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  1. Article

    Open Access

    Therapeutic targeting miR130b counteracts diffuse large B-cell lymphoma progression via OX40/OX40L-mediated interaction with Th17 cells

    MicroRNAs (miRNAs) are involved in lymphoma progression by regulating the tumor microenvironment. Serum miR130b is overexpressed in diffuse large B-cell lymphoma (DLBCL), inducing Th17 cell alterations. To fur...

    Rui Sun, Pei-Pei Zhang, **ang-Qin Weng in Signal Transduction and Targeted Therapy (2022)

  2. Article

    Open Access

    Proteomic and phosphoproteomic profiling of COVID-19-associated lung and liver injury: a report based on rhesus macaques

    Jiang-Feng Liu, Ya-Nan Zhou, Shuai-Yao Lu in Signal Transduction and Targeted Therapy (2022)

  3. Article

    Open Access

    Safety and immunogenicity of a recombinant COVID-19 vaccine (Sf9 cells) in healthy population aged 18 years or older: two single-center, randomised, double-blind, placebo-controlled, phase 1 and phase 2 trials

    COVID-19 vaccines from multiple manufacturers are needed to cope with the problem of insufficient supply. We did two single-center, randomised, double-blind, placebo-controlled phase 1 and phase 2 trials to as...

    Fan-Yue Meng, Fan Gao, Si-Yue Jia in Signal Transduction and Targeted Therapy (2021)

  4. Article

    Open Access

    Dysregulation of the miR-148a–GLUT1 axis promotes the progression and chemoresistance of human intrahepatic cholangiocarcinoma

    Intrahepatic cholangiocarcinoma (iCCA) is a highly fatal malignant cancer worldwide. Elucidating the underlying molecular mechanism of iCCA progression is critical for the identification of new therapeutic tar...

    Pei Tiemin, **ao Peng, lang Qingfu, Wang Yan, Xue Junlin, He Zhefeng in Oncogenesis (2020)

  5. No Access

    Article

    Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate

    Monoamine oxidase A (MAOA) is a mitochondrial enzyme, which degrades monoamine neurotransmitters and dietary amines and produces H2O2. Recent studies have shown increased MAOA expression in prostate cancer (PCa),...

    Chun-Peng Liao, Tzu-** Lin, Pei-Chuan Li, Lauren A. Geary, Kevin Chen in Oncogene (2018)

  6. No Access

    Article

    Upregulation of the long noncoding RNA FOXD2-AS1 promotes carcinogenesis by epigenetically silencing EphB3 through EZH2 and LSD1, and predicts poor prognosis in gastric cancer

    Accumulating data indicate that long noncoding RNAs (lncRNAs) serve as important modulators in biological processes and are dysregulated in diverse tumors. The function of FOXD2-AS1 in gastric cancer (GC) progres...

    Tong-peng Xu, Wen-yu Wang, Pei Ma, You Shuai, Kun Zhao, Yan-fen Wang, Wei Li in Oncogene (2018)

  7. No Access

    Article

    Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance

    Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxyge...

    Wei Zhou, Wei Sun, Mingo M. H. Yung, Sheng Dai, Yihua Cai, Chi-Wei Chen in Oncogene (2018)