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Article
Elucidating the Influence Mechanism of Vanadium Addition on Dendritic Structure and Precipitated Phase of 30Cr15Mo1N Ingot During Pressurized Solidification
By analyzing element segregation and dendritic growth kinetics in combination with microstructure observation and thermodynamic calculation, the influence mechanism of vanadium addition on the dendritic struct...
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Article
Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
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Article
Open AccessOLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway
Intestinal metaplasia (IM) is classified into complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (IIM). Patients diagnosed with IIM face an elevated susceptibility to the development of ...
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Article
Image-defined risk factors associated with MYCN oncogene amplification in neuroblastoma and their association with overall survival
The MYCN oncogene is a critical factor in the development and progression of neuroblastoma, and image-defined risk factors (IDRFs) are radiological findings used for the preoperative staging of neuroblastoma. Thi...
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Article
MiR-135a-5p regulates window of implantation by suppressing pinopodes development and decidualization of endometrial stromal cells
The window of implantation (WOI) is a brief period during which the endometrium is receptive to embryo implantation. This study investigated the relationship between miR-135a-5p and endometrial receptivity.
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Article
Hydrophobic and anti-fouling polyelectrolyte complex coating for durable flame-retardant cotton fabric
Surface treatment is one of the most effective ways to impart flame retardancy to fabrics, woods, etc. Especially, water-soluble polyelectrolyte complex (PEC) coating deposition is one of the most environmenta...
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Article
Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
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Article
Open AccessAgrin-Lrp4 pathway in hippocampal astrocytes restrains development of temporal lobe epilepsy through adenosine signaling
Human patients often experience an episode of serious seizure activity, such as status epilepticus (SE), prior to the onset of temporal lobe epilepsy (TLE), suggesting that SE can trigger the development of ep...
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Article
Substance P in the medial amygdala regulates aggressive behaviors in male mice
Behavioral and clinical studies have revealed a critical role of substance P (SP) in aggression; however, the neural circuit mechanisms underlying SP and aggression remain elusive. Here, we show that tachykini...
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Article
Open AccessLipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis
Oxidative stress-induced lipid accumulation is mediated by lipid droplets (LDs) homeostasis, which sequester vulnerable unsaturated triglycerides into LDs to prevent further peroxidation. Here we identify the ...
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Article
Genomic data and ecological niche modeling reveal an unusually slow rate of molecular evolution in the Cretaceous Eupteleaceae
Living fossils are evidence of long-term sustained ecological success. However, whether living fossils have little molecular changes remains poorly known, particularly in plants. Here, we have introduced a nov...
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Article
Cardioprotective Potential of Cymbopogon citratus Essential Oil against Isoproterenol-induced Cardiomyocyte Hypertrophy: Possible Involvement of NLRP3 Inflammasome and Oxidative Phosphorylation Complex Subunits
Cymbopogon citratus (DC.) Stapf is a medicinal and edible herb that is widely used for the treatment of gastric, nervous and hypertensive disorders. In this study, we investigated the cardioprotective effects and...
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Article
Open AccessPerioperative complication incidence and risk factors for retroperitoneal neuroblastoma in children: analysis of 571 patients
Surgery plays an important role in the treatment of neuroblastoma. Perioperative complications may impact the course of neuroblastoma treatment. To date, comprehensive analyses of complications and risk factor...
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Article
CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets
Stroke, the second-largest cause of death and the leading cause of disability globally, presents significant challenges in terms of prognosis and treatment. Identifying reliable prognosis biomarkers and treatm...
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Article
Open AccessA novel alternative for pyrogen detection based on a transgenic cell line
Pyrogen, often as a contaminant, is a key indicator affecting the safety of almost all parenteral drugs (including biologicals, chemicals, traditional Chinese medicines and medical devices). It has become a go...
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Article
Open AccessPhylogeny and diversification of genus Sanicula L. (Apiaceae): novel insights from plastid phylogenomic analyses
The genus Sanicula L. is a unique perennial herb that holds important medicinal values. Although the previous studies on Sanicula provided us with a good research basis, its taxonomic system and interspecific rel...
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Article
Open AccessSurplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy
Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear. Here, we show that surplus fatty a...
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Article
Open AccessMap** nucleosome-resolution chromatin organization and enhancer-promoter loops in plants using Micro-C-XL
Although chromatin organizations in plants have been dissected at the scales of compartments and topologically associating domain (TAD)-like domains, there remains a gap in resolving fine-scale structures. Her...
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Article
Efficacy and Mechanism Study of 6S-5-Methyltetrahydrofolate-Calcium Against Telencephalon Infarction Injury in Zebrafish Model of Ischemic Stroke
Ischemic stroke is a heterogeneous brain injury with complex pathophysiology and it is also a time sensitive neurological injury disease. At present, the treatment options for ischemic stroke are still limited...
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Article
A Class of Prescribed Weingarten Curvature Equations for Locally Convex Hypersurfaces with Boundary in \(\mathbb {R}^{n+1}\)
In this paper, we consider a class of prescribed Weingarten curvature equations for strictly locally convex hypersurfaces with boundary in $$\...
