, Ying Xu, Chee Wah Tan, Longliang Qiao, Wan Ni Chia… in Nature Communications (2022)

Article

Antibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens

Antibodies recognize protein antigens with exquisite specificity in a complex aqueous environment, where interfacial waters are an integral part of the antibody–protein complex interfaces. In this work, we elu...

Hung-Pin Peng, Hung-Ju Hsu, Chung-Ming Yu, Fei-Hung Hung… in Scientific Reports (2022)

Article

The burden and trend of gastric cancer and possible risk factors in five Asian countries from 1990 to 2019

The burdens and trends of gastric cancer are poorly understood, especially in high-prevalence countries. Based on the Global Burden of Disease Study 2019, we analyzed the incidence, death, and possible risk fa...

Fei-Long Ning, Jun Lyu, Jun-Peng Pei, Wan-Jie Gu, Nan-Nan Zhang… in Scientific Reports (2022)

Article

Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants

Omicron (B.1.1.529), the most heavily mutated SARS-CoV-2 variant so far, is highly resistant to neutralizing antibodies, raising concerns about the effectiveness of antibody therapies and vaccines^1,2. Here we exa...

Kang Wang, Zi**g Jia, Linilin Bao, Lei Wang, Lei Cao, Hang Chi, Yaling Hu… in Nature (2022)

Article

Author Correction: Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

Wei-Liang Liu, Chia-Wei Hsu, Shih-Peng Chan, Pei-Shi Yen… in Scientific Reports (2022)

Article

Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

The areas where dengue virus (DENV) is endemic have expanded rapidly, driven in part by the global spread of Aedes species, which act as disease vectors. DENV replicates in the mosquito midgut and is disseminated...

Wei-Liang Liu, Chia-Wei Hsu, Shih-Peng Chan, Pei-Shi Yen… in Scientific Reports (2021)

Article

Visualizing designer quantum states in stable macrocycle quantum corrals

Creating atomically precise quantum architectures with high digital fidelity and desired quantum states is an important goal in a new era of quantum technology. The strategy of creating these quantum nanostruc...

**nnan Peng, Harshitra Mahalingam, Shaoqiang Dong, **o Mutombo… in Nature Communications (2021)

Article

Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries

Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and hence there are increasing needs to develop MSLN-targeting strategies for cancer therapeutics. Antibody–drug conjugates...

Hung-Ju Hsu, Chao-** Tung, Chung-Ming Yu, Chi-Yung Chen… in Scientific Reports (2021)

Article

Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL)

USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the ...

Timothy I. Shaw, Li Dong, Liqing Tian, Chenxi Qian, Yu Liu… in Scientific Reports (2021)

Article

Characterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing

The remarkable advances in next-generation sequencing technology have enabled the wide usage of sequencing as a clinical tool. To promote the advance of precision oncology for breast cancer in China, here we r...

Guan-Tian Lang, Yi-Zhou Jiang, **-**u Shi, Fan Yang… in Nature Communications (2020)

Article

Author Correction: End-to-end vascular anastomosis using a novel magnetic compression device in rabbits: a preliminary study

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Qiang Lu, Kang Liu, Wei Zhang, Tao Li, Ai-Hua Shi, Hong-Fan Ding… in Scientific Reports (2020)

Article

Purification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring

We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular vesicle (EV) purification system for early detection of HCC by performing digital scoring on the purified EVs. Earlier...

Na Sun, Yi-Te Lee, Ryan Y. Zhang, Rueihung Kao, Pai-Chi Teng… in Nature Communications (2020)

Article

Author Correction: Relative posture between head and finger determines perceived tactile direction of motion

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Yueh-Peng Chen, Chun-I. Yeh, Tsung-Chi Lee, Jian-Jia Huang… in Scientific Reports (2020)