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    Article

    Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance

    Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxyge...

    Wei Zhou, Wei Sun, Mingo M. H. Yung, Sheng Dai, Yihua Cai, Chi-Wei Chen in Oncogene (2018)

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    Article

    Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate

    Monoamine oxidase A (MAOA) is a mitochondrial enzyme, which degrades monoamine neurotransmitters and dietary amines and produces H2O2. Recent studies have shown increased MAOA expression in prostate cancer (PCa),...

    Chun-Peng Liao, Tzu-** Lin, Pei-Chuan Li, Lauren A. Geary, Kevin Chen in Oncogene (2018)

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    Article

    Upregulation of the long noncoding RNA FOXD2-AS1 promotes carcinogenesis by epigenetically silencing EphB3 through EZH2 and LSD1, and predicts poor prognosis in gastric cancer

    Accumulating data indicate that long noncoding RNAs (lncRNAs) serve as important modulators in biological processes and are dysregulated in diverse tumors. The function of FOXD2-AS1 in gastric cancer (GC) progres...

    Tong-peng Xu, Wen-yu Wang, Pei Ma, You Shuai, Kun Zhao, Yan-fen Wang, Wei Li in Oncogene (2018)

  4. Article

    Open Access

    Dysregulation of the miR-148a–GLUT1 axis promotes the progression and chemoresistance of human intrahepatic cholangiocarcinoma

    Intrahepatic cholangiocarcinoma (iCCA) is a highly fatal malignant cancer worldwide. Elucidating the underlying molecular mechanism of iCCA progression is critical for the identification of new therapeutic tar...

    Pei Tiemin, **ao Peng, lang Qingfu, Wang Yan, Xue Junlin, He Zhefeng in Oncogenesis (2020)