491 Result(s)
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Article
Open AccessExploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resi...
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Article
Reaction Mechanism of Actin ATP Hydrolysis Studied by QM/MM Calculations
Actin fibers are an important part of the cytoskeleton, providing vital support for the plasma membrane. This function is driven by its ATPase (ATP: adenosine triphosphate) activity, i.e., ATP+H2O→ADP+Pi. This se...
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Integrative Analysis of the Microbiome and Metabolome of Broiler Intestine: Insights into the Mechanisms of Probiotic Action as an Antibiotic Substitute
Antibiotic substitutes have become a research focus due to restrictions on antibiotic usage. Among the antibiotic substitutes on the market, probiotics have been extensively researched and used. However, the m...
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Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities
With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple discip...
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A review of heterocyclic aromatic amines in cooked meat: generation pathways and mitigation mechanism by natural exogenous additives
Heterocyclic aromatic amines (HAAs) are a class of carcinogenic substances formed during thermal processing of meat foods. Natural exogenous additives have been widely used in the food processing industry due ...
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Efficient synthesis of bottle-brush polymers enabled by selective photoactivation strategy in NIR-induced PET-RAFT polymerization
Bottle-brush polymers possessing densely grafted side chains have special properties that are distinct from linear macromolecules. Herein, an efficient method for preparing bottle-brush polymers based on a sel...
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Open AccessStudy on automatic lithology identification based on convolutional neural network and deep transfer learning
Automatic and fast rock classification identification is an important part of geotechnical intelligent survey system. Image based supervised deep learning analysis, especially for convolutional neural networks...
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Article
Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling
Recent advances in chemical proteomics have focused on develo** chemical probes that react with nucleophilic amino acid residues. Although histidine is an attractive candidate due to its importance in enzyma...
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LATS2 condensates organize signalosomes for Hippo pathway signal transduction
Biomolecular condensates have been proposed to mediate cellular signaling transduction. However, the mechanism and functional consequences of signal condensates are not well understood. Here we report that LAT...
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Article
Copper-based catalysts for carbon monoxide electroreduction to multicarbon products
Electrochemical carbon dioxide reduction (ECO2R) is an attractive pathway to store carbon and renewable energy as chemical bonds in multi-carbon products. However, the complex multi-step reaction processes set hu...
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Article
Uncovering Potentially Therapeutic Phytochemicals, In silico Analysis, and Biological Assessment of South-Chinese Red Dragon Fruit (Hylocereus polyrhizus)
Red dragon fruit is gaining popularity globally due to its nutritional value and bioactive components. The study aimed to assess the phytochemical, nutritional composition, antioxidant, antibacterial, and cyto...
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Open AccessA divergent intermediate strategy yields biologically diverse pseudo-natural products
The efficient exploration of biologically relevant chemical space is essential for the discovery of bioactive compounds. A molecular design principle that possesses both biological relevance and structural div...
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Partitioning of pore space in hydrogen-bonded organic frameworks for enhanced CO2 photoreduction
Hydrogen-bonded organic frameworks (HOFs) hold significant promise for catalytic applications. However, the collapse of pores upon solvent removal significantly restricts the utility of HOFs in photocatalytic ...
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Article
Effects of endogenous anthocyanins from purple corn on the quality, physicochemical properties and antioxidant capacity of bread
Purple corn is nutritious and contains biologically active ingredients such as anthocyanins and dietary fiber. As a natural green food raw material, it has great potential for development. The existing anthocy...
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Article
Selective and Rapid Detection of Minocycline in Milk Using a Novel Fluorescence Conjugated Polymer Probe
Minocycline is a broad-spectrum antibiotic widely used in clinical and veterinary medicine and its adverse effects are as prominent as its potent efficacy. To avoid its abuse and accumulation, it is very impor...
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Article
Tetraphenylethene-based hole transporting material for highly efficient and stable perovskite solar cells
2,2,7,7-Tetrakis-(N,N-di-p-methoxyphenylamine)-9,9-spirobifluorene (Spiro-OMeTAD) has been identified as the most widely used and effective hole transporting material (HTM) in perovskite solar cells (PSCs). Howev...
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Article
Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA
Fluorescent RNAs (FRs) provide an attractive approach to visualizing RNAs in live cells. Although the color palette of FRs has been greatly expanded recently, a green FR with high cellular brightness and photo...
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Open AccessMultifunctional nanorobot system in precise evaluation and manipulation of virus capsid
It is imperative to have high adaptive techniques for sensing and manipulating biological targets at the nanoscale. This necessity becomes particularly crucial when dealing with fragile living bio-organisms li...
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Article
Different Detection Strategies of Pediocin-Like Produced by Pediococcus pentosaceus
In this study, Pediococcus pentosaceus C-2–1 and C23221 contained genes encoding penocin and pediocin PA-1, mined by antiSMASH. The penocin structural gene pedA from Pediococcus pentosaceus C-2–1 was successfully...
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Synthetic tuning stabilizes a high-valence Ru single site for efficient electrolysis
Water electrolysis powered by renewable electricity can produce clean hydrogen, but the technology is limited by the slow anodic oxygen evolution reaction (OER). The most active monometallic OER catalyst is hi...
