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  1. No Access

    Article

    A repertoire of intronic lariat RNAs reveals tissue-specific regulation and target mimicry potential in plants

    Lariat RNA is concomitantly produced by excised intron during RNA splicing, which is usually debranched by DBR1, an RNA debranching enzyme. However, increasing evidence showed that some lariat RNA could escape...

    Yong Zhang, **aotuo Zhang, Qi Tang, Lei Li, Ting Jiang… in Science China Life Sciences (2024)

  2. Article

    Open Access

    LncRNA SNHG26 promotes gastric cancer progression and metastasis by inducing c-Myc protein translation and an energy metabolism positive feedback loop

    Metastasis is a bottleneck in cancer treatment. Studies have shown the pivotal roles of long noncoding RNAs (lncRNAs) in regulating cancer metastasis; however, our understanding of lncRNAs in gastric cancer (G...

    Zhen-Hua Wu, Yi-Xuan Wang, Jun-Jiao Song, Li-Qin Zhao, Yu-Jia Zhai… in Cell Death & Disease (2024)

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  3. Article

    High-protein diet prevents fat mass increase after dieting by counteracting Lactobacillus-enhanced lipid absorption

    Dietary restriction is widely used to reduce fat mass and lose weight in individuals with or without obesity; however, weight regain after dieting is still a big challenge, and the underlying mechanisms remain...

    Wuling Zhong, Hui Wang, Yale Yang, Yali Zhang, He** Lai, Yalan Cheng… in Nature Metabolism (2022)

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  4. No Access

    Article

    Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells

    Glioblastoma (GBM) contains abundant tumor-associated macrophages (TAMs). The majority of TAMs are tumor-promoting macrophages (pTAMs), while tumor-suppressive macrophages (sTAMs) are the minority. Thus, repro...

    Kui Zhai, Zhi Huang, Qian Huang, Weiwei Tao, **aoguang Fang, Aili Zhang… in Nature Cancer (2021)

  5. No Access

    Article

    The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N6-methyladenosine methylation of Parp10 mRNA

    PIWI-interacting RNAs (piRNAs) are abundantly expressed during cardiac hypertrophy. However, their functions and molecular mechanisms remain unknown. Here, we identified a cardiac-hypertrophy-associated piRNA ...

    **ang-Qian Gao, Yu-Hui Zhang, Fang Liu, Murugavel Ponnusamy… in Nature Cell Biology (2020)

  6. No Access

    Article

    Proteomic profiling of HIV-1 infection of human CD4+ T cells identifies PSGL-1 as an HIV restriction factor

    Human immunodeficiency virus (HIV) actively modulates the protein stability of host cells to optimize viral replication. To systematically examine this modulation in HIV infection, we used isobaric tag-based m...

    Ying Liu, Ya**g Fu, Qian Wang, Mushan Li, Zheng Zhou… in Nature Microbiology (2019)