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  1. No Access

    Article

    Enhancer reprogramming driven by high-order assemblies of transcription factors promotes phenotypic plasticity and breast cancer endocrine resistance

    Acquired therapy resistance is a major problem for anticancer treatment, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model, we show that endocrine resist...

    Mingjun Bi, Zhao Zhang, Yi-Zhou Jiang, Pengya Xue, Hu Wang, Zhao Lai… in Nature Cell Biology (2020)

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    Chapter

    Functional Proteomics Screening for Novel Anti-viral Drug Targets

    Viruses reside in the living cells and interact with a variety of host factors. Traditionally, scientists are focused on targeting virus-specific processes or enzymes with specific drugs to eliminate the patho...

    Shengtao Zhou, Manchao Kuang, **a Zhao… in New Advances on Disease Biomarkers and Mol… (2013)

  3. No Access

    Article

    Advanced glycation end-products induce heparanase expression in endothelial cells by the receptor for advanced glycation end products and through activation of the FOXO4 transcription factor

    As an endo-β (1-4)-d-glucuronidase, heparanase can specifically cleave carbohydrate chains of heparan sulfate (HS) and has been implicated in development of endothelial cells dsyfunction. The advanced glycation e...

    **ao-Fei An, Lei Zhou, Peng-Jun Jiang, Ming Yan… in Molecular and Cellular Biochemistry (2011)