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308 Result(s)
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Article
Interfacial energy-mediated bulk transport across artificial cell membranes
The construction of synthetic cells that exhibit some of the complex behaviors of biological cells is a fundamental challenge. A major bottleneck is the transport of substances across the artificial cell membr...
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Article
Characterization of the eXTP-LAD collimators
The enhanced X-ray Timing and Polarimetry mission (eXTP) is a next-generation flagship X-ray astronomy satellite currently in phase-B study. The large Area Detector (LAD) on board eXTP contains 40 modules, eac...
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Article
Open AccessIntermittent blood flow restriction with low-load resistance training for older adults with knee osteoarthritis: a randomized, controlled, non-inferiority trial protocol
Knee osteoarthritis (KOA) is a chronic musculoskeletal disorder characterized by pain and functional impairment. Blood flow restriction (BFR) with low-load resistance training (LLRT) demonstrates a similar imp...
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Article
Efficacy of chidamide maintenance therapy versus autologous stem cell transplantation versus observation as a post-remission choice in the survival of adult patients with peripheral T-cell lymphoma: Post hoc analysis of a prospective, multicenter, phase 2 study in China
In this prospective, multicenter, Phase 2 clinical trial (NCT02987244), patients with peripheral T-cell lymphomas (PTCLs) who had responded to first-line chemotherapy with cyclophosphamide, doxorubicin or epir...
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Article
Evolution and function of residual solvent in polymer-Li2B12H12 composite solid electrolyte
Composite solid electrolytes (CSEs) containing polymer matrices and inorganic fillers hold promise for the next generation of solid-state batteries. However, the role of residual solvents in CSEs remains contr...
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Article
Reduction of dinitrogen to ammonia on doped three-atom clusters Nb2M (M = Sc to Cu & Y to Ag)
Catalytic reduction of dinitrogen to ammonia under mild conditions remains an attractive topic for the purpose of lowering energy consumption. Three-atom metal clusters have been proved an ideal model to explo...
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Article
Discovery and pharmacological characterization of 1,2,3,4-tetrahydroquinoline derivatives as RORγ inverse agonists against prostate cancer
The retinoic acid receptor-related orphan receptor γ (RORγ) is regarded as an attractive therapeutic target for the treatment of prostate cancer. Herein, we report the identification, optimization, and evaluat...
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Article
Open AccessSRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors
The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor progression. However, the precise molecular mechanisms governing the nuclear import of YA...
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Article
Open AccessSUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1–involved EMT in hepatocellular carcinoma
The protein annexin A6 (AnxA6) is involved in numerous membrane-related biological processes including cell migration and invasion by interacting with other proteins. The dysfunction of AnxA6, including protei...
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Article
The effectiveness of various treatment approaches for laryngeal contact granulomas
To assess and compare the effectiveness of various treatment approaches for laryngeal contact granulomas (LCG).
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Article
Higher magnitude of sediment phosphorus release stimulated by ammonium than nitrate
Human activities have increased the amount of reactive inorganic nitrogen (RIN) in the biosphere. Recently, the effect of RIN on lake ecosystems (e.g., stress to aquatic organisms) has received increasing atte...
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Article
Fetal overgrowth and weight trajectories during infancy and adiposity in early childhood
Large-for-gestational age (LGA), a marker of fetal overgrowth, has been linked to obesity in adulthood. Little is known about how infancy growth trajectories affect adiposity in early childhood in LGA.
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Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial
Epigenetic modifications of chromatin, including histone acetylation, and tumor angiogenesis play pivotal roles in creating an immunosuppressive tumor microenvironment. In the randomized phase 2 CAPability-01 ...
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Article
Diagnosis, treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children: experts’ consensus statement updated for the Omicron variant
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Article
Open AccessEnsemble learning-assisted prediction of prolonged hospital length of stay after spine correction surgery: a multi-center cohort study
This research aimed to develop a machine learning model to predict the potential risk of prolonged length of stay in hospital before operation, which can be used to strengthen patient management.
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Article
Open AccessAge-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but the causes of SSPC senescence remain unclear. In this study, we revealed that macrophag...
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Article
Controlled ablation of impurity deposition in fusion devices by using variable laser fluence within depth-of-focus of focusing lens
The ability of laser pulse was tested for controlled ablation of the copper alloy (CuCrZr) and nanometer-thick impurity layer on the rear surface of a glass window. The target surface was moved across the focu...
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Article
Schizophrenia in the genetic era: a review from development history, clinical features and genomic research approaches to insights of susceptibility genes
Schizophrenia is a devastating neuropsychiatric disorder affecting 1% of the world population and ranks as one of the disorders providing the most severe burden for society. Schizophrenia etiology remains obsc...
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Article
Multifunctional ytterbium oxide buffer for perovskite solar cells
Perovskite solar cells (PSCs) comprise a solid perovskite absorber sandwiched between several layers of different charge-selective materials, ensuring unidirectional current flow and high voltage output of the...
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Article
Modeling Study of Divertor Pum** Effect on Detachment and Impurity Retention with Argon Seeding in EAST
The effects of divertor pum** on divertor detachment and core performance are investigated using SOLPS-ITER simulations for the H-mode discharges with argon (Ar) seeding on EAST. The simulation results show ...