220 Result(s)
within
**-bin Guo
Life Sciences
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Article
Open AccessGenome-wide analysis of MYB transcription factor family and AsMYB1R subfamily contribution to ROS homeostasis regulation in Avena sativa under PEG-induced drought stress
The myeloblastosis (MYB) transcription factor (TF) family is one of the largest and most important TF families in plants, playing an important role in a life cycle and abiotic stress.
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Open AccessGenome sequence of Fusarium oxysporum strain ByF01, the causal agent of root rot of Knoxia roxburghii in China
Knoxia roxburghii is a member of the madder (Rubiaceae) family. This plant is cultivated in different areas of China and recognized for its medicinal properties, which leads to its use in traditional Chinese medi...
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Open AccessHAX-1 interferes in assembly of NLRP3-ASC to block microglial pyroptosis in cerebral I/R injury
Acute cerebral ischemia has a high rate of disability and death. Although timely recanalization therapy may rescue the ischemic brain tissue, cerebral ischemia-reperfusion injury has been shown to limit the th...
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Metagenomic analysis of individual mosquito viromes reveals the geographical patterns and drivers of viral diversity
Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a ...
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Effects of parental nutritional programming on the hatching parameters, metabolome, glucose metabolism-related gene expressions, and global DNA methylation in larvae of yellow catfish Tachysurus fulvidraco
Nutritional programming has the potential to enhance digestible carbohydrate utilization in fish; however, the underlying mechanisms remain unclear. The present study compared the metabolome, glucose metabolis...
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Open AccessAberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
The prostate is a vital accessory gonad in the mammalian male reproductive system. With the ever-increasing proportion of the population over 60 years of age worldwide, the incidence of prostate diseases, such...
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Open AccessGenome-wide analysis of the KNOX gene family in Moso bamboo: insights into their role in promoting the rapid shoot growth
KNOTTED1-like homeobox (KNOX) genes, plant-specific homologous box transcription factors (TFs), play a central role in regulating plant growth, development, organ formation, and response to biotic and abiotic str...
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Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose
Previous studies have implicated targeting Pim-1 proto-oncogene, serine/threonine kinase (PIM1) as a preventive measure against high glucose–induced cellular stress and apoptosis. This study aimed to reveal th...
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Metabolism, antioxidant and immunity in acute and chronic hypoxic stress and the improving effect of vitamin C in the channel catfish (Ictalurus punctatus)
Hypoxia is the most significant factor that threatens the health and even survival of freshwater and marine fish. Priority should be given to the investigation of hypoxia adaptation mechanisms and their subseq...
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Interactive effects of dietary leucine and isoleucine affect amino acid profile and metabolism through AKT/TOR signaling pathways in blunt snout bream (Megalobrama amblycephala)
The purpose of this research is to explore the interaction between dietary leucine and isoleucine levels on whole-body composition, plasma and liver biochemical indexes, amino acids deposition in the liver, an...
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Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation
DNA cytosine methylation plays a vital role in repressing retrotransposons, and such derepression is linked with developmental failure, tumorigenesis and aging. DNA methylation patterns are formed by precisely...
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Vector-mediated viral exchange between crops and weedy plants
While virus-vector-crop interactions have received considerable attention, free-living plants growing in cultivated areas (‘weeds’) can also serve as viral reservoirs. Although weed-to-crop transmission is wel...
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Open AccessscInterpreter: a knowledge-regularized generative model for interpretably integrating scRNA-seq data
The rapid emergence of single-cell RNA-seq (scRNA-seq) data presents remarkable opportunities for broad investigations through integration analyses. However, most integration models are black boxes that lack i...
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High-fat diet alters intestinal microbiota and induces endoplasmic reticulum stress via the activation of apoptosis and inflammation in blunt snout bream
The primary organ for absorbing dietary fat is the gut. High dietary lipid intake negatively affects health and absorption by causing fat deposition in the intestine. This research explores the effect of a hig...
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Open AccessFerroptosis sensitization in glioma: exploring the regulatory mechanism of SOAT1 and its therapeutic implications
Glioma, the most common primary malignant tumor of the central nervous system, lacks effective targeted therapies. This study investigates the role of SOAT1, a key gene involved in cholesterol esterification, ...
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Article
PARylated PDHE1α generates acetyl-CoA for local chromatin acetylation and DNA damage repair
Chromatin relaxation is a prerequisite for the DNA repair machinery to access double-strand breaks (DSBs). Local histones around the DSBs then undergo prompt changes in acetylation status, but how the large de...
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Open AccessLow glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in co...
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Open AccessATGL deficiency aggravates pressure overload-triggered myocardial hypertrophic remodeling associated with the proteasome-PTEN-mTOR-autophagy pathway
Persistent myocardial hypertrophy frequently leads to heart failure (HF). Intramyocardial triacylglycerol (TAG) accumulation is closely related with cardiac remodeling and abnormal contractile function. Adipos...
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Open AccessEffect of using reclaimed water via furrow and subsurface drip systems under alternate partial root-zone irrigation mechanism on crops growth and soil properties
The growing population in the face of water scarcity inevitably necessitates the quest for alternative sources of irrigation water, which integrates them with irrigation strategies for improved agricultural pr...
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Lin28a maintains a subset of adult muscle stem cells in an embryonic-like state
During homeostasis and after injury, adult muscle stem cells (MuSCs) activate to mediate muscle regeneration. However, much remains unclear regarding the heterogeneous capacity of MuSCs for self-renewal and re...
