11 Result(s)
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Article
Application of Pseudo Amino Acid Composition for Predicting Protein Subcellular Location: Stochastic Signal Processing Approach
The function of a protein is closely correlated with its subcellular location. With the success of human genome project and the rapid increase in the number of newly found protein sequences entering into data ...
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Article
An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for β-amyloid peptide as a monomer
Aβ1–42 is the proteolytic cleavage product of cleavage of the amyloid precursor protein by β- and γ-secretases. The aggregation of Aβ1–42 plays a causative role in the development of Alzheimer’s disease. To lock ...
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Article
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells
The diperpenoid adenanthin covalently modifies the resolving cysteine from peroxiredoxins to inhibit the reduction of hydrogen peroxide, a second messenger in cells, and thereby activates pathways that promote...
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Article
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway
TR3 is an orphan nuclear receptor with roles in apoptosis. A TR3-binding compound induces mitochondrial translocation of TR3 and autophagy via the Nix–Toms–ANT1/VDAC1 pathway, providing a mechanism for cell de...
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Article
The Structure and Enzyme Characteristics of a Recombinant Leucine Aminopeptidase rLap1 from Aspergillus sojae and Its Application in Debittering
A leucine aminopeptidase Lap1 was cloned from Aspergillus sojae GIM3.30. The truncated Lap1 without a signal peptide was over-expressed in P. pastoris, and the enzymatic characteristics of recombinant Lap1 (rLap1...
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Article
Fluorescent labeling for clonal selection of Marc 145 cells secreting high levels of recombinant protein PBD-1
Despite the powerful impact gene expression markers like the green fluorescent protein (GFP) or enhanced GFP (EGFP) exert on linking the expression of recombinant protein for selection of high producers in rec...
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Article
Process optimization for the rapid production of Enterovirus 71
Enterovirus 71 (EV71) infection can cause hand–foot-and-mouth disease (HFMD). Inactivated EV71 vaccine was effective to prevent EV71 derived HFMD. A highly efficient and economical process for producing EV71 i...
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Article
Design, synthesis, and insecticidal/acaricidal evaluation of novel pyrimidinamine derivatives containing phenyloxazole moiety
A series of novel pyrimidinamine derivatives containing phenyloxazole moiety were designed and synthesized, and their structures were characterized by 1H NMR, MS, and elemental analyses. The bioassay results disp...
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Article
Develo** GDi-CRISPR System for Multi-copy Integration in Saccharomyces cerevisiae
In recent years, Saccharomyces cerevisiae has been widely used in the production of biofuels and value-added chemicals. To stably express the target products, it is necessary to integrate multiple target genes in...
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Article
Migration and agglomeration of chlorine in dechlorination of coal-fired flue gas
Dechlorination of coal-fired flue gas is a novel approach for realizing zero discharge of desulfurization wastewater. The core principle is to convert the HCl in the flue gas into chloride salt, which will mig...
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Article
miR-1246-overexpressing exosomes suppress UVB-induced photoaging via regulation of TGF-β/Smad and attenuation of MAPK/AP-1 pathway
Stem cell therapy is widely employed for the treatment of skin diseases, especially in skin rejuvenation. Exosomes derived from stem cells have been demonstrated to possess anti-photoaging effects; however, th...
