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Chapter
Die Dampflokomotive
Betrachtet man den Bahnbau als den Anfang einer Eisenbahngeschichte, so ist die in Betrieb genommene Eisenbahnstrecke eine Schaubühne verschiedener Typen von Lokomotiven. Nicht nur in England, dem Ursprungslan...
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Chapter
Überblick über die Chinesischen Eisenbahnen
Der Drache wurde als ein übernatürliches Wesen in der Sage von der chinesischen Nation verehrt. Man sah in ihm den höchsten Gott, weil der Drache launisch und unabschätzbar sei, Wind und Regen herbeizaubern, d...
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Article
The DNA sequence, annotation and analysis of human chromosome 3
After the completion of a draft human genome sequence1, the International Human Genome Sequencing Consortium has proceeded to finish2 and annotate each of the 24 chromosomes comprising the human genome. Here we d...
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Article
Quantum teleportation and entanglement distribution over 100-kilometre free-space channels
Quantum teleportation of independent qubits and entanglement distribution have been demonstrated over free-space channels of about 100 kilometres, representing an important step towards a global quantum network.
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Article
Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin
Chronic inflammation is a feature of the ageing brain and some neurodegenerative diseases; the authors show that astrocytes normally suppress neuroinflammation through activation of their DRD2 receptor by CRYA...
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Article
Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne
Severe acne is a chronic inflammatory skin disorder characterized by widespread inflammatory lesions including nodules, cysts and potential scarring. Here we perform the first genome-wide association study of ...
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Article
Open AccessKainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation
Surface expression and regulated endocytosis of glycine receptors (GlyRs) play a critical function in balancing neuronal excitability. SUMOylation (SUMO modification) is of critical importance for maintaining ...
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Article
Open AccessRoom temperature synthesis of cobalt-manganese-nickel oxalates micropolyhedrons for high-performance flexible electrochemical energy storage device
Cobalt-manganese-nickel oxalates micropolyhedrons were successfully fabricated by a room temperature chemical co-precipitation method. Interestingly, the Co0.5Mn0.4Ni0.1C2O4*nH2O micropolyhedrons and graphene nan...
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Article
Open AccessDiscrete Li-occupation versus pseudo-continuous Na-occupation and their relationship with structural change behaviors in Fe2(MoO4)3
The key factors governing the single-phase or multi-phase structural change behaviors during the intercalation/deintercalation of guest ions have not been well studied and understood yet. Through systematic st...
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Article
Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations
Age-related macular degeneration (AMD) is a leading cause of irreversible central blindness among the elderly worldwide. We use exome sequencing to analyse nonsynonymous single-nucleotide variants (SNVs) acros...
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Article
Open AccessRice ragged stunt virus-induced apoptosis affects virus transmission from its insect vector, the brown planthopper to the rice plant
Most plant viruses that seriously damage agricultural crops are transmitted by insects. However, the mechanisms enabling virus transmission by insect vectors are poorly understood. The brown planthopper (Nilaparv...
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Article
Open AccessDynamic transcriptome analysis and volatile profiling of Gossypium hirsutum in response to the cotton bollworm Helicoverpa armigera
In response to insect herbivory, plants emit elevated levels of volatile organic compounds for direct and indirect resistance. However, little is known about the molecular and genomic basis of defense response...
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Article
Open AccessIdentification of Estrogen Response Element in Aquaporin-3 Gene that Mediates Estrogen-induced Cell Migration and Invasion in Estrogen Receptor-positive Breast Cancer
Accumulating evidence suggests that aquaporins (AQPs) may facilitate tumor development. The molecular pathways connecting the pathological functions of AQPs are unclear and need to be better defined. This stud...
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Article
Open AccessLycorine suppresses RANKL-induced osteoclastogenesis in vitro and prevents ovariectomy-induced osteoporosis and titanium particle-induced osteolysis in vivo
Osteoclasts play an important role in diseases involving bone loss. In this study, we assessed the effect of a plant-derived natural alkaloid (lycorine, or LY) on osteoclastogenesis in vitro and in vivo. Our in v...
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Article
Open AccessQuantum Spin Hall States in Stanene/Ge(111)
For topological insulators to be implemented in practical applications, it is a prerequisite to select suitable substrates that are required to leave insulators’ nontrivial properties and sizable opened band g...
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Article
Open AccessDown-regulation of microRNA-144 in air pollution-related lung cancer
Air pollution has been classified as a group 1 carcinogen in humans, but the underlying tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung cancer incidence is among the highes...
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Article
Open AccessRadiobiological modeling analysis of the optimal fraction scheme in patients with peripheral non-small cell lung cancer undergoing stereotactic body radiotherapy
This study aimed to determine the optimal fraction scheme (FS) in patients with small peripheral non-small cell lung cancer (NSCLC) undergoing stereotactic body radiotherapy (SBRT) with the 4 × 12 Gy scheme as...
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Article
Open AccessSignatures of the Adler–Bell–Jackiw chiral anomaly in a Weyl fermion semimetal
Weyl semimetals provide the realization of Weyl fermions in solid-state physics. Among all the physical phenomena that are enabled by Weyl semimetals, the chiral anomaly is the most unusual one. Here, we repor...
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Article
Open AccessThe plasma miR-125a, miR-361 and miR-133a are promising novel biomarkers for Late-Onset Hypogonadism
Circulating miRNAs have been shown to serve as diagnostic/prognostic biomarkers in cancers and other diseases. However, the role of plasma miRNAs in Late-onset hypogonadism (LOH) diagnosis is still unknown. Us...
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Article
Open AccessRegnase-1 in microglia negatively regulates high mobility group box 1-mediated inflammation and neuronal injury
Extracellular high mobility group box 1 (HMGB1) has been demonstrated to function as a proinflammatory cytokine and induces neuronal injury in response to various pathological stimuli in central nervous system...