410 Result(s)

Article

A novel gene delivery system targeting cells expressing VEGF receptors

Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or pro...

Jun Min LI, Jun Song HAN, Yi HUANG, Pei Kun TIAN, Shu Min QU, Min YAO… in Cell Research (1999)

Article

RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling

Many marketed therapeutic agents have been developed to modulate the function of G protein-coupled receptors (GPCRs). The regulators of G-protein signaling (RGS proteins) are also being examined as potential d...

Yu-Ching Fang, Wei-Hsin Sun, Li-Cheng Wu, Hsien-Da Huang, Hsueh-Fen Juan… in BMC Genomics (2006)

Article

Detection of the inferred interaction network in hepatocellular carcinoma from EHCO (E ncyclopedia of H epatocellular C arcinoma genes O nline)

The significant advances in microarray and proteomics analyses have resulted in an exponential increase in potential new targets and have promised to shed light on the identification of disease markers and cel...

Chun-Nan Hsu, **-Mei Lai, Chia-Hung Liu, Huei-Hun Tseng… in BMC Bioinformatics (2007)

Article

Comparative analysis of differentially expressed genes in normal and white spot syndrome virus infected Penaeus monodon

White spot syndrome (WSS) is a viral disease that affects most of the commercially important shrimps and causes serious economic losses to the shrimp farming industry worldwide. However, little information is ...

Jiann-Horng Leu, Chih-Chin Chang, **-Lu Wu, Chun-Wei Hsu, Ikuo Hirono… in BMC Genomics (2007)

Article

Glycogen synthase kinase 3α and 3β have distinct functions during cardiogenesis of zebrafish embryo

Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine protein kinase, is known to play roles in many biological processes. Two closely related GSK3 isoforms encoded by distinct genes: GSK3α (51 kDa) and...

Huang-Chieh Lee, Jen-Ning Tsai, Pei-Yin Liao, Wei-Yuan Tsai… in BMC Developmental Biology (2007)

Article

Protein structural similarity search by Ramachandran codes

Protein structural data has increased exponentially, such that fast and accurate tools are necessary to access structure similarity search. To improve the search speed, several methods have been designed to re...

Wei-Cheng Lo, Po-Jung Huang, Chih-Hung Chang, **-Chiang Lyu in BMC Bioinformatics (2007)

Article

A rice phenomics study—phenotype scoring and seed propagation of a T-DNA insertion-induced rice mutant population

With the completion of the rice genome sequencing project, the next major challenge is the large-scale determination of gene function. As an important crop and a model organism, rice provides major insights in...

Chyr-Guan Chern, Ming-Jen Fan, Su-May Yu, Ai-Ling Hour… in Plant Molecular Biology (2007)

Article

Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction

Ganoderma lucidum has been widely used as a herbal medicine for promoting health and longevity in China and other Asian countries. Polysaccharide extracts from Ganoderma lucidum have been reported to exhibit immu...

Kun-Chieh Cheng, Hsuan-Cheng Huang, Jenn-Han Chen, Jia-Wei Hsu… in BMC Genomics (2007)

Article

Construction and characterization of an expressed sequenced tag library for the mosquito vector Armigeres subalbatus

The mosquito, Armigeres subalbatus, mounts a distinctively robust innate immune response when infected with the nematode Brugia malayi, a causative agent of lymphatic filariasis. In order to mine the transcriptom...

George F Mayhew, Lyric C Bartholomay, Hang-Yen Kou, Thomas A Rocheleau… in BMC Genomics (2007)

Chapter and Conference Paper

A Theory Model for Description of the Electrical Signals in Plant Part I

The ion mechanism for membrane potential of higher plant was discussed in this paper. A modified Hodgkin and Huxley model was developed for description of the electrical signals in plant. Three individual comp...

Zhongyi Wang, Lan Huang, **aofei Yan… in Computer And Computing Technologies In Agr… (2008)

Article

MeInfoText: associated gene methylation and cancer information from text mining

DNA methylation is an important epigenetic modification of the genome. Abnormal DNA methylation may result in silencing of tumor suppressor genes and is common in a variety of human cancer cells. As more epige...

Yu-Ching Fang, Hsuan-Cheng Huang, Hsueh-Fen Juan in BMC Bioinformatics (2008)

Article

Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis

Because the gene expression patterns of nonobese hepatic steatosis in affected patients remain unclear, we sought to explore these patterns using an animal model of nonobese hepatic steatosis.

Ming-Ling Chang, Chau-Ting Yeh, Jeng-Chang Chen, Chau-Chun Huang… in BMC Genomics (2008)

Article

Histamine metabolism influences blood vessel branching in zebrafish reg6mutants

Vascular branching morphogenesis is responsible for the extension of blood vessels into growing tissues, a process crucial for organogenesis. However, the genetic mechanism for vessel branching is largely unkn...

Cheng-chen Huang, Chin-Wei Huang, Yih-Shyun E Cheng, John Yu in BMC Developmental Biology (2008)

Article

Postnatal stem/progenitor cells derived from the dental pulp of adult chimpanzee

Chimpanzee dental pulp stem/stromal cells (ChDPSCs) are very similar to human bone marrow derived mesenchymal stem/stromal cells (hBMSCs) as demonstrated by the expression pattern of cell surface markers and t...

Pei-Hsun Cheng, Brooke Snyder, Dimitri Fillos, Chris C Ibegbu… in BMC Cell Biology (2008)

Article

The UDP-glucosyltransferase multigene family in Bombyx mori

Glucosidation plays a major role in the inactivation and excretion of a great variety of both endogenous and exogenous compounds. A class of UDP-glycosyltransferases (UGTs) is involved in this process. Insect ...

Fei-Fei Huang, Chun-Li Chai, Ze Zhang, Zeng-Hu Liu, Fang-Yin Dai, Cheng Lu… in BMC Genomics (2008)

Article

Antibody-fused interferons as an effective approach to enhance target specificity and antiviral efficacy of type I interferons

Lucy S Cheng, Seungmin Hwang, Tzu-Hsuan Huang, Ting-Chang Sheu, Ren Sun… in Cell Research (2008)

Article

Duck (Anas platyrhynchos) linkage map** by AFLP fingerprinting

Amplified fragment length polymorphism (AFLP) with multicolored fluorescent molecular markers was used to analyze duck (Anas platyrhynchos) genomic DNA and to construct the first AFLP genetic linkage map. These m...

Chang-Wen Huang, Yu-Shin Cheng, Roger Rouvier, Kuo-Tai Yang… in Genetics Selection Evolution (2009)

Article

Eleven generations of selection for the duration of fertility in the intergeneric crossbreeding of ducks

A 12-generation selection experiment involving a selected line (S) and a control line (C) has been conducted since 1992 with the aim of increasing the number of fertile eggs laid by the Brown Tsaiya duck after...

Yu-Shin Cheng, Roger Rouvier, Hsiao-Lung Liu… in Genetics Selection Evolution (2009)

Article

POINeT: protein interactome with sub-network analysis and hub prioritization

Protein-protein interactions (PPIs) are critical to every aspect of biological processes. Expansion of all PPIs from a set of given queries often results in a complex PPI network lacking spatiotemporal conside...

Sheng-An Lee, Chen-Hsiung Chan, Tzu-Chi Chen, Chia-Ying Yang… in BMC Bioinformatics (2009)

Article

An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules

The TGF-β/SMAD pathway is part of a broader signaling network in which crosstalk between pathways occurs. While the molecular mechanisms of TGF-β/SMAD signaling pathway have been studied in detail, the global ...

Huaxia Qin, Michael WY Chan, Sandya Liyanarachchi, Curtis Balch… in BMC Systems Biology (2009)