48 Result(s)
within
English
Science, Humanities and Social Sciences, multidisciplinary
Science, Humanities and Social Sciences, multidisciplinary
**-peng Pei
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Article
Open AccessCMOS-based carbon nanotube pass-transistor logic integrated circuits
Field-effect transistors based on carbon nanotubes have been shown to be faster and less energy consuming than their silicon counterparts. However, ensuring these advantages are maintained for integrated circu...
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Open AccessStructure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine
ELIC, the pentameric ligand-gated ion channel from Erwinia chrysanthemi, is a prototype for Cys-loop receptors. Here we show that acetylcholine is a competitive antagonist for ELIC. We determine the acetylcholine...
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Article
Open AccessInterferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals
The SNP rs12252-C allele alters the function of interferon-induced transmembrane protein-3 increasing the disease severity of influenza virus infection in Caucasians, but the allele is rare. However, rs12252-C...
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Open AccessThe effect of La2O3 in Tm3+-doped germanate-tellurite glasses for ~2 μm emission
A germanate-tellurite glass (GeO2-TeO2-K2O-Nb2O5-La2O3) with thulium do** has been investigated for application as a laser material around 2.0 μm regions. Under the 808 nm laser diode pumped, intense 1.8 μm emi...
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Open AccessInterferon regulatory factor 9 is critical for neointima formation following vascular injury
Interferon regulatory factor 9 (IRF9) has various biological functions and regulates cell survival; however, its role in vascular biology has not been explored. Here we demonstrate a critical role for IRF9 in ...
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Open AccessSatellite telemetry and social modeling offer new insights into the origin of primate multilevel societies
Multilevel societies (MLS), in which polygynous reproductive units are nested in a larger social matrix, represent a highly complex social system documented only in a small number of mammalian species. Using l...
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Correction: Corrigendum: Interferon regulatory factor 9 is critical for neointima formation following vascular injury
Nature Communications 5: Article number: 5160 (2014); Published: 16 October 2014; Updated: 01 April 2015 The value of the relative luciferase activity of RASMCs infected with AdshIRF9 and AdshSIRT1 in Suppleme...
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Open AccessBoth TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs
β-Thalassemia is one of the most common genetic blood diseases and is caused by either point mutations or deletions in the β-globin (HBB) gene. The generation of patient-specific induced pluripotent stem cells (i...
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Open AccessCognitive dysfunction and health-related quality of life among older Chinese
We aimed to assess the association of cognitive dysfunction with health-related quality of life (HRQOL) among older adults in China. We analyzed community-based cross-sectional data of 5,557 Chinese individual...
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Open AccessMid-infrared laser emission from Cr:ZnS channel waveguide fabricated by femtosecond laser helical writing
The operation of a mid-infrared laser at 2244 nm in a Cr:ZnS polycrystalline channel waveguide fabricated using direct femtosecond laser writing with a helical movement technique is demonstrated. A maximum pow...
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Open AccessIntegrative topological analysis of mass spectrometry data reveals molecular features with clinical relevance in esophageal squamous cell carcinoma
Combining MS-based proteomic data with network and topological features of such network would identify more clinically relevant molecules and meaningfully expand the repertoire of proteins derived from MS anal...
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Open AccessResveratrol Inhibition of Rac1-Derived Reactive Oxygen Species by AMPK Decreases Blood Pressure in a Fructose-Induced Rat Model of Hypertension
Recent studies have reported that the activation of AMP-activated protein kinase (AMPK) suppressed oxidative stress. The aim of this study was to examine whether the activation of AMPK in the brain decreased R...
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Open AccessCombination of deep eutectic solvent and ionic liquid to improve biocatalytic reduction of 2-octanone with Acetobacter pasteurianus GIM1.158 cell
The efficient anti-Prelog asymmetric reduction of 2-octanone with Acetobacter pasteurianus GIM1.158 cells was successfully performed in a biphasic system consisting of deep eutectic solvent (DES) and water-immisc...
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Open AccessDiscovery and Optimization of N-Substituted 2-(4-pyridinyl)thiazole carboxamides against Tumor Growth through Regulating Angiogenesis Signaling Pathways
Inhibition of angiogenesis is considered as one of the desirable pathways for the treatment of tumor growth and metastasis. Herein we demonstrated that a series of pyridinyl-thiazolyl carboxamide derivatives w...
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Open AccessEvolutionary trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper
Snakes have numerous features distinctive from other tetrapods and a rich history of genome evolution that is still obscure. Here, we report the high-quality genome of the five-pacer viper, Deinagkistrodon acutus
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Open AccessRenal Denervation Improves the Baroreflex and GABA System in Chronic Kidney Disease-induced Hypertension
Hypertensive rats with chronic kidney disease (CKD) exhibit enhanced gamma-aminobutyric acid (GABA)B receptor function and regulation within the nucleus tractus solitarii (NTS). For CKD with hypertension, renal d...
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Open AccessThree dimensional printing of calcium sulfate and mesoporous bioactive glass scaffolds for improving bone regeneration in vitro and in vivo
In the clinic, bone defects resulting from infections, trauma, surgical resection and genetic malformations remain a significant challenge. In the field of bone tissue engineering, three-dimensional (3D) scaff...
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Open AccessCDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPP+-induced Parkinson’s disease model
Parkinson’s disease (PD) is an irreversible and progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta. Growing evidence indica...
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Open AccessAlleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression
Fluoxetine, one of the selective serotonin reuptake inhibitor (SSRI) antidepressants, has been thought to be effective for treating post-stroke depression (PSD). Recent work has shown that fluoxetine may exert...
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Open AccessChemopreventive effects of Ku-** tea against AOM-induced precancerous colorectal lesions in rats and metabolomic analysis
Ku-** tea (KJT) is a health beverage prepared from the leaves of the plant Acer tataricum subsp. ginnala that has been consumed in some regions of China for thousands of years. KJT contains high levels of anti-i...
