25 Result(s)
within
**-Sup Shin
Biomedicine, general
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Article
Open AccessA nationwide study of breast reconstruction after mastectomy in patients with breast cancer receiving postmastectomy radiotherapy: comparison of complications according to radiotherapy fractionation and reconstruction procedures
We examined the patterns of breast reconstruction postmastectomy in breast cancer patients undergoing postmastectomy radiotherapy (PMRT) and compared complications based on radiotherapy fractionation and recon...
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Open AccessAuthor Correction: Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure
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Article
Open AccessAge-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure
Skeletal muscle aging results in the gradual suppression of myogenesis, leading to muscle mass loss. However, the specific role of cardiolipin in myogenesis has not been determined. This study investigated the...
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Article
Open AccessProtocol for the postoperative radiotherapy in N1 breast cancer patients (PORT-N1) trial, a prospective multicenter, randomized, controlled, non-inferiority trial of patients receiving breast-conserving surgery or mastectomy
Postoperative radiotherapy (PORT) could be useful for pN1 breast cancer patients who have undergone breast-conserving surgery (BCS) or mastectomy. However, the value of regional nodal irradiation (RNI) for BCS...
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Article
Altruism and social rewards
Scheggia et al.1 have established a behavioral paradigm to explore preferences for ‘altruistic’ or ‘selfish’ choice behavior in mice. The results suggest that altruistic behavior develops through reinforcement le...
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Regeneration of infarcted mouse hearts by cardiovascular tissue formed via the direct reprogramming of mouse fibroblasts
Fibroblasts can be directly reprogrammed into cardiomyocytes, endothelial cells or smooth muscle cells. Here we report the reprogramming of mouse tail-tip fibroblasts simultaneously into cells resembling these...
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Article
25C-NBF, a new psychoactive substance, has addictive and neurotoxic potential in rodents
The use of new psychoactive substances (NPSs) as a substitute for illegal drugs is increasing rapidly and is a serious threat to public health. 25C-NBF is a newly synthesized phenethylamine-type NPS that acts ...
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Open AccessAspirin for metal stent in malignant distal common bile duct obstruction (AIMS): study protocol for a multicenter randomized controlled trial
Endoscopic retrograde biliary drainage (ERBD) is the treatment of choice for patients with malignant distal common bile duct (CBD) obstruction. Self-expandable metal stents (SEMS), which are commonly used in u...
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Open AccessLymph node ratio as valuable predictor in pancreatic cancer treated with R0 resection and adjuvant treatment
Lymph-node (LN) metastasis is an important prognostic factor in resected pancreatic cancer. In this study, the prognostic value of American Joint Committee on Cancer (AJCC) 8th edition N stage, lymph-node rati...
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Article
Significant enhancement of photoresponsive characteristics and mobility of MoS2-based transistors through hybridization with perovskite CsPbBr3 quantum dots
Inorganic perovskite CsPbBr3 quantum dots (QDs) are potential nanoscale photosensitizers; moreover, two-dimensional (2-D) molybdenum disulfide (MoS2) has been intensively studied for application in the active lay...
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Article
Open AccessANO9/TMEM16J promotes tumourigenesis via EGFR and is a novel therapeutic target for pancreatic cancer
Anoctamin (ANO)/transmembrane member 16 (TMEM16) proteins mediate diverse physiological and pathophysiological functions including cancer cell proliferation. The present study aimed to identify the role of ANO...
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Article
Optogenetic control of endogenous Ca2+ channels in vivo
A single-component optogenetic tool controls calcium fluxes with high dynamic range.
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Article
Bidirectional modulation of fear extinction by mediodorsal thalamic firing in mice
The mediodorsal thalamus links the medial prefrontal cortex and the amygdala in associative learning process in primates. Using mouse models, this study finds that the dual firing modes of mediodorsal thalamus...
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Article
GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice
ADHD is characterized by hyperactivity and deficits in learning and memory. Now, Eunjoon Kim and colleagues report that a polymorphism in the gene that encodes the adaptor protein GIT1 is linked to ADHD in hum...
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Article
A cyclophilin A CPR1 overexpression enhances stress acquisition in Saccharomyces cerevisiae
Cyclophilins are conserved cis-trans peptidyl-prolyl isomerase that are implicated in protein folding and function as molecular chaperones. We found the expression of cyclophilin A, Cpr1, changes in response to e...
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Article
Oligometastases confined one organ from colorectal cancer treated by SBRT
To determine the feasibility and efficacy of stereotactic body radiotherapy (SBRT) for oligometastases from colorectal cancer (CRC). Total of 59 patients with 78 lesions confined to one organ and treated from ...
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Article
Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
Primates can develop a conditioned fear response by witnessing other primates being subjected to adverse stimuli. Jeon et al. report that mice are capable of this form of observational fear conditioning and that ...
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Article
Expression of a glutathione reductase from Brassica rapa subsp. pekinensis enhanced cellular redox homeostasis by modulating antioxidant proteins in Escherichia coli
Glutathione reductase (GR) is an enzyme that recycles a key cellular antioxidant molecule glutathione (GSH) from its oxidized form (GSSG) thus maintaining cellular redox homeostasis. A recombinant plasmid to o...
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Article
Neuroprotective effects of roasted licorice, not raw form, on neuronal injury in gerbil hippocampus after transient forebrain ischemia
To observe neuroprotective effects of raw and roasted licorice against hypoxia and ischemic damage.
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Article
Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR–PLCβ4 signaling
Phospholipase C β4 (PLCβ4) is expressed in the suprachiasmatic nucleus (SCN), as well as in tissues in the circadian entrainment pathway, including the retina and the lateral geniculate nucleus in the mouse1,2. U...
