-
Article
Open AccessMycobacterium tuberculosis produces d-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Adaptation to hypoxia is a major challenge for the survival of Mycobacterium tuberculosis (Mtb) in vivo. Interferon (IFN)-γ-producing CD8+ T cells contribute to control of Mtb infection, in part by promoting anti...
-
Article
Open AccessThe levels of women’s awareness, experience, acceptability and preference for Vaginal Human Papillomavirus (HPV) self-sampling in three provinces of China: a cross-sectional study
The primary screening technique for precancerous lesions and cervical cancer is human papillomavirus (HPV) testing, and HPV self-sampling has been shown to be consistent with clinician sampling in terms of the...
-
Article
Electrochemically recycling degraded superalloy and valorizing CO2 in the affordable borate-modified molten electrolyte
Integrating electrochemical reduction of CO2 and electrochemical oxidation to recycle degraded superalloys is a promising solution to ease resource scarcity and safeguard environmental sustainability. Herein, we ...
-
Article
Open AccessHMG-CoA reductase is a potential therapeutic target for migraine: a mendelian randomization study
Statins are thought to have positive effects on migraine but existing data are inconclusive. We aimed to evaluate the causal effect of such drugs on migraines using Mendelian randomization. We used four types ...
-
Article
Open AccessSignal enhancement ratio of multi-phase contrast-enhanced MRI: an imaging biomarker for survival in pancreatic adenocarcinoma
To evaluate signal enhancement ratio (SER) for tissue characterization and prognosis stratification in pancreatic adenocarcinoma (PDAC), with quantitative histopathological analysis (QHA) as the reference stan...
-
Article
Mitochondrial genomes of Tapes dorsatus and Cardita variegata: insights into Heteroconchia phylogeny
Heteroconchia, a widespread and abundant aquatic invertebrate, is an important clade of bivalve mollusks. The relationship between the three branches of Heteroconchia, Palaeoheterodonta, Archiheterodonta, and ...
-
Article
Open AccessNeuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood.
-
Article
Open AccessFine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...
-
Article
Open AccessDiabetes and osteoporosis: a two-sample mendelian randomization study
The effects on bone mineral density (BMD)/fracture between type 1 (T1D) and type 2 (T2D) diabetes are unknown. Therefore, we aimed to investigate the causal relationship between the two types of diabetes and B...
-
Article
Open AccessDB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors
HER3 (ErbB3), a member of the human epidermal growth factor receptor family, is frequently overexpressed in various cancers. Multiple HER3-targeting antibodies and antibody–drug conjugates (ADCs) were develope...
-
Article
Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats
Osteoarthritis (OA) is a degenerative joint disorder characterized by the gradual degradation of joint cartilage and local inflammation. This study aimed to investigate the anti-OA effect of scutellarein (SCU)...
-
Article
Open AccessCorrection: c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory responses
-
Article
Open AccessExploring the therapeutic potential of isoorientin in the treatment of osteoporosis: a study using network pharmacology and experimental validation
Isoorientin (ISO) is a glycosylated flavonoid with antitumor, anti-inflammatory, and antioxidant properties. However, its effects on bone metabolism remain largely unknown.
-
Article
Milestone progress of the HEPS booster commissioning
The high-energy photon source (HEPS) is the first fourth-generation synchrotron light source facility in China. The HEPS injector consists of a linear accelerator (Linac) and a full energy booster. The booster...
-
Article
Open AccessMiscarriage risk assessment: a bioinformatic approach to identifying candidate lethal genes and variants
Miscarriage, often resulting from a variety of genetic factors, is a common pregnancy outcome. Preconception genetic carrier screening (PGCS) identifies at-risk partners for newborn genetic disorders; however,...
-
Article
Observation of plaid-like spin splitting in a noncoplanar antiferromagnet
Spatial, momentum and energy separation of electronic spins in condensed-matter systems guides the development of new devices in which spin-polarized current is generated and manipulated1–3. Recent attention on a...
-
Article
Robotic-assisted organ-preserving or parenchymal-sparing pancreatectomy in pancreatic benign or low-grade malignant tumors: a single institute’s experience
Robotic-assisted pancreatectomy has been widely used. Organ-preserving pancreatectomy (OPP) and parenchymal-sparing pancreatectomy (PSP) has been gradually adopted for pancreatic benign or low-grade malignant ...
-
Chapter and Conference Paper
Analysis of Gas Well Production Capacity Control Factors and Evaluation of Favorable Development Areas in the Maokou Formation in Central Sichuan
Since 2020, significant breakthroughs has been made in the exploration of the Permian Maokou Formation in central Sichuan, which has become an important field for increasing conventional gas reserves and produ...
-
Chapter and Conference Paper
The Characterization of Fan Delta Front Based on the Human–Machine Interactive Measurement and Flume Experiment
Fan delta, as an important sedimentary type at the margin of basin, is an important place for the enrichment of petroleum, natural gas and other geological resources. Limited by static data obtained from reser...
-
Chapter and Conference Paper
Experimental Evaluation of the Succession Sequence During Commingled Production in a Tight Gas Reservoir
With the continuing development of tight multilayer reservoirs, commingled production technology has been widely adopted for multilayer tight gas reservoirs and coalbed methane co-production. This paper assemb...
