245 Result(s)
-
Article
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
Treatment of infected patients with ABT-538, an inhibitor of the protease of human immuno-deficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 ±0.4 days) ...
-
Article
The DNA sequence and comparative analysis of human chromosome 10
The finished sequence of human chromosome 10 comprises a total of 131,666,441 base pairs. It represents 99.4% of the euchromatic DNA and includes one megabase of heterochromatic sequence within the pericentrom...
-
Article
The DNA sequence of the human X chromosome
The human X chromosome has a unique biology that was shaped by its evolution as the sex chromosome shared by males and females. We have determined 99.3% of the euchromatic sequence of the X chromosome. Our ana...
-
Article
Open AccessGenome sequencing in microfabricated high-density picolitre reactors
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with...
-
Article
CRTC3 links catecholamine signalling to energy balance
The adipose-derived hormone leptin maintains energy balance in part through central nervous system-mediated increases in sympathetic outflow that enhance fat burning. Triggering of β-adrenergic receptors in ad...
-
Article
Concurrent transition of ferroelectric and magnetic ordering near room temperature
Strong spin-lattice coupling in condensed matter gives rise to intriguing physical phenomena such as colossal magnetoresistance and giant magnetoelectric effects. The phenomenological hallmark of such a strong...
-
Article
Open AccessRepeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres
The Gossypium genus is used to investigate emergent consequences of polyploidy in cotton species; comparative genomic analyses reveal a complex evolutionary history including interactions among subgenomes that re...
-
Article
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) regulates anabolic b...
-
Article
Open AccessDraft genome sequence of the mulberry tree Morus notabilis
Human utilization of the mulberry–silkworm interaction started at least 5,000 years ago and greatly influenced world history through the Silk Road. Complementing the silkworm genome sequence, here we describe ...
-
Article
Chitosan confinement enhances hydrogen photogeneration from a mimic of the diiron subsite of [FeFe]-hydrogenase
Nature has created [FeFe]-hydrogenase enzyme as a hydrogen-forming catalyst with a high turnover rate. However, it does not meet the demands of economically usable catalytic agents because of its limited stabi...
-
Article
Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon
There are no antivirals or vaccines available to treat Enterovirus 71 (EV71) infections. Although the type I interferon response, elicited upon virus infection, is critical to establishing host antiviral innat...
-
Article
Open AccessSynergistic delivery of gold nanorods using multifunctional microbubbles for enhanced plasmonic photothermal therapy
Plasmonic photothermal therapy (PPTT) using plasmonic nanoparticles as efficient photoabsorbing agents has been proposed previously. One critical step in PPTT is to effectively deliver gold nanoparticles into ...
-
Article
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We demonstrate here a molecular link between epithelial-to-mese...
-
Article
CSN6 drives carcinogenesis by positively regulating Myc stability
Cullin-RING ubiquitin ligases (CRLs) are critical in ubiquitinating Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL. The mechanistic link between Cullin neddylation and Myc ubiquitinati...
-
Article
Open AccessDissecting the Human Protein-Protein Interaction Network via Phylogenetic Decomposition
The protein-protein interaction (PPI) network offers a conceptual framework for better understanding the functional organization of the proteome. However, the intricacy of network complexity complicates compre...
-
Article
Open AccessAn open science resource for establishing reliability and reproducibility in functional connectomics
Efforts to identify meaningful functional imaging-based biomarkers are limited by the ability to reliably characterize inter-individual differences in human brain function. Although a growing number of connect...
-
Article
Open AccessLocal structure order in Pd78Cu6Si16 liquid
The short-range order (SRO) in Pd78Cu6Si16 liquid was studied by high energy x-ray diffraction and ab initio molecular dynamics (MD) simulations. The calculated pair correlation functions at different temperature...
-
Article
Open AccessFunctional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9)
The fatality of avian influenza A(H7N9) infection in humans was over 30%. To identify human genetic susceptibility to A(H7N9) infection, we performed a genome-wide association study (GWAS) involving 102 A(H7N9...
-
Article
Open AccessOutlier-resilient complexity analysis of heartbeat dynamics
Complexity in physiological outputs is believed to be a hallmark of healthy physiological control. How to accurately quantify the degree of complexity in physiological signals with outliers remains a major bar...
-
Article
Open AccessA New Approach to Reduce Toxicities and to Improve Bioavailabilities of Platinum-Containing Anti-Cancer Nanodrugs
Platinum (Pt) drugs are the most potent and commonly used anti-cancer chemotherapeutics. Nanoformulation of Pt drugs has the potential to improve the delivery to tumors and reduce toxic side effects. A major c...
