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Open AccessAn atlas of epithelial cell states and plasticity in lung adenocarcinoma
Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies1. Here we studied 246,102 single epithelial cells from 16 early-stage LU...
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Article
Open AccessTopological electronic structure and spin texture of quasi-one-dimensional higher-order topological insulator Bi4Br4
The notion of topological insulators (TIs), characterized by an insulating bulk and conducting topological surface states, can be extended to higher-order topological insulators (HOTIs) hosting gapless modes l...
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Article
Subsecond periodic radio oscillations in a microquasar
Powerful relativistic jets are one of the ubiquitous features of accreting black holes in all scales1–3. GRS 1915 + 105 is a well-known fast-spinning black-hole X-ray binary4 with a relativistic jet, termed a ‘mi...
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Open AccessIRX2 regulates angiotensin II-induced cardiac fibrosis by transcriptionally activating EGR1 in male mice
Cardiac fibrosis is a common feature of chronic heart failure. Iroquois homeobox (IRX) family of transcription factors plays important roles in heart development; however, the role of IRX2 in cardiac fibrosis ...
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Open AccessPrussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments
Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in can...
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Open AccessSite-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma
Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-bas...
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Article
Open AccessDiverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S
Context-dependent dynamic histone modifications constitute a key epigenetic mechanism in gene regulation1–4. The Rpd3 small (Rpd3S) complex recognizes histone H3 trimethylation on lysine 36 (H3K36me3) and deacety...
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Article
Open AccessEngineering antiviral immune-like systems for autonomous virus detection and inhibition in mice
The ongoing COVID-19 pandemic has demonstrated that viral diseases represent an enormous public health and economic threat to mankind and that individuals with compromised immune systems are at greater risk of...
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Article
Open AccessAntibody CDR amino acids underlying the functionality of antibody repertoires in recognizing diverse protein antigens
Antibodies recognize protein antigens with exquisite specificity in a complex aqueous environment, where interfacial waters are an integral part of the antibody–protein complex interfaces. In this work, we elu...
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Open AccessThe burden and trend of gastric cancer and possible risk factors in five Asian countries from 1990 to 2019
The burdens and trends of gastric cancer are poorly understood, especially in high-prevalence countries. Based on the Global Burden of Disease Study 2019, we analyzed the incidence, death, and possible risk fa...
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Article
Open AccessMemory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants
Omicron (B.1.1.529), the most heavily mutated SARS-CoV-2 variant so far, is highly resistant to neutralizing antibodies, raising concerns about the effectiveness of antibody therapies and vaccines1,2. Here we exa...
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Open AccessAuthor Correction: Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus
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Open AccessTransgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus
The areas where dengue virus (DENV) is endemic have expanded rapidly, driven in part by the global spread of Aedes species, which act as disease vectors. DENV replicates in the mosquito midgut and is disseminated...
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Article
Open AccessVisualizing designer quantum states in stable macrocycle quantum corrals
Creating atomically precise quantum architectures with high digital fidelity and desired quantum states is an important goal in a new era of quantum technology. The strategy of creating these quantum nanostruc...
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Open AccessEradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries
Mesothelin (MSLN) is an attractive candidate of targeted therapy for several cancers, and hence there are increasing needs to develop MSLN-targeting strategies for cancer therapeutics. Antibody–drug conjugates...
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Open AccessIntegrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL)
USP7, which encodes a deubiquitylating enzyme, is among the most frequently mutated genes in pediatric T-ALL, with somatic heterozygous loss-of-function mutations (haploinsufficiency) predominantly affecting the ...
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Open AccessCharacterization of the genomic landscape and actionable mutations in Chinese breast cancers by clinical sequencing
The remarkable advances in next-generation sequencing technology have enabled the wide usage of sequencing as a clinical tool. To promote the advance of precision oncology for breast cancer in China, here we r...
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Open AccessAuthor Correction: End-to-end vascular anastomosis using a novel magnetic compression device in rabbits: a preliminary study
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessPurification of HCC-specific extracellular vesicles on nanosubstrates for early HCC detection by digital scoring
We report a covalent chemistry-based hepatocellular carcinoma (HCC)-specific extracellular vesicle (EV) purification system for early detection of HCC by performing digital scoring on the purified EVs. Earlier...
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Open AccessAuthor Correction: Relative posture between head and finger determines perceived tactile direction of motion
An amendment to this paper has been published and can be accessed via a link at the top of the paper.