125 Result(s)
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Article
Open AccessWalkable Dual Emissions
Walkable dual emissions, in which the emission bands of the walker reversibly cross or leave those of the stationary ones depending on temperature and concentration, have been demonstrated in cyclic dimeric la...
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Open AccessCadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site
The heavy metal cadmium is a non-degradable pollutant. By screening the effects of a panel of metal ions on the phosphatase activity, we unexpectedly identified cadmium as a potent inhibitor of PPM1A and PPM1G...
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Open AccessAkt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency
Although PTEN/Akt signaling is frequently deregulated in human gastric cancers, the in vivo causal link between its dysregulation and gastric tumorigenesis has not been established. Here we show that inactivation...
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Open AccessA Promising New Class of High-Temperature Alloys: Eutectic High-Entropy Alloys
High-entropy alloys (HEAs) can have either high strength or high ductility and a simultaneous achievement of both still constitutes a tough challenge. The inferior castability and compositional segregation of ...
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Open AccessRegulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection
T cell functional exhaustion during chronic hepatitis B virus (HBV) infection may contribute to the failed viral clearance; however, the underlying molecular mechanisms remain largely unknown. Here we demonstr...
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Open AccessCassava genome from a wild ancestor to cultivated varieties
Cassava is a major tropical food crop in the Euphorbiaceae family that has high carbohydrate production potential and adaptability to diverse environments. Here we present the draft genome sequences of a wild ...
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Open AccessComparative characterization of two intracellular Ca2+-release channels from the red flour beetle, Tribolium castaneum
Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are members of a family of tetrameric intracellular Ca2+-release channels (CRCs). While it is well known in mammals that RyRs and IP3R...
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Open AccessThe complex jujube genome provides insights into fruit tree biology
The jujube (Ziziphus jujuba Mill.), a member of family Rhamnaceae, is a major dry fruit and a traditional herbal medicine for more than one billion people. Here we present a high-quality sequence for the complex ...
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Open AccessReversible switching of magnetic states by electric fields in nitrogenized-divacancies graphene decorated by tungsten atoms
Magnetic graphene-based materials have shown great potential for develo** high-performance electronic devices at sub-nanometer such as spintronic data storage units. However, a significant reduction of power...
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Article
Open AccessPrevalence and genetic characteristics of Saffold cardiovirus in China from 2009 to 2012
The epidemiology and clinical features of the Saffold cardiovirus (SAFV) remain ambiguous. The present study was designed to systematically and intensively investigate the epidemiological features of SAFV in p...
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Open AccessSurface Enhanced Electrochemiluminescence of Ru(bpy)32+
Surface enhanced spectroscopy such as surface enhanced Raman spectrum (SERS) and surface enhanced fluorescence have been investigated extensively in the past two decades. Herein, we present experimental eviden...
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Article
Correction: Corrigendum: Reversible switching of magnetic states by electric fields in nitrogenized-divacancies graphene decorated by tungsten atoms
Using molecular dynamics simulations, we investigated an integrated bio-nano interface consisting of a β-sheet protein stacked onto graphene. We found that the stacking assembly of the model protein on graphen...
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Article
Open AccessCancer risk among patients with type 2 diabetes mellitus: a population-based prospective study in China
Evidence indicates an increased cancer risk among type 2 diabetes mellitus (T2DM) patients, yet studies in mainland China are scarce. Based on Diabetes Surveillance System linking to Cancer Surveillance System...
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Open AccessCharacterization of Three Tetrabromobisphenol-S Derivatives in Mollusks from Chinese Bohai Sea: A Strategy for Novel Brominated Contaminants Identification
Identification of novel brominated contaminants in the environment, especially the derivatives and byproducts of brominated flame retardants (BFRs), has become a wide concern because of their adverse effects o...
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Open AccessIdentification of Alp1U and Lom6 as epoxy hydrolases and implications for kinamycin and lomaiviticin biosynthesis
The naturally occurring diazobenzofluorenes, kinamycins, fluostatins and lomaiviticins, possess highly oxygenated A-rings, via which the last forms a dimeric pharmacophore. However, neither the A-ring transfor...
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Article
Open AccessRegulation of T cell function by microRNA-720
Chronic hepatitis B virus (HBV) infection is a major global health burden. Functional exhaustion and numerical reduction of HBV-specific cytotoxic T lymphocytes (CTLs) in the liver and peripheral blood limit a...
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Open AccessIdentification of Bufavirus-1 and Bufavirus-3 in Feces of Patients with Acute Diarrhea, China
Bufavirus (BuV) is a newly discovered human parvovirus that has been detected in some countries. The current study was designed to understand the epidemic of BuV in China. Totally 1877 fecal specimens were col...
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Open AccessThe effect of exogenous calcium on mitochondria, respiratory metabolism enzymes and ion transport in cucumber roots under hypoxia
Hypoxia induces plant stress, particularly in cucumber plants under hydroponic culture. In plants, calcium is involved in stress signal transmission and growth. The ultimate goal of this study was to shed ligh...
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Open AccessCUG-BP1 regulates RyR1 ASI alternative splicing in skeletal muscle atrophy
RNA binding protein is identified as an important mediator of aberrant alternative splicing in muscle atrophy. The altered splicing of calcium channels, such as ryanodine receptors (RyRs), plays an important r...
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Open AccessLovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties
Lovastatin is a member of Statins, which are beneficial in a lot of immunologic cardiovascular diseases and T cell-mediated autoimmune diseases. Kv1.3 channel plays important roles in the activation and prolif...
