513 Result(s)
within
**-dong Wu
Life Sciences
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Article
Hotspot-based mutation engineering of MAase from Lactobacillus rhamnosus YXY412 for the improvement of hydrolytic activity
The semi-rational design of enzymes has become a popular and effective modification method to improve their hydrolytic activity and/or thermal stability toward target substrates. Here, the specific activity of...
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Open AccessRestoration of functional endometrium in an intrauterine adhesion rat model with endometrial stromal cells transplantation
Intrauterine adhesion (IUA) as a prevalent gynecological disease is developed from infection or trauma. However, therapeutic strategies to repair damaged endometrium are relatively limited. Emerging studies ha...
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Nondestructive estimation of specific macroelement contents in thalli of the red macroalga Pyropia yezoensis using hyperspectral imaging
In the economically important red macroalga Pyropia, carbohydrates and proteins contents are usually used to evaluate the nutritional status and commercial value. As main component elements of carbohydrates and p...
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Whole exome sequencing analyses reveal novel genes in telomere length and their biomedical implications
Telomere length is a putative biomarker of aging and is associated with multiple age-related diseases. There are limited data on the landscape of rare genetic variations in telomere length. Here, we systematic...
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Large-scale whole-exome sequencing of neuropsychiatric diseases and traits in 350,770 adults
While numerous genomic loci have been identified for neuropsychiatric conditions, the contribution of protein-coding variants has yet to be determined. Here we conducted a large-scale whole-exome-sequencing st...
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Evaluation of Monochromatic Excitation X-ray Fluorescence Spectrometry for Rapid Thallium Detection in Biological Samples Using Animal Models
Monochromatic excitation X-ray fluorescence (ME-XRF) spectrometry is a novel technique for trace element analysis, characterized by its simplicity, rapidity, and low cost. The objective of this study was to ev...
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Cytotoxic glutarimide-containing polyketides isolated from Streptomyces sp. JCM 4793
Glutarimide-containing polyketides usually exhibit anti-fungi activity, which was well exampled by cycloheximide. In our work, three new polyketide structures, 12-amidestreptimidone (1), 12-carboxylstreptimidone ...
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Open AccessTargeting ARNT attenuates chemoresistance through destabilizing p38α-MAPK signaling in glioblastoma
Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. This study aimed to investigate the functional significance of aryl hydrocarbon receptor nuclear translocator (ARNT) in the pathogene...
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Open AccessAgrin-Lrp4 pathway in hippocampal astrocytes restrains development of temporal lobe epilepsy through adenosine signaling
Human patients often experience an episode of serious seizure activity, such as status epilepticus (SE), prior to the onset of temporal lobe epilepsy (TLE), suggesting that SE can trigger the development of ep...
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Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes
The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across species. Enzymatic shuttles, particula...
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Open AccessFerroptosis: a potential bridge linking gut microbiota and chronic kidney disease
Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in lipid and iron metabolism, contribute to ferroptosis regu...
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Open AccessUnveiling the role of CaMKII in retinal degeneration: from biological mechanism to therapeutic strategies
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a family of broad substrate specificity serine (Ser)/threonine (Thr) protein kinases that play a crucial role in the Ca2+-dependent signaling pathways. Its ...
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Open AccessGTSE1 promotes nasopharyngeal carcinoma proliferation and angiogenesis by upregulating STMN1
Nasopharyngeal carcinoma (NPC) is a malignant tumor with poor survival rate. G2 and S phase-expressed‐1 (GTSE1) takes part in the progression of diverse tumors as an oncogene, but its role and potential mechan...
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Open AccessAnnotations of four high-quality indigenous chicken genomes identify more than one thousand missing genes in subtelomeric regions and micro-chromosomes with high G/C contents
Although multiple chicken genomes have been assembled and annotated, the numbers of protein-coding genes in chicken genomes and their variation among breeds are still uncertain due to the low quality of these ...
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Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy
The immune checkpoint TIGIT/PVR blockade exhibits significant antitumor effects through activation of NK and CD8+ T cell-mediated cytotoxicity. Immune checkpoint blockade (ICB) could induce tumor ferroptosis thro...
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Open AccessArtificial selection footprints in indigenous and commercial chicken genomes
Although many studies have been done to reveal artificial selection signatures in commercial and indigenous chickens, a limited number of genes have been linked to specific traits. To identify more trait-relat...
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Open AccessInsights into chloroplast genome evolution in Rutaceae through population genomics
Chloroplast genomes, pivotal for understanding plant evolution, remain unexplored in Rutaceae, a family with key perennial crops like citrus. Leveraging next-generation sequencing data from 509 Rutaceae access...
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Litter quality controls the earthworm microbiome in crop** fields
Agriculture is using litter inputs (such as straw) as an alternative to inorganic fertilization; however, little is known about how these inputs can alter the microbiome of our soils. Earthworms are major ecos...
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Effects of LED Light Quality on Broccoli Microgreens Plant Growth and Nutrient Accumulation
Broccoli microgreens represent a novel type of vegetable characterized by high levels of bioactive compounds. Here, we investigated the effects of light-emitting diode (LED) light quality on the development an...
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Open AccessNextDenovo: an efficient error correction and accurate assembly tool for noisy long reads
Long-read sequencing data, particularly those derived from the Oxford Nanopore sequencing platform, tend to exhibit high error rates. Here, we present NextDenovo, an efficient error correction and assembly too...
