516 Result(s)
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Open AccessIdentification, validation and candidate gene analysis of major QTL for Supernumerary spikelets in wheat
The number of spikelets per spike is a key trait that affects the yield of bread wheat (Triticum aestivum L.). Identification of the QTL for spikelets per spike and its genetic effects that could be used in molec...
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Open AccessUnderstanding the genetic complexity of puberty timing across the allele frequency spectrum
Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, th...
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Open AccessThe elite haplotype OsGATA8-H coordinates nitrogen uptake and productive tiller formation in rice
Excessive nitrogen promotes the formation of nonproductive tillers in rice, which decreases nitrogen use efficiency (NUE). Develo** high-NUE rice cultivars through balancing nitrogen uptake and the formation...
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SLC10A1 rs2296651 variant (S267F mutation) predicts biochemical traits, hepatitis B virus infection susceptibility and the risk of gallstone disease
Sodium taurocholate co-transporting polypeptide (NTCP), a bile acid transporter, plays a crucial role in regulating bile acid levels and influencing the risk of HBV infection. Genetic variations in the SLC10A1 ge...
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Open AccessAn improved genome assembly of Chrysanthemum nankingense reveals expansion and functional diversification of terpene synthase gene family
Terpenes are important components of plant aromas, and terpene synthases (TPSs) are the key enzymes driving terpene diversification. In this study, we characterized the volatile terpenes in five different Chrysan...
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A single-cell transcriptome atlas of human euploid and aneuploid blastocysts
Aneuploidy is frequently detected in early human embryos as a major cause of early pregnancy failure. However, how aneuploidy affects cellular function remains elusive. Here, we profiled the transcriptomes of ...
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Genome folding principles uncovered in condensin-depleted mitotic chromosomes
During mitosis, condensin activity is thought to interfere with interphase chromatin structures. To investigate genome folding principles in the absence of chromatin loop extrusion, we codepleted condensin I a...
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Open AccessGenomic analyses reveal the stepwise domestication and genetic mechanism of curd biogenesis in cauliflower
Cauliflower (Brassica oleracea L. var. botrytis) is a distinctive vegetable that supplies a nutrient-rich edible inflorescence meristem for the human diet. However, the genomic bases of its selective breeding hav...
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Long noncoding RNAs underlie multiple domestication traits and leafhopper resistance in soybean
The origin and functionality of long noncoding RNA (lncRNA) remain poorly understood. Here, we show that multiple quantitative trait loci modulating distinct domestication traits in soybeans are pleiotropic ef...
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Open AccessHiFi long-read amplicon sequencing for full-spectrum variants of human mtDNA
Mitochondrial diseases (MDs) can be caused by single nucleotide variants (SNVs) and structural variants (SVs) in the mitochondrial genome (mtDNA). Presently, identifying deletions in small to medium-sized frag...
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Open AccessGenome assembly of Ottelia alismoides, a multiple-carbon utilisation aquatic plant
Ottelia Pers. is in the Hydrocharitaceae family. Species in the genus are aquatic, and China is their centre of origin in Asia. Ottelia alismoides (L.) Pers., which is distributed wor...
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Open AccessSingle-cell 3D genome structure reveals distinct human pluripotent states
Pluripotent states of embryonic stem cells (ESCs) with distinct transcriptional profiles affect ESC differentiative capacity and therapeutic potential. Although single-cell RNA sequencing has revealed addition...
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Open AccessMap** and functional characterization of structural variation in 1060 pig genomes
Structural variations (SVs) have significant impacts on complex phenotypes by rearranging large amounts of DNA sequence.
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A spatiotemporal atlas of cholestatic injury and repair in mice
Cholestatic liver injuries, characterized by regional damage around the bile ductular region, lack curative therapies and cause considerable mortality. Here we generated a high-definition spatiotemporal atlas ...
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Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics
Large-scale imaging of neuronal activities is crucial for understanding brain functions. However, it is challenging to analyze large-scale imaging data in real time, preventing closed-loop investigation of neu...
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Open AccessCrosstalk of disulfidptosis-related subtypes identifying a prognostic signature to improve prognosis and immunotherapy responses of clear cell renal cell carcinoma patients
Disulfidptosis is a novel form of programmed cell death induced by high SLC7A11 expression under glucose starvation conditions, unlike other known forms of cell death. However, the roles of disulfidptosis in c...
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Open AccessRBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5
Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms of their involvement in transcriptional proces...
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Open AccessHaplotype-resolved genome of Mimosa bimucronata revealed insights into leaf movement and nitrogen fixation
Mimosa bimucronata originates from tropical America and exhibits distinctive leaf movement characterized by a relative slow speed. Additionally, this species possesses the ability to fix nitrogen. Despite these i...
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Primer extension refractory PCR: an efficient and reliable genome walking method
Genome walking, a molecular technique for obtaining unknown flanking genomic sequences from a known genomic sequence, has been broadly applied to determine transgenic sites, mine new genetic resources, and fil...
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Open AccessDraft genome of Brasenia schreberi, a worldwide distributed and endangered aquatic plant
Brasenia is a monotypic genus in the family of Cabombaceae. The only species, B. schreberi, is a macrophyte distributed worldwide. Because it requires good water quality, it is endangered in China and other count...
