-
Article
Rab11b promotes M1-like macrophage polarization by restraining autophagic degradation of NLRP3 in alcohol-associated liver disease
Macrophage polarization is vital to mounting a host defense or repairing tissue in various liver diseases. Excessive activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is related to th...
-
Article
Open AccessPEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3
The peroxisome is a versatile organelle that performs diverse metabolic functions. PEX3, a critical regulator of the peroxisome, participates in various biological processes associated with the peroxisome. Whe...
-
Article
Open AccessDevelo** an entrustable professional activity for providing health education and consultation in occupational therapy and examining its validity
Entrustable Professional Activities (EPA)-based assessment is easily and intuitively used in evaluating the learning outcomes of competency-based medical education (CBME). This study aimed to develop an EPA fo...
-
Article
Open AccessNovel radiopaque ethanol injection: physicochemical properties, animal experiments, and clinical application in vascular malformations
Despite the efficacy of absolute ethanol (EtOH), its radiolucency introduces several risks in interventional therapy for treating vascular malformations. This study aims to develop a novel radiopaque ethanol i...
-
Article
Open AccessUsing a DNA mini-barcode within the ITS region to identify toxic Amanita in mushroom poisoning cases
Mushroom poisoning contributes significantly to global foodborne diseases and related fatalities. Amanita mushrooms frequently cause such poisonings; however, identifying these toxic species is challenging due to...
-
Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
-
Article
T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin
T cell engaging bispecific antibodies (TCBs) have recently become significant in cancer treatment. In this study we developed MSLN490, a novel TCB designed to target mesothelin (MSLN), a glycosylphosphatidylin...
-
Article
Hepatic and Extrahepatic Characteristics of Autoimmune Hepatitis: A 23-year Hospital-Based Cohort Study
The characteristics of autoimmune hepatitis (AIH) in Asia mostly remain elusive.
-
Article
Open AccessClinical significance and prospective mechanism of increased CDKN2A expression in small cell lung cancer
Although it has been shown that cyclin dependent kinase inhibitor 2A (CDKN2A) plays a significant role in a number of malignancies, its clinicopathological value and function in small cell lung cancer (SCLC) i...
-
Article
Open AccessTwo-dimensional materials for future information technology: status and prospects
Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...
-
Article
Desloratadine ameliorates paclitaxel-induced peripheral neuropathy and hypersensitivity reactions in mice
Paclitaxel (PTX) serves as a primary chemotherapy agent against diverse solid tumors including breast cancer, lung cancer, head and neck cancer and ovarian cancer, having severe adverse effects including PTX-i...
-
Article
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway
Cardiac fibrosis is a detrimental pathological process, which constitutes the key factor for adverse cardiac structural remodeling leading to heart failure and other critical conditions. Circular RNAs (circRNA...
-
Article
Open AccessSustainable upcycling of mixed spent cathodes to a high-voltage polyanionic cathode material
Sustainable battery recycling is essential for achieving resource conservation and alleviating environmental issues. Many open/closed-loop strategies for critical metal recycling or direct recovery aim at a si...
-
Article
Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE/IGF-1/Akt, TGF-β/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice
Type 2 diabetes mellitus (T2DM) is a metabolic disease. Diabetes increases the risk of benign prostatic hyperplasia (BPH). Capsaicin is extracted from chili peppers and possesses many pharmacological propertie...
-
Article
Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress
To investigate the pharmacological mechanism of Qili Qiangxin Capsule (QLQX) improvement of heart failure (HF) based on miR133a-endoplasmic reticulum stress (ERS) pathway.
-
Article
Gas microchannel plate-pixel detector for X-ray polarimetry
POLAR-2 is a gamma-ray burst (GRB) polarimeter that is designed to study the polarization in GRB radiation emissions, aiming to improve our knowledge of related mechanisms. POLAR-2 is expected to utilize an on...
-
Article
Open AccessRotational magnetoelectric switching in orthorhombic multiferroics
Controlling the direction of ferromagnetism and antiferromagnetism by an electric field in single-phase multiferroics will open the door to the next generation of devices for spintronics and electronics. The t...
-
Article
Retraction Note: Sonochemical Synthesis of Two New Nanostructured La(III) Coordination Polymers: Inducing Tongue Cancer Cell Apoptosis and ROS Accumulation by Targeting FHIT
-
Article
Electronic-scale assessment of high-temperature oxidation mechanisms in a novel Fe-based alloy
The development of alloys with high antioxidation performance is limited by the ambiguous details of the oxidation mechanism. Here, based on the structures of internal oxides detected by high-resolution transm...
-
Article
Multiscale control of MnO2 growth via [WO6]-perturbed [MnO6] assembly toward a favorable balance between capacitance and rate performance
Although pseudocapacitive manganese dioxide (MnO2) integrates the high-power merit of carbonaceous materials with the high-energy merit of battery-type materials, it still has a long way to go in achieving a more...
