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Article
Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice
Diabetes mellitus (DM), an important public health problem, aggravates the global economic burden. Diabetic encephalopathy (DE) is a serious complication of DM in the central nervous system. Metformin has been...
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Article
Numerical and laboratory experiments on the toppling behavior of a massive single block: a case study of the Furnas Reservoir, Brazil
A massive toppling failure occurred at the edge of the Furnas Reservoir at 12:30 (UTC-03) on 8 January 2022, in Brazil. The toppling belongs to single-block toppling with a volume of about 3.32 × 102 m3 and cause...
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Article
A critical review of operating stability issues in electrochemical CO2 reduction
Electrocatalytic carbon dioxide reduction reaction (CO2RR) offers a promising solution for mitigating environmental challenges by converting CO2 into value-added chemicals and fuels. However, the long-term stabil...
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Article
The effect of secondary phase on corrosion behaviors of the titanium–zirconium–molybdenum alloy
As the range of applications for molybdenum and its alloys has expanded, the corrosive environment for molybdenum alloys has become more demanding. In the past, the content of do** elements has been studied ...
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Article
Enhancement of comprehensive properties of Nb–Si based in-situ composites by Ho rare earth do**
This study examines the microstructure, mechanical properties (with a focus on room-temperature toughness), and oxidation resistance of Ho-doped Nb–Si based in-situ composites. The base alloy consists of the c...
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Article
Formation and growth of nanophase iron particles on the surface of Mercury revealed by experimental study
Space weathering is a primary factor in altering the composition and spectral characteristics of surface materials on airless planets. However, current research on space weathering focuses mainly on the Moon a...
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Article
Investigation of the Inhibitory Effects of Illicium verum Essential Oil Nanoemulsion on Fusarium proliferatum via Combined Transcriptomics and Metabolomics Analysis
Fusarium proliferatum is the main pathogen that causes Panax notoginseng root rot. The shortcomings of strong volatility and poor water solubility of Illicium verum essential oil (EO) limit its utilization. In th...
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Article
Cation-Dipole Interaction-Induced Coacervate Underwater Adhesives in Natural Seawater
Significant progress has been made in wet adhesives for low salinity water, but exploration of general ionic adhesives for natural seawater is less developed because the high salinity could weaken interfacial ...
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Article
Open AccessComparative analysis of GoPro and digital cameras in head and neck flap harvesting surgery video documentation: an innovative and efficient method for surgical education
An urgent need exists for innovative surgical video recording techniques in head and neck reconstructive surgeries, particularly in low- and middle-income countries where a surge in surgical procedures necessi...
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Article
Open AccessInitiating PeriCBD to probe perinatal influences on neurodevelopment during 3–10 years in China
Adverse perinatal factors can interfere with the normal development of the brain, potentially resulting in long-term effects on the comprehensive development of children. Presently, the understanding of cognit...
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Article
Numerical Simulation of the Mass Movement Process of the 2018 Sedongpu Glacial Debris Flow by Using the Fluid-Solid Coupling Method
In the context of global warming and intensified human activities, glacier instability in plateau regions has increased, and glacier debris flows have become active, which poses a significant threat to the liv...
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Article
Treatment and survival for patients with localized primary ocular adnexal extranodal marginal zone lymphoma
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Article
Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n
Nondestructive and noninvasive neutron assays are essential applications of neutron techniques. Neutron resonance transmission analysis (NRTA) is a powerful nondestructive method for investigating the elementa...
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Article
Advances in bio-inspired electrocatalysts for clean energy future
Electrocatalysis can enable efficient energy storage and conversion and thus is an effective way to achieve carbon neutrality. The unique structure and function of organisms can offer many ideas for the design...
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Article
The Community of Arbuscular Mycorrhizal Fungi in Sugarcane Rhizosphere Soils in Guangxi, China
In order to analyze the community of the arbuscular mycorrhizal fungi (AMF) in the rhizosphere soil and roots of sugarcane in Guangxi, China, this study analyzed the 18S rDNA gene sequences, soil physicochemic...
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Article
Open AccessTP53 to mediate immune escape in tumor microenvironment: an overview of the research progress
Increasing evidence suggests that key cancer-causing driver genes continue to exert a sustained influence on the tumor microenvironment (TME), highlighting the importance of immunotherapeutic targeting of gene...
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Chapter and Conference Paper
Systematic Evaluation of the Efficacy and Safety of Rivastigmine in Combination with Memantine for Mild to Moderate Alzheimer’s Disease Based on MCMC Algorithm
Objective: To systematically analyze the efficacy and safety of rivastigmine combined with memantine in the treatment of mild to moderate Alzheimer’s disease. Methods: In this paper we searched the Chinese and En...
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Article
The synthesis and secretion of key substances in the flavonoid metabolic pathway responding to different nitrogen sources during early growth stages in Robinia pseudoacacia
Legumes can obtain nitrogen from mineral nitrogen and symbiotic nitrogen; however, the regulatory mechanisms by which legume plants respond to various nitrogen sources are still unclear.
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Article
Large DNA fragment knock-in and sequential gene editing in Plasmodium falciparum: a preliminary study using suicide-rescue-based CRISPR/Cas9 system
CRISPR/Cas9 technology applied to Plasmodium falciparum offers the potential to greatly improve gene editing, but such expectations including large DNA fragment knock-ins and sequential gene editing have remained...
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Article
Open AccessCharacteristics of blood immune cell profile and their correlation with disease progression in patients infected with HIV-1
Antiretroviral therapy (ART) can reduce viral load in individuals infected with human immunodeficiency virus (HIV); however, some HIV-infected individuals still cannot achieve optimal immune recovery even afte...
