21 Result(s)
within
**-li Lu
Neurology
Neurosciences
Psychiatry
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Article
Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture
Formation of neurofibrillary tangle from hyperphosphorylated tau is one of the hallmark lesions seen in Alzheimer’s disease (AD) brain, and neuronal deregulation of glycogen synthase kinase-3 (GSK-3) activity ...
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Article
Poster abstracts
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Article
Melatonin protects mice with intermittent hypoxia from oxidative stress-induced pancreatic injury
One of the most important mechanisms linking obstructive sleep apnea (OSA) to insulin resistance and type 2 diabetes involves oxidative stress. We examined whether oxidative stress-induced pancreatic injury co...
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Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation
Although the increased prevalence of Parkinson’s disease (PD) with aging suggests that aging processes predispose dopamine neurons to degeneration, the mechanism involved remains unknown. Dopamine neurons cont...
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An Event-Related Potential Study of Maternal Love in Mothers
Feeling is stable and implicit and can be explicated in concrete situations in the form of emotion. To map the time course of feeling processing, the present study explored electrophysiological responses relev...
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Association between interleukin-1α C(−889)T polymorphism and Alzheimer’s disease: a meta-analysis including 12,817 subjects
Epidemiological studies have evaluated the association between interleukin-1 (IL-1)α C(−889)T polymorphism and Alzheimer’s disease (AD), but the results remain inconclusive. This meta-analysis was, therefore, ...
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Open AccessBAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects
Attention-deficit/hyperactivity disorder (ADHD) is a common chronic neurodevelopmental disorder with a high heritability. Much evidence of hemisphere asymmetry has been found for ADHD probands from behavioral ...
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Open AccessAutism-associated gene Dlgap2 mutant mice demonstrate exacerbated aggressive behaviors and orbitofrontal cortex deficits
As elegant structures designed for neural communication, synapses are the building bricks of our mental functions. Recently, many studies have pointed out that synaptic protein-associated mutations may lead to...
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Association of three candidate genetic variants in RAB7L1/NUCKS1, MCCC1 and STK39 with sporadic Parkinson’s disease in Han Chinese
Previous studies identified that polymorphisms RAB7L1/NUCKS1 rs823118, MCCC1 rs12637471 and STK39 rs1955337 to be the risk loci for Parkinson’s disease (PD) in a Caucasian population. However, the characteristics...
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Article
Prevalence of small intestinal bacterial overgrowth in Chinese patients with Parkinson’s disease
Parkinson’s disease (PD) is associated with gastrointestinal motility abnormalities that could favor the occurrence of small intestinal bacterial overgrowth (SIBO). The aim of the study was to assess the preva...
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Article
Open AccessPrior Visual Experience Modulates Learning of Sound Localization Among Blind Individuals
Cross-modal learning requires the use of information from different sensory modalities. This study investigated how the prior visual experience of late blind individuals could modulate neural processes associa...
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Open AccessResveratrol ameliorates prenatal progestin exposure-induced autism-like behavior through ERβ activation
Recent literatures indicate that maternal hormone exposure is a risk factor for autism spectrum disorder (ASD). We hypothesize that prenatal progestin exposure may counteract the neuroprotective effect of estr...
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Open AccessInherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model
We previously performed targeted sequencing of autism risk genes in probands from the Autism Clinical and Genetic Resources in China (ACGC) (phase I). Here, we expand this analysis to a larger cohort of patien...
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Time Effects on Resting EEG in Children With/Without AD/HD
In this study we extend on behavioural evidence to examine the effect of time on EEG measures related to arousal and emotion/motivation in children with/without AD/HD. Thirty children with AD/HD and 30 age- an...
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Open AccessFunctional relationships between recessive inherited genes and genes with de novo variants in autism spectrum disorder
Both de novo variants and recessive inherited variants were associated with autism spectrum disorder (ASD). This study aimed to use exome data to prioritize recessive inherited genes (RIGs) with biallelically ...
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Article
Open AccessRisk factors for sleep disorders in patients undergoing peritoneal dialysis
Sleep disorders in patients with end-stage renal disease are common but have rarely been reported in previous studies. Therefore, we examined the prevalence of sleep disorders and the risk factors for declinin...
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Article
Evaluation of Brain Network Properties in Patients with MRI-Negative Temporal Lobe Epilepsy: An MEG Study
Abnormal functional brain networks of temporal lobe epilepsy (TLE) patients with structural abnormalities may partially reflect structural lesions rather than either TLE per se or functional compensatory proce...
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Article
Open AccessConvergent and divergent gray matter volume abnormalities in unaffected first-degree relatives and ultra-high risk individuals of schizophrenia
High-risk populations of schizophrenia can be mainly identified as genetic high-risk based on putative endophenotypes or ultra-high-risk (UHR) based on clinically manifested symptoms. Previous studies have con...
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Open AccessSpecific brain imaging alterations underlying autistic traits in children with attention-deficit/hyperactivity disorder
Autistic traits (ATs) are frequently reported in children with Attention-Deficit/Hyperactivity Disorder (ADHD). This study aimed to examine ATs in children with ADHD from both behavioral and neuroimaging persp...
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Open AccessInhibition of astroglial hemichannels ameliorates infrasonic noise induced short-term learning and memory impairment
As a kind of environmental noise, infrasonic noise has negative effects on various human organs. To date, research has shown that infrasound impairs cognitive function, especially the ability for learning and ...
